SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin

Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A

(2014) Yingying Lu et al.   Autophagy

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans

(2014) Roxane Paulin et al.   Cell Metabolism

Concentrations of selected heavy metals in maternal blood and associated factors in rural areas in Shanxi Province, China

(2014) Lei Jin et al.   ENVIRONMENT INTERNATIONAL

Sequential Actions of SIRT1-RELB-SIRT3 Coordinate Nuclear-Mitochondrial Communication during Immunometabolic Adaptation to Acute Inflammation and Sepsis

(2014) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin improves mitochondrial function in inguinal white adipose tissue of Zücker diabetic fatty rats

(2014) Aroa Jimenéz-Aranda et al.   JOURNAL OF PINEAL RESEARCH

Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin

(2014) Jenelle Govender et al.   JOURNAL OF PINEAL RESEARCH

A review of metal-catalyzed molecular damage: protection by melatonin

(2014) Alejandro Romero et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model

(2014) Lingling Zeng et al.   PLoS One

China Gets Serious About Its Pollutant-Laden Soil

(2014) C. Larson   SCIENCE

Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro

(2014) Pan Guo et al.   TOXICOLOGICAL SCIENCES

Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria

(2014) Kyriakos N. Papanicolaou et al.   Frontiers in Physiology

Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis

(2013) Randa Tao et al.   ANTIOXIDANTS & REDOX SIGNALING

The emerging role of acetylation in the regulation of autophagy

(2013) Ágnes Bánréti et al.   Autophagy

Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin

(2013) Yue-Mei Feng et al.   Autophagy

Dynamin 1-like-dependent mitochondrial fission initiates overactive mitophagy in the hepatotoxicity of cadmium

(2013) Huifeng Pi et al.   Autophagy

BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production

(2013) Yunha Kim et al.   Autophagy

Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts

(2013) Qiuli Liang et al.   BIOCHEMICAL JOURNAL

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels

(2013) Alessia Peserico et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Preserved endothelial function in human obesity in the absence of insulin resistance

(2013) Mariam El Assar et al.   Journal of Translational Medicine

Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity

(2013) S Xu et al.   Cell Death & Disease

Melatonin and Synthetic Analogs as Antioxidants

(2013) Sibel Suzen   Current Drug Delivery

Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species

(2012) Noemi Rubio et al.   Autophagy

Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis

(2012) Tiejun Zhang et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

Melatonin-mitochondria Interplay in Health and Disease

(2012) Dario Acuna Castroviejo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

(2012) Ubaldina Galli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SIRT3 regulation of mitochondrial oxidative stress

(2012) Alexandra S. Bause et al.   EXPERIMENTAL GERONTOLOGY

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity

(2012) Yueming Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress mediates chemerin-induced autophagy in endothelial cells

(2012) Weili Shen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

(2012) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

Mitochondrial oxidative stress mediates induction of autophagy and hypertrophy in angiotensin-II treated mouse hearts

(2011) Dao-Fu Dai et al.   Autophagy

Involvement of vascular peroxidase 1 in angiotensin II-induced vascular smooth muscle cell proliferation

(2011) Ruizheng Shi et al.   CARDIOVASCULAR RESEARCH

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells

(2011) Tetsuro Koyama et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes

(2011) Yan-Li Ji et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation

(2011) Chia-Fu Chang et al.   JOURNAL OF PINEAL RESEARCH

Nickel exposure induces oxidative damage to mitochondrial DNA in Neuro2a cells: the neuroprotective roles of melatonin

(2011) Shang-Cheng Xu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects against rotenone-induced cell injury via inhibition of Omi and Bax-mediated autophagy in Hela cells

(2011) Hongyan Zhou et al.   JOURNAL OF PINEAL RESEARCH

Oxidative Stress Stimulates Autophagic Flux During Ischemia/Reperfusion

(2010) Nirmala Hariharan et al.   ANTIOXIDANTS & REDOX SIGNALING

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

(2010) Agnieszka A. Kendrick et al.   BIOCHEMICAL JOURNAL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro

(2010) Junjiu Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity

(2010) Jianjun Bao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Oxidative Stress and Autophagy in Cardiac Disease, Neurological Disorders, Aging and Cancer

(2010) Eric E. Essick et al.   Oxidative Medicine and Cellular Longevity

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Melatonin administration ameliorates cadmium-induced oxidative stress and morphological changes in the liver of rat

(2009) Gamal H. El-Sokkary et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Effects of Selenium with Vitamin E and Melatonin on Cadmium-Induced Oxidative Damage in Rat Liver and Kidneys

(2008) Haki Kara et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Conserved Metabolic Regulatory Functions of Sirtuins

(2008) Bjoern Schwer et al.   Cell Metabolism

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA