Hypoxia-mediated regulation of macrophage functions in pathophysiology

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia Triggers the Expression of Human   Defensin 2 and Antimicrobial Activity against Mycobacterium tuberculosis in Human Macrophages

(2012) D. Nickel et al.   JOURNAL OF IMMUNOLOGY

The Prolyl Hydroxylase PHD3 Identifies Proinflammatory Macrophages and Its Expression Is Regulated by Activin A

(2012) M. M. Escribese et al.   JOURNAL OF IMMUNOLOGY

Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis

(2012) J. Kiss et al.   JOURNAL OF IMMUNOLOGY

Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

(2012) Sofia Konisti et al.   Nature Reviews Rheumatology

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

(2011) Roberta Mazzieri et al.   CANCER CELL

Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

(2011) M. Muthana et al.   CANCER RESEARCH

Early Macrophage Recruitment and Alternative Activation Are Critical for the Later Development of Hypoxia-Induced Pulmonary Hypertension

(2011) Eleni Vergadi et al.   CIRCULATION

Macrophages in cancer and infectious diseases: the ‘good’ and the ‘bad’

(2011) Chiara Porta et al.   Immunotherapy

TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

(2011) Abigail F. Welford et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulations of Glucocorticoid-Induced Leucine Zipper by Hypoxia and Glucocorticoid Inhibit Proinflammatory Cytokines under Hypoxic Conditions in Macrophages

(2011) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Hypoxia: a double-edged sword of immunity

(2011) Antonio Sica et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

(2011) Yukiji Takeda et al.   NATURE

Macrophages, Meta-Inflammation, and Immuno-Metabolism

(2011) Haim Shapiro et al.   TheScientificWorldJOURNAL

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Molecular mechanisms regulating macrophage response to hypoxia

(2011) Michal A. Rahat   Frontiers in Immunology

Opposing roles for HIF-1  and HIF-2  in the regulation of angiogenesis by mononuclear phagocytes

(2010) T. D. Eubank et al.   BLOOD

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Convergent pathways of macrophage polarization: The role of B cells

(2010) Antonio Sica et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role of NF-κB in Hypoxia-Induced Gene Expression

(2009) Cormac T. Taylor et al.   Annals of the New York Academy of Sciences

Inhibition of Prolyl Hydroxylase Domain-Containing Protein Suppressed Lipopolysaccharide-Induced TNF-α Expression

(2009) Kotaro Takeda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

(2009) H.-Y. Fang et al.   BLOOD

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

(2009) Martin Schneider et al.   GASTROENTEROLOGY

Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor

(2009) So Young Kim et al.   IMMUNOLOGY

Macrophage Oxygen Sensing Modulates Antigen Presentation and Phagocytic Functions Involving IFN-  Production through the HIF-1  Transcription Factor

(2009) B. Acosta-Iborra et al.   JOURNAL OF IMMUNOLOGY

Hypoxia Prolongs Monocyte/Macrophage Survival and Enhanced Glycolysis Is Associated with Their Maturation under Aerobic Conditions

(2009) J. Roiniotis et al.   JOURNAL OF IMMUNOLOGY

CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis

(2009) Yuanfan Wang et al.   Journal of Inflammation-London

The Hypoxic Synovial Environment Regulates Expression of Vascular Endothelial Growth Factor and Osteopontin in Juvenile Idiopathic Arthritis

(2009) M. C. BOSCO et al.   JOURNAL OF RHEUMATOLOGY

A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo

(2009) Y. A. Minamishima et al.   MOLECULAR AND CELLULAR BIOLOGY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

A2B adenosine receptors in immunity and inflammation

(2009) György Haskó et al.   TRENDS IN IMMUNOLOGY

Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice

(2008) Y. Sawanobori et al.   BLOOD

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Biology of hypoxia-inducible factor-2α in development and disease

(2008) S A Patel et al.   CELL DEATH AND DIFFERENTIATION

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

Macrophage roles following myocardial infarction

(2008) Jessica M. Lambert et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pulmonary arterial remodeling induced by a Th2 immune response

(2008) Eleen Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice

(2008) T. Bishop et al.   MOLECULAR AND CELLULAR BIOLOGY

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

(2007) Y. A. Minamishima et al.   BLOOD