Conformational Pathology of the Serpins: Themes, Variations, and Therapeutic Strategies

Cleaved antitrypsin polymers at atomic resolution

(2010) Michelle A. Dunstone et al.   PROTEIN SCIENCE

Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins

(2010) Wun-Shaing W. Chang et al.   PROTEIN SCIENCE

Serpins show structural basis for oligomer toxicity and amyloid ubiquity

(2008) Robin W. Carrell et al.   FEBS LETTERS

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB

(2008) E. Miranda et al.   HUMAN MOLECULAR GENETICS

The molecular aetiology of the serpinopathies

(2008) M DAVIES et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Polymers and inflammation: disease mechanisms of the serpinopathies

(2008) Bibek Gooptu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Structural Basis for Loop C-Sheet Polymerization in Serpins

(2008) Qingwei Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

The S-to-R Transition of Corticosteroid-Binding Globulin and the Mechanism of Hormone Release

(2008) Aiwu Zhou et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

(2008) Masayuki Yamasaki et al.   NATURE

NEUROSERPIN MUTATION CAUSES ELECTRICAL STATUS EPILEPTICUS OF SLOW-WAVE SLEEP

(2008) M. Coutelier et al.   NEUROLOGY

Dimers Initiate and Propagate Serine Protease Inhibitor Polymerisation

(2007) Aiwu Zhou et al.   JOURNAL OF MOLECULAR BIOLOGY

Cavities of α1-antitrypsin that play structural and functional roles

(2002) Cheolju Lee et al.   PROTEIN SCIENCE