Arsenic Induces Insulin Resistance in Mouse Adipocytes and Myotubes Via Oxidative Stress-Regulated Mitochondrial Sirt3-FOXO3a Signaling Pathway

Acute and long-term effects of arsenite in HepG2 cells: modulation of insulin signaling

(2014) Ingrit Hamann et al.   BIOMETALS

Nrf2/p62 Signaling in Apoptosis Resistance and Its Role in Cadmium-induced Carcinogenesis

(2014) Young-Ok Son et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arsenic and type 2 diabetes: commentary on association of inorganic arsenic exposure with type 2 diabetes mellitus: a meta-analysis by Wanget al.

(2014) Alan Becker et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

(2013) E. Jing et al.   DIABETES

Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients

(2013) P. W. Caton et al.   DIABETOLOGIA

Prolonged environmental exposure of arsenic through drinking water on the risk of hypertension and type 2 diabetes

(2013) Xin Li et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus

(2013) Kristen E. Boyle et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Evaluation of the Association between Arsenic and Diabetes: A National Toxicology Program Workshop Review

(2012) Elizabeth A. Maull et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets

(2012) Christelle Douillet et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: Involvement of the adaptive antioxidant response

(2011) Peng Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of the Impaired Glucose Homeostasis Produced in C57BL/6 Mice by Chronic Exposure to Arsenic and High-Fat Diet

(2011) David S. Paul et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Arsenic-induced oxidative stress and its reversibility

(2011) Swaran J.S. Flora   FREE RADICAL BIOLOGY AND MEDICINE

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in metal-induced oxidative stress and human disease

(2011) Klaudia Jomova et al.   TOXICOLOGY

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Arsenic Inhibits Myogenic Differentiation and Muscle Regeneration

(2010) Yuan-Peng Yen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Low-Level Arsenic Impairs Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells: Involvement of Cellular Adaptive Response to Oxidative Stress

(2010) Jingqi Fu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice

(2009) Takashi Yokota et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Mutual Dependence of Foxo3a and PGC-1α in the Induction of Oxidative Stress Genes

(2009) Yolanda Olmos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

(2009) Nagalingam R. Sundaresan et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages

(2009) Courtney G. Woods et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Endurance Exercise as a Countermeasure for Aging

(2008) I. R. Lanza et al.   DIABETES

Arsenic Exposure and Prevalence of Type 2 Diabetes in US Adults

(2008) Ana Navas-Acien   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA