Macrophages in microgravity: the impact of space on immune cells

Spaceflight and simulated microgravity suppresses macrophage development via altered RAS/ERK/NFκB and metabolic pathways

(2020) Lu Shi et al.   Cellular & Molecular Immunology

Molecular regulation of TLR signaling in health and disease: mechano-regulation of macrophages and TLR signaling

(2020) Erika J Gruber et al.   Innate Immunity

Expression of Hypoxia-Inducible Factor 1α (HIF-1α) and Genes of Related Pathways in Altered Gravity

(2019) Johannes Vogel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1

(2019) Cecilia Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Validation of Random Positioning Versus Clinorotation Using a Macrophage Model System

(2019) Sonja Brungs et al.   MICROGRAVITY SCIENCE AND TECHNOLOGY

Rapid Morphological and Cytoskeletal Response to Microgravity in Human Primary Macrophages

(2019) Cora Sandra Thiel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage Polarization in Physiological and Pathological Pregnancy

(2019) Yongli Yao et al.   Frontiers in Immunology

Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions

(2018) Brian E. Crucian et al.   Frontiers in Immunology

Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells

(2018) Cora S. Thiel et al.   Scientific Reports

Harnessing Macrophages for Vascularization in Tissue Engineering

(2018) Erika M. Moore et al.   ANNALS OF BIOMEDICAL ENGINEERING

Cytoskeletal stability and metabolic alterations in primary human macrophages in long-term microgravity

(2017) Svantje Tauber et al.   PLoS One

Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy

(2017) Carlo Pergola et al.   Scientific Reports

Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity

(2017) Stephen D. Thorpe et al.   Nucleus

Human Pathophysiological Adaptations to the Space Environment

(2017) Gian C. Demontis et al.   Frontiers in Physiology

Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity

(2017) Stephen D. Thorpe et al.   Nucleus

Rapid adaptation to microgravity in mammalian macrophage cells

(2017) Cora S. Thiel et al.   Scientific Reports

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

The Effect of Simulated Microgravity on Differentiation of Porcine Blood-Derived Vascular Stem Cells

(2016) Vidhya Ramaswamy et al.   STEM CELLS AND DEVELOPMENT

Towards human exploration of space: The THESEUS review series on immunology research priorities

(2016) Jean-Pol Frippiat et al.   NPJ Microgravity

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Syk phosphorylation – a gravisensitive step in macrophage signalling

(2015) Sonja Brungs et al.   Cell Communication and Signaling

Simulated microgravity promotes monocyte adhesion to rat aortic endothelium via nuclear factor-κB activation

(2015) Huan Liu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Microgravity activates p38 MAPK-C/EBPβ pathway to regulate the expression of arginase and inflammatory cytokines in macrophages

(2015) Chongzhen Wang et al.   INFLAMMATION RESEARCH

Regulation of ICAM-1 in Cells of the Monocyte/Macrophage System in Microgravity

(2015) Katrin Paulsen et al.   Biomed Research International

Simulated Microgravity: Critical Review on the Use of Random Positioning Machines for Mammalian Cell Culture

(2015) Simon L. Wuest et al.   Biomed Research International

The Impact of Microgravity and Hypergravity on Endothelial Cells

(2015) Jeanette A. M. Maier et al.   Biomed Research International

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton

(2014) Pablo Rougerie et al.   IMMUNOLOGICAL REVIEWS

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

(2014) Guillermo Arango Duque et al.   Frontiers in Immunology

Severe disruption of the cytoskeleton and immunologically relevant surface molecules in a human macrophageal cell line in microgravity—Results of an in vitro experiment on board of the Shenzhou-8 space mission

(2013) Katrin Paulsen et al.   ACTA ASTRONAUTICA

The oxidative burst reaction in mammalian cells depends on gravity

(2013) Astrid Adrian et al.   Cell Communication and Signaling

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

(2013) Yan Zhang et al.   CELL RESEARCH

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Microgravity inhibition of lipopolysaccharide-induced tumor necrosis factor-α expression in macrophage cells

(2013) Chongzhen Wang et al.   INFLAMMATION RESEARCH

Beyond Stem Cells: Self-Renewal of Differentiated Macrophages

(2013) M. H. Sieweke et al.   SCIENCE

Getting Leukocytes to the Site of Inflammation

(2013) W. A. Muller   VETERINARY PATHOLOGY

Ground-Based Facilities for Simulation of Microgravity: Organism-Specific Recommendations for Their Use, and Recommended Terminology

(2012) Raul Herranz et al.   ASTROBIOLOGY

Hypoxia-mediated regulation of macrophage functions in pathophysiology

(2012) Elena Riboldi et al.   INTERNATIONAL IMMUNOLOGY

A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease

(2012) Branden Stansley et al.   Journal of Neuroinflammation

Monocyte Phenotype and Cytokine Production Profiles Are Dysregulated by Short-Duration Spaceflight

(2011) Brian Crucian et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Space flight affects motility and cytoskeletal structures in human monocyte cell line J-111

(2011) Maria Antonia Meloni et al.   Cytoskeleton

A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation

(2011) Luke C. Davies et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

To infinity … and beyond! Human spaceflight and life science

(2011) Millie Hughes-Fulford   FASEB JOURNAL

Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types

(2011) Elly JF Vereyken et al.   Journal of Neuroinflammation

Microgravity-induced alterations in signal transduction in cells of the immune system

(2010) Katrin Paulsen et al.   ACTA ASTRONAUTICA

The human cardiovascular system during space flight

(2010) A.I. Grigoriev et al.   ACTA ASTRONAUTICA

Bioastronautics: The Influence of Microgravity on Astronaut Health

(2010) Elizabeth Blaber et al.   ASTROBIOLOGY

WASH and the Arp2/3 complex regulate endosome shape and trafficking

(2010) Steve N. Duleh et al.   Cytoskeleton

Effects of spaceflight on innate immune function and antioxidant gene expression

(2009) Farnaz P. Baqai et al.   JOURNAL OF APPLIED PHYSIOLOGY

Technology and Developments for the Random Positioning Machine, RPM

(2009) A. G. Borst et al.   MICROGRAVITY SCIENCE AND TECHNOLOGY

The dynamics of parabolic flight: Flight characteristics and passenger percepts

(2008) Faisal Karmali et al.   ACTA ASTRONAUTICA

CD13 is a novel mediator of monocytic/endothelial cell adhesion

(2008) Paola Mina-Osorio et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophage activation by endogenous danger signals

(2007) X Zhang et al.   JOURNAL OF PATHOLOGY