Living with the enemy: from protein-misfolding pathologies we know, to those we want to know

Copper(II) and Amylin Analogues: A Complicated Relationship

(2020) Mawadda Alghrably et al.   INORGANIC CHEMISTRY

Alpha 1-Antitrypsin Deficiency: A Disorder of Proteostasis-Mediated Protein Folding and Trafficking Pathways

(2020) Esra Karatas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons

(2020) Rachel M. Furlong et al.   NEUROSCIENCE LETTERS

CSF SerpinA1 in Creutzfeldt–Jakob disease and frontotemporal lobar degeneration

(2020) Samir Abu‐Rumeileh et al.   Annals of Clinical and Translational Neurology

Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates

(2020) Hyungsun Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function

(2020) Ciaran P. A. Doherty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetics of Parkinson's disease: An introspection of its journey towards precision medicine

(2020) Sara Bandres-Ciga et al.   NEUROBIOLOGY OF DISEASE

Assessing the role of osmolytes on the conformational harmony of islet amyloid polypeptide

(2020) Anchala Kumari et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction

(2020) Júlia Rodríguez-Comas et al.   Molecular Metabolism

Glia-Derived Extracellular Vesicles in Parkinson’s Disease

(2020) Bianca Marchetti et al.   Journal of Clinical Medicine

Peripheral insulin and amylin levels in Parkinson's disease

(2020) Almudena Sánchez-Gómez et al.   PARKINSONISM & RELATED DISORDERS

Beyond thelungs: Alpha-1 antitrypsin’s potential role in human gestation

(2019) Aleksandra Jezela-Stanek et al.   Advances in Clinical and Experimental Medicine

Plasma Replacement Therapy for Alzheimer’s Disease

(2019) Xu-long Ding et al.   Neuroscience Bulletin

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases

(2019) Jiaming Zhang et al.   Frontiers in Neuroscience

4-PBA prevents diabetic muscle atrophy in rats by modulating ER stress response and ubiquitin-proteasome system

(2019) S. Sreenivasa Reddy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Alpha-1 Antitrypsin Deficiency and Accelerated Aging: A New Model for an Old Disease?

(2019) Diana Crossley et al.   DRUGS & AGING

α-Synuclein in Parkinson’s disease: causal or bystander?

(2019) Peter Riederer et al.   JOURNAL OF NEURAL TRANSMISSION

Diabetes drugs in the fight against Alzheimer's disease

(2019) Virginia Boccardi et al.   AGEING RESEARCH REVIEWS

The Preventive Effect of Liraglutide on the Lipotoxic Liver Injury via Increasing Autophagy

(2019) Yini He et al.   Annals of Hepatology

Towards the functional high-resolution coordination chemistry of blood plasma human serum albumin

(2019) Samah Al-Harthi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The genetic architecture of Parkinson's disease

(2019) Cornelis Blauwendraat et al.   LANCET NEUROLOGY

Autophagy induction in the treatment of Alzheimer's disease

(2019) Eran Schmukler et al.   DRUG DEVELOPMENT RESEARCH

Parkinson disease

(2019) R. Balestrino et al.   EUROPEAN JOURNAL OF NEUROLOGY

Pioglitazone protects tubular cells against hypoxia/reoxygenation injury through enhancing autophagy via AMPK-mTOR signaling pathway

(2019) Xiaoqing Xi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases

(2019) Alvin Djajadikerta et al.   JOURNAL OF MOLECULAR BIOLOGY

Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies

(2018) Ivan Martinez-Valbuena et al.   ACTA NEUROPATHOLOGICA

Systematic review: the natural history of alpha-1 antitrypsin deficiency, and associated liver disease

(2018) S. A. Townsend et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Implication of altered ubiquitin-proteasome system and ER stress in the muscle atrophy of diabetic rats

(2018) S. Sreenivasa Reddy et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

α 1 -Antitrypsin Polymerizes in Alveolar Macrophages of Smokers With and Without α 1 -Antitrypsin Deficiency

(2018) Erica Bazzan et al.   CHEST

A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects

(2018) Ellen Kraig et al.   EXPERIMENTAL GERONTOLOGY

Structural Modulation of Human Amylin Protofilaments by Naturally Occurring Mutations

(2018) Florentina Tofoleanu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Inhibition of Human Amylin Aggregation and Cellular Toxicity by Lipoic Acid and Ascorbic Acid

(2018) Sarah Kassem Azzam et al.   MOLECULAR PHARMACEUTICS

Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease

(2018) Emily M. Rocha et al.   NEUROBIOLOGY OF DISEASE

Association between diabetes and subsequent Parkinson disease

(2018) Eduardo De Pablo-Fernandez et al.   NEUROLOGY

Alpha-1 antitrypsin deficiency: outstanding questions and future directions

(2018) María Torres-Durán et al.   Orphanet Journal of Rare Diseases

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

(2018) Shigeto Sato et al.   Scientific Reports

Effect of 4-Phenylbutyric Acid and Tauroursodeoxycholic Acid on Magnesium and Calcium Metabolism in Streptozocin-Induced Type 1 Diabetic Mice

(2018) Qi Zhou et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Global trends in diabetes complications: a review of current evidence

(2018) Jessica L. Harding et al.   DIABETOLOGIA

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Perturbed Iron Distribution in Alzheimer's Disease Serum, Cerebrospinal Fluid, and Selected Brain Regions: A Systematic Review and Meta-Analysis

(2018) Yunlong Tao et al.   JOURNAL OF ALZHEIMERS DISEASE

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sitagliptin Protects Cardiac Function by Reducing Nitroxidative Stress and Promoting Autophagy in Zucker Diabetic Fatty (ZDF) Rats

(2018) Yi Zhou et al.   CARDIOVASCULAR DRUGS AND THERAPY

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Mitochondrial dynamics, a key executioner in neurodegenerative diseases

(2018) Komal Panchal et al.   MITOCHONDRION

The hidden side of Parkinson’s disease: Studying pain, anxiety and depression in animal models

(2018) Fanny Faivre et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

(2018) Manuel Janeiro et al.   Nutrients

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

(2018) Nicholas M. Vogt et al.   Alzheimers Research & Therapy

The Emerging Evidence of the Parkinson Pandemic

(2018) E. Ray Dorsey et al.   Journal of Parkinsons Disease

Interaction of amylin species with transition metals and membranes

(2018) Mawadda Alghrably et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Efficacy and Safety of Plasma Exchange with 5% Albumin to Modify Cerebrospinal Fluid and Plasma Amyloid-β Concentrations and Cognition Outcomes in Alzheimer’s Disease Patients: A Multicenter, Randomized, Controlled Clinical Trial

(2017) Mercè Boada et al.   JOURNAL OF ALZHEIMERS DISEASE

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins

(2017) Prashant Bharadwaj et al.   JOURNAL OF ALZHEIMERS DISEASE

Inherited disorders of transition metal metabolism: an update

(2017) Peter T. Clayton   JOURNAL OF INHERITED METABOLIC DISEASE

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Alzheimer’s Disease: Past, Present, and Future

(2017) Mark W. Bondi et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Valery L Feigin et al.   LANCET NEUROLOGY

Alpha-1-antitrypsin deficiency: Genetic variations, clinical manifestations and therapeutic interventions

(2017) Younis Mohammad Hazari et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer’s Disease

(2017) Yong Li et al.   Frontiers in Molecular Neuroscience

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management

(2017) Arun Chaudhury et al.   Frontiers in Endocrinology

Characterization of plasma metal profiles in Alzheimer’s disease using multivariate statistical analysis

(2017) Chunmei Guan et al.   PLoS One

The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets

(2016) Daniel T. Meier et al.   DIABETOLOGIA

Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I

(2016) Wendy A. Davis et al.   DIABETOLOGIA

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

(2016) M. Dambrova et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Derangement of calcium metabolism in diabetes mellitus: negative outcome from the synergy between impaired bone turnover and intestinal calcium absorption

(2016) Kannikar Wongdee et al.   Journal of Physiological Sciences

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies

(2016) Maria Xilouri et al.   MOVEMENT DISORDERS

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson’s disease

(2016) Istvan Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Dose-Response Relationship between Dietary Magnesium Intake and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Regression Analysis of Prospective Cohort Studies

(2016) Xin Fang et al.   Nutrients

Modified serpinA1 as risk marker for Parkinson’s disease dementia: Analysis of baseline data

(2016) Steffen Halbgebauer et al.   Scientific Reports

The secret life of extracellular vesicles in metal homeostasis and neurodegeneration

(2015) Shayne A. Bellingham et al.   BIOLOGY OF THE CELL

Post-translational modification of α-synuclein in Parkinson׳s disease

(2015) Paul J. Barrett et al.   BRAIN RESEARCH

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

(2015) Ana Paula Arruda et al.   Cell Metabolism

European screening for alpha1-antitrypsin deficiency in subjects with lung disease

(2015) Timm Greulich et al.   Clinical Respiratory Journal

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity

(2015) Adriana Ordóñez et al.   FASEB JOURNAL

Autophagy and neurodegeneration

(2015) Rebecca A. Frake et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin and other antidiabetic agents in renal failure patients

(2015) Jean-Daniel Lalau et al.   KIDNEY INTERNATIONAL

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

(2015) Ulf Dettmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Le déficit en alpha-1 antitrypsine : modèle d’altération de l’homéostasie protéique ou protéostasie

(2015) H. Vignaud et al.   REVUE DES MALADIES RESPIRATOIRES

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention

(2014) Yanling Wu et al.   International Journal of Medical Sciences

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

(2014) Jacqueline F. Rivera et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation

(2014) B I Pérez-Revuelta et al.   Cell Death & Disease

Amylin deposition in the brain: A second amyloid in Alzheimer disease?

(2013) Kaleena Jackson et al.   ANNALS OF NEUROLOGY

pH Dependence of Amylin Fibrillization

(2013) Suman Jha et al.   BIOCHEMISTRY

Twenty Years of Polymers: A Personal Perspective on Alpha-1 Antitrypsin Deficiency

(2013) David A. Lomas   COPD-Journal of Chronic Obstructive Pulmonary Disease

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

The levels of copper, zinc and magnesium in type II diabetic patients complicated with foot infections

(2013) Fatma Bozkurt et al.   International Journal of Diabetes in Developing Countries

Disorders of Protein Misfolding: Alpha-1-Antitrypsin Deficiency as Prototype

(2013) Gary A. Silverman et al.   JOURNAL OF PEDIATRICS

pH Effects on the Molecular Structure of β-Lactoglobulin Modified Air–Water Interfaces and Its Impact on Foam Rheology

(2013) Kathrin Engelhardt et al.   LANGMUIR

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

Deficiency of α-1-antitrypsin influences systemic iron homeostasis

(2013) Andrew Ghio et al.   International Journal of Chronic Obstructive Pulmonary Disease

Tau Oligomers as Potential Targets for Alzheimer’s Diagnosis and Novel Drugs

(2013) Leonardo Guzmán-Martinez et al.   Frontiers in Neurology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Cellular Responses to the Metal-Binding Properties of Metformin

(2012) L. Logie et al.   DIABETES

Degradation of islet amyloid polypeptide by neprilysin

(2012) H. Guan et al.   DIABETOLOGIA

Histone Deacetylase Inhibitor (HDACi) Suberoylanilide Hydroxamic Acid (SAHA)-mediated Correction of α1-Antitrypsin Deficiency

(2012) Marion Bouchecareilh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann-Straussler-Scheinker Disease

(2012) C. J. Cortes et al.   JOURNAL OF NEUROSCIENCE

Recent Advances in α-Synuclein Functions, Advanced Glycation, and Toxicity: Implications for Parkinson’s Disease

(2012) Erika Guerrero et al.   MOLECULAR NEUROBIOLOGY

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Therapeutic Effects of Rapamycin on MPTP-Induced Parkinsonism in Mice

(2012) Kangyong Liu et al.   NEUROCHEMICAL RESEARCH

Clinical features of Parkinson disease when onset of diabetes came first: A case-control study

(2012) E. Cereda et al.   NEUROLOGY

Differential Sialylation of Serpin A1 in the Early Diagnosis of Parkinson’s Disease Dementia

(2012) Sarah Jesse et al.   PLoS One

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

(2012) I.-F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein

(2012) Adam J. Trexler et al.   PROTEIN SCIENCE

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

A Review of α1-Antitrypsin Deficiency

(2011) James K. Stoller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

α-Synuclein misfolding and Parkinson's disease

(2011) Leonid Breydo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A mechanistic approach for islet amyloid polypeptide aggregation to develop anti-amyloidogenic agents for type-2 diabetes

(2011) Ejaz Ahmad et al.   BIOCHIMIE

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage

(2011) SH Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metal-based anti-diabetic drugs: advances and challenges

(2011) Aviva Levina et al.   DALTON TRANSACTIONS

Therapeutic Potential of Copper Chelation with Triethylenetetramine in Managing Diabetes Mellitus and Alzheimerʼs Disease

(2011) Garth J.S. Cooper   DRUGS

Endoplasmic Reticulum Stress and Diabetic Cardiomyopathy

(2011) Jiancheng Xu et al.   Experimental Diabetes Research

Clustering and Internalization of Toxic Amylin Oligomers in Pancreatic Cells Require Plasma Membrane Cholesterol

(2011) Saurabh Trikha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue 20

(2011) Ping Cao et al.   JOURNAL OF MOLECULAR BIOLOGY

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein

(2011) Nathalie Sibille et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms

(2011) T Tomic et al.   Cell Death & Disease

Chelation in Metal Intoxication

(2011) Swaran J.S. Flora et al.   International Journal of Environmental Research and Public Health

2010 Alzheimer's disease facts and figures

(2010)   Alzheimers & Dementia

Alpha-1-Antitrypsin Deficiency: Importance of Proteasomal and Autophagic Degradative Pathways in Disposal of Liver Disease–Associated Protein Aggregates

(2010) David H. Perlmutter   Annual Review of Medicine

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

(2010) J F Rivera et al.   CELL DEATH AND DIFFERENTIATION

 -Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 Deficiency

(2010) S. Costes et al.   DIABETES

The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes

(2010) Lucie Khemtémourian et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

(2010) Ana Ricobaraza et al.   HIPPOCAMPUS

Neprilysin Impedes Islet Amyloid Formation by Inhibition of Fibril Formation Rather Than Peptide Degradation

(2010) Sakeneh Zraika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of alpha-synuclein in neurotransmission and synaptic plasticity

(2010) Furong Cheng et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

HFE mutations in α-1-antitrypsin deficiency: an examination of cirrhotic explants

(2010) Maggie Lam et al.   MODERN PATHOLOGY

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

(2010) A. S. Tsvetkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the mechanism of polymerization in the serpinopathies

(2010) U. I. Ekeowa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: Regulation of endoplasmic reticulum stress-oxidative activation

(2010) Zhi-Feng Luo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Conformational Pathology of the Serpins: Themes, Variations, and Therapeutic Strategies

(2009) Bibek Gooptu et al.   Annual Review of Biochemistry

Methylene blue and Alzheimer's disease

(2009) Murat Oz et al.   BIOCHEMICAL PHARMACOLOGY

Two Disaccharides and TrimethylamineN-Oxide Affect Aβ Aggregation Differently, but All Attenuate Oligomer-Induced Membrane Permeability

(2009) Wei Qi et al.   BIOCHEMISTRY

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

Diabetes- and angiotensin II-induced cardiac endoplasmic reticulum stress and cell death: metallothionein protection

(2009) Jiancheng Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cholesterol Regulates Assembly of Human Islet Amyloid Polypeptide on Model Membranes

(2009) Won-Jin Cho et al.   JOURNAL OF MOLECULAR BIOLOGY

Chelation therapy for neurodegenerative diseases

(2009) Silvia Bolognin et al.   MEDICINAL RESEARCH REVIEWS

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human α-synuclein A30P+A53T transgenic mice

(2009) Kazuhiko Ono et al.   PARKINSONISM & RELATED DISORDERS

Two-dimensional IR spectroscopy and isotope labeling defines the pathway of amyloid formation with residue-specific resolution

(2009) S.-H. Shim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2008 Alzheimer’s disease facts and figures

(2008)   Alzheimers & Dementia

Synthesis, Characterization and Hypoglycemic Activity of Zn(II), Cd(II) and Hg(II) Complexes with Glibenclamide

(2008) Khalid Rasheed et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

The Role of Zinc, Copper and Iron in the Pathogenesis of Diabetes and Diabetic Complications: Therapeutic Effects by Chelators

(2008) Yang Zheng et al.   HEMOGLOBIN

Polymers and inflammation: disease mechanisms of the serpinopathies

(2008) Bibek Gooptu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

(2008) Raj N Kalaria et al.   LANCET NEUROLOGY

Small molecule enhancers of autophagy for neurodegenerative diseases

(2008) Sovan Sarkar et al.   Molecular BioSystems

Hereditary alpha-1-antitrypsin deficiency and its clinical consequences

(2008) Laura Fregonese et al.   Orphanet Journal of Rare Diseases

Islet Amyloid Polypeptide Forms Rigid Lipid–Protein Amyloid Fibrils on Supported Phospholipid Bilayers

(2007) Yegor A. Domanov et al.   JOURNAL OF MOLECULAR BIOLOGY