Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer’s Disease

Treponema, Iron and Neurodegeneration

(2018) A. Jolivet-Gougeon et al.   Current Alzheimer Research

Role of copper in human neurological disorders

(2018) Vishal Desai et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Copper in Alzheimer's Disease: A Meta-Analysis of Serum, Plasma, and Cerebrospinal Fluid Studies

(2018) Mariacarla Ventriglia et al.   JOURNAL OF ALZHEIMERS DISEASE

Intronic rs2147363 Variant in ATP7B Transcription Factor-Binding Site Associated with Alzheimer's Disease

(2018) Serena Bucossi et al.   JOURNAL OF ALZHEIMERS DISEASE

High Manganese, A Risk for Alzheimer's Disease: High Manganese Induces Amyloid-β Related Cognitive Impairment

(2018) Yawei Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

Perturbed Iron Distribution in Alzheimer's Disease Serum, Cerebrospinal Fluid, and Selected Brain Regions: A Systematic Review and Meta-Analysis

(2018) Yunlong Tao et al.   JOURNAL OF ALZHEIMERS DISEASE

The zinc paradigm for metalloneurochemistry

(2017) Chelsea A. Barr et al.   Essays in Biochemistry

Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A

(2017) Corey H. Yu et al.   IUBMB LIFE

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

(2017) Xiaoyan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity

(2017) Wen Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Metal Transporter Zip14 ( Slc39a14 ) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity

(2017) Tolunay Beker Aydemir et al.   JOURNAL OF NEUROSCIENCE

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

(2017) Michal Arbel-Ornath et al.   Molecular Neurodegeneration

Ca2+-permeable AMPA receptor: A new perspective on amyloid-beta mediated pathophysiology of Alzheimer's disease

(2017) Garry Whitehead et al.   NEUROPHARMACOLOGY

Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10 , a Manganese Transporter in Man

(2016) Karin Tuschl et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A possible significant role of zinc and GPR39 zinc sensing receptor in Alzheimer disease and epilepsy

(2016) Muhammad Zahid Khan   BIOMEDICINE & PHARMACOTHERAPY

Brain biometals and Alzheimer's disease – boon or bane?

(2016) Atish Prakash et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Patterns of Brain Iron Accumulation in Vascular Dementia and Alzheimer’s Dementia Using Quantitative Susceptibility Mapping Imaging

(2016) Yeonsil Moon et al.   JOURNAL OF ALZHEIMERS DISEASE

Ten Challenges of the Amyloid Hypothesis of Alzheimer’s Disease

(2016) Kasper Planeta Kepp   JOURNAL OF ALZHEIMERS DISEASE

A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity

(2016) Jack T. Rogers et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer⿿s disease

(2016) Cecilia Wallin et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Brain Iron Metabolism Dysfunction in Parkinson’s Disease

(2016) Hong Jiang et al.   MOLECULAR NEUROBIOLOGY

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

(2016) P Lei et al.   MOLECULAR PSYCHIATRY

Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity

(2016) Ziyan Zhang et al.   NEUROCHEMICAL RESEARCH

Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats

(2015) Madhavan Nampoothiri et al.   BEHAVIOURAL NEUROLOGY

TRPM7 and its role in neurodegenerative diseases

(2015) Yuyang Sun et al.   Channels

A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease

(2015) Fanfei Meng et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Ferroportin deficiency impairs manganese metabolism in flatiron mice

(2015) Young Ah Seo et al.   FASEB JOURNAL

The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to  -Amyloid Oligomer-Related Neurotoxicity and Memory Impairment

(2015) V. G. Ostapchenko et al.   JOURNAL OF NEUROSCIENCE

Age-related changes of brain iron load changes in the frontal cortex in APPswe/PS1ΔE9 transgenic mouse model of Alzheimer's disease

(2015) Dong Xian-hui et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Multi-target iron-chelators improve memory loss in a rat model of sporadic Alzheimer's disease

(2015) Melita Salkovic-Petrisic et al.   LIFE SCIENCES

Iron and Neurodegeneration: Is Ferritinophagy the Link?

(2015) Giorgio Biasiotto et al.   MOLECULAR NEUROBIOLOGY

Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload

(2015) Xi-qing Chai et al.   Neural Regeneration Research

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

(2015) Peng Lei et al.   NEUROBIOLOGY OF DISEASE

Magnesium in Man: Implications for Health and Disease

(2015) Jeroen H. F. de Baaij et al.   PHYSIOLOGICAL REVIEWS

Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells

(2015) Miguel Chin-Chan et al.   TOXICOLOGICAL SCIENCES

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

(2015) Miguel Chin-Chan et al.   Frontiers in Cellular Neuroscience

Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss

(2015) J H Birnbaum et al.   Cell Death & Disease

Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization

(2015) Sook-Jeong Lee et al.   Molecular Brain

Neurotherapeutic effects of novel HO-1 inhibitorsin vitroand in a transgenic mouse model of Alzheimer's disease

(2015) Ajay Gupta et al.   JOURNAL OF NEUROCHEMISTRY

Age-related iron deposition in the basal ganglia of controls and Alzheimer disease patients quantified using susceptibility weighted imaging

(2014) Dan Wang et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Protection of SK-N-MC cells against β-amyloid peptide-induced degeneration using neuron growth factor-loaded liposomes with surface lactoferrin

(2014) Yung-Chih Kuo et al.   BIOMATERIALS

Heavy metals toxicity: effect of cadmium ions on amyloid beta protein 1–42. Possible implications for Alzheimer’s disease

(2014) Gabriella Notarachille et al.   BIOMETALS

Alzheimer’s Disease Biomarkers and Epigenetic Intermediates Following Exposure to Pb In Vitro

(2014) Syed Waseem Bihaqi et al.   Current Alzheimer Research

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

(2014) R. C. McCarthy et al.   EMBO REPORTS

Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells

(2014) Karla M. Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is the Aluminum Hypothesis Dead?

(2014) Theodore I. Lidsky   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Mercury-induced amyloid-beta (Aβ) accumulation in the brain is mediated by disruption of Aβ transport

(2014) Dong-Kyeong Kim et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment

(2014) David R. Whitfield et al.   NEUROBIOLOGY OF AGING

Biometals and Their Therapeutic Implications in Alzheimer’s Disease

(2014) Scott Ayton et al.   Neurotherapeutics

Magnesium Protects Cognitive Functions and Synaptic Plasticity in Streptozotocin-Induced Sporadic Alzheimer’s Model

(2014) Zhi-Peng Xu et al.   PLoS One

Clioquinol promotes the degradation of metal-dependent amyloid-  (A ) oligomers to restore endocytosis and ameliorate A  toxicity

(2014) K. E. S. Matlack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Higher sensitivity to cadmium induced cell death of basal forebrain cholinergic neurons: A cholinesterase dependent mechanism

(2014) Javier Del Pino et al.   TOXICOLOGY

Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model

(2014) Wei Li et al.   Molecular Brain

Serum Trace Metal Levels in Alzheimer’s Disease and Normal Control Groups

(2013) Jun-Hyun Park et al.   American Journal of Alzheimers Disease and Other Dementias

Manganese neurotoxicity and the role of reactive oxygen species

(2013) Ebany J. Martinez-Finley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Survival in dementia and predictors of mortality: a review

(2013) Stephen Todd et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

The SLC30 family of zinc transporters – A review of current understanding of their biological and pathophysiological roles

(2013) Liping Huang et al.   MOLECULAR ASPECTS OF MEDICINE

Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease–like symptoms

(2013) Minglin Lang et al.   NEUROBIOLOGY OF AGING

Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors

(2013) Sandra I. Mota et al.   NEUROPHARMACOLOGY

Potential roles of zinc in the pathophysiology and treatment of major depressive disorder

(2013) Walter Swardfager et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cadmium and Its Neurotoxic Effects

(2013) Bo Wang et al.   Oxidative Medicine and Cellular Longevity

Cadmium-Induced Apoptosis in Primary Rat Cerebral Cortical Neurons Culture Is Mediated by a Calcium Signaling Pathway

(2013) Yan Yuan et al.   PLoS One

Altered Expression of ZnT10 in Alzheimer's Disease Brain

(2013) Helen J. Bosomworth et al.   PLoS One

Chronic manganese exposure impairs visuospatial associative learning in non-human primates

(2013) J.S. Schneider et al.   TOXICOLOGY LETTERS

Magnesium in Disease Prevention and Overall Health

(2013) Stella Lucia Volpe   Advances in Nutrition

Manganese neurotoxicity: new perspectives from behavioral, neuroimaging, and neuropathological studies in humans and non-human primates

(2013) Tomás R. Guilarte   Frontiers in Aging Neuroscience

Abnormal iron homeostasis and neurodegeneration

(2013) Barry B. Muhoberac et al.   Frontiers in Aging Neuroscience

ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies

(2013) Karen E Murphy et al.   Acta Neuropathologica Communications

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

(2013) Animesh Raha et al.   Acta Neuropathologica Communications

Proteomic Changes in Cerebrospinal Fluid of Presymptomatic and Affected Persons Carrying Familial Alzheimer Disease Mutations

(2012) John M. Ringman   ARCHIVES OF NEUROLOGY

The Human ZIP4 Transporter Has Two Distinct Binding Affinities and Mediates Transport of Multiple Transition Metals

(2012) Sagar Antala et al.   BIOCHEMISTRY

Rapid Exchange of Metal between Zn7–Metallothionein-3 and Amyloid-β Peptide Promotes Amyloid-Related Structural Changes

(2012) Jeppe T. Pedersen et al.   BIOCHEMISTRY

The role of iron as a mediator of oxidative stress in Alzheimer disease

(2012) Rudy J. Castellani et al.   BIOFACTORS

Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer’s disease

(2012) Yasmina Manso et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of the role of metallothionein-3 in an animal model of Alzheimer’s disease

(2012) Yasmina Manso et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration

(2012) Natalia VanDuyn et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid neurotoxicity is attenuated by metallothionein: dual mechanisms at work

(2012) Jong-Heon Kim et al.   JOURNAL OF NEUROCHEMISTRY

Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells

(2012) Hitomi Fujishiro et al.   Metallomics

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Astrocyte functions in the copper homeostasis of the brain

(2012) Ivo F. Scheiber et al.   NEUROCHEMISTRY INTERNATIONAL

Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain

(2012) Chuang Guo et al.   NEUROCHEMISTRY INTERNATIONAL

Linkage Disequilibrium and Haplotype Analysis of the ATP7B Gene in Alzheimer's Disease

(2012) Rosanna Squitti et al.   REJUVENATION RESEARCH

The effect of cadmium on Aβ levels in APP/PS1 transgenic mice

(2012) XIAOLING LI et al.   Experimental and Therapeutic Medicine

Human gene SLC41A1 encodes for the Na+/Mg2+ exchanger

(2011) Martin Kolisek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cellular magnesium homeostasis

(2011) Andrea M.P. Romani   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The iron transporter ferroportin can also function as a manganese exporter

(2011) Michael S. Madejczyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Melanotransferrin: Search for a function

(2011) Yohan Suryo Rahmanto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Transition metal abnormalities in progressive dementias

(2011) Hiroyasu Akatsu et al.   BIOMETALS

Modulation of transient receptor potential melastatin related 7 channel by presenilins

(2011) Hyun Geun Oh et al.   Developmental Neurobiology

Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

(2011) Mark A. Greenough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Patterns of levels of biological metals in CSF differ among neurodegenerative diseases

(2011) Isao Hozumi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Copper inducing Aβ42 rather than Aβ40 nanoscale oligomer formation is the key process for Aβ neurotoxicity

(2011) Lu Jin et al.   Nanoscale

In vitro Pb exposure disturbs the balance between Aβ production and elimination: The role of AβPP and neprilysin

(2011) Hui Huang et al.   NEUROTOXICOLOGY

Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases

(2011) Wei Zheng et al.   PHARMACOLOGY & THERAPEUTICS

Mg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels

(2010) Moonhee Lee et al.   BRAIN RESEARCH

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Copper Promotes the Trafficking of the Amyloid Precursor Protein

(2010) Karla M. Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

(2010) Beinan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme oxygenase-1 in Alzheimer disease: a tribute to Moussa Youdim

(2010) Hyman M. Schipper   JOURNAL OF NEURAL TRANSMISSION

Altered microglial copper homeostasis in a mouse model of Alzheimer’s disease

(2010) Zhiqiang Zheng et al.   JOURNAL OF NEUROCHEMISTRY

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

(2010) P. A. Adlard et al.   JOURNAL OF NEUROSCIENCE

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production

(2010) Zhihao Wu et al.   NEUROBIOLOGY OF AGING

Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer's disease

(2010) Ligang Wang et al.   NEUROSCIENCE LETTERS

Lead exposure increases levels of β-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice

(2010) Huiying Gu et al.   NEUROSCIENCE LETTERS

APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

(2010) Tomás R. Guilarte   NEUROTOXICOLOGY

Copper Homeostasis: The Role of Cellular Transporters

(2010) Edward D. Harris   NUTRITION REVIEWS

Manganese Accumulates within Golgi Apparatus in Dopaminergic Cells as Revealed by Synchrotron X-ray Fluorescence Nanoimaging

(2009) Asunción Carmona et al.   ACS Chemical Neuroscience

Divalent metal transporter 1 is involved in amyloid precursor protein processing and Aβ generation

(2009) Wei Zheng et al.   FASEB JOURNAL

Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   FASEB JOURNAL

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

(2009) Masashi Kitazawa et al.   JOURNAL OF NEUROCHEMISTRY

Restored degradation of the Alzheimer’s amyloid-β peptide by targeting amyloid formation

(2009) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

A Role for Synaptic Zinc in Activity-Dependent A  Oligomer Formation and Accumulation at Excitatory Synapses

(2009) A. Deshpande et al.   JOURNAL OF NEUROSCIENCE

Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine

(2009) S. E. Kotermanski et al.   JOURNAL OF NEUROSCIENCE

Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer's disease

(2009) Li An et al.   NEUROSCIENCE LETTERS

Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain

(2009) Masatake Fujimura et al.   NEUROTOXICOLOGY

Copper deficiency alters the neurochemical profile of developing rat brain

(2009) Anna A. Gybina et al.   NUTRITIONAL NEUROSCIENCE

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule blockers of the Alzheimer A  calcium channel potently protect neurons from A  cytotoxicity

(2009) J. C. Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cognitive Dysfunction Associated with Elemental Mercury Ingestion and Inhalation: A Case Study

(2008) Steven P. Cercy et al.   APPLIED NEUROPSYCHOLOGY

Reverse mode Na + /Ca 2+ exchangers trigger the release of Ca 2+ from intracellular Ca 2+ stores in cultured rat embryonic cortical neurons

(2008) Meng-Pei Wu et al.   BRAIN RESEARCH

Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain

(2008) Li-Hong Zhang et al.   BRAIN RESEARCH BULLETIN

The risks of free copper in the body and the development of useful anticopper drugs

(2008) George J Brewer   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Metal Concentrations in Plasma and Cerebrospinal Fluid in Patients with Alzheimer’s Disease

(2008) Lars Gerhardsson et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD

(2008) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics

Amyloid beta peptides and glutamatergic synaptic dysregulation

(2007) Kodeeswaran Parameshwaran et al.   EXPERIMENTAL NEUROLOGY

Binding of zinc(II) and copper(II) to the full-length Alzheimer’s amyloid-β peptide

(2007) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer’s disease as copper deficiency

(2007) Leslie M. Klevay   MEDICAL HYPOTHESES