Towards human exploration of space: The THESEUS review series on immunology research priorities

A case of persistent skin rash and rhinitis with immune system dysregulation onboard the International Space Station

(2016) Brian Crucian et al.   Journal of Allergy and Clinical Immunology-In Practice

The urodele amphibian Pleurodeles waltl has a diverse repertoire of immunoglobulin heavy chains with polyreactive and species-specific features

(2015) Coralie Fonte et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging

(2015) Chloé Lescale et al.   FASEB JOURNAL

Spaceflight alters expression of microRNA during T-cell activation

(2015) Millie Hughes-Fulford et al.   FASEB JOURNAL

Hypergravity exposure during gestation modifies the TCRβ repertoire of newborn mice

(2015) Stéphanie Ghislin et al.   Scientific Reports

Alterations in adaptive immunity persist during long-duration spaceflight

(2015) Brian Crucian et al.   NPJ Microgravity

Molecular cloning and expression analysis of Pleurodeles waltl complement component C3 under normal physiological conditions and environmental stresses

(2014) Nathan Guéguinou et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Plasma Cytokine Concentrations Indicate That In Vivo Hormonal Regulation of Immunity Is Altered During Long-Duration Spaceflight

(2014) Brian E. Crucian et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Three Weeks of Murine Hindlimb Unloading Induces Shifts from B to T and from Th to Tc Splenic Lymphocytes in Absence of Stress and Differentially Reduces Cell-Specific Mitogenic Responses

(2014) Fanny Gaignier et al.   PLoS One

Signal transduction in primary human T lymphocytes in altered gravity – results of the MASER-12 suborbital space flight mission

(2013) Svantje Tauber et al.   Cell Communication and Signaling

One night on-call: Sleep deprivation affects cardiac autonomic control and inflammation in physicians

(2013) Eleonora Tobaldini et al.   European Journal of Internal Medicine

Contribution of the urodele amphibian Pleurodeles waltl to the analysis of spaceflight-associated immune system deregulation

(2013) Jean-Pol Frippiat   MOLECULAR IMMUNOLOGY

Modulation of Pleurodeles waltl DNA Polymerase mu Expression by Extreme Conditions Encountered during Spaceflight

(2013) Véronique Schenten et al.   PLoS One

Changes of Cytokines during a Spaceflight Analog - a 45-Day Head-Down Bed Rest

(2013) Xi Xu et al.   PLoS One

Spaceflight Enhances Cell Aggregation and Random Budding in Candida albicans

(2013) Aurélie Crabbé et al.   PLoS One

Rapid alterations of cell cycle control proteins in human T lymphocytes in microgravity

(2012) Cora S. Thiel et al.   Cell Communication and Signaling

21 Days head-down bed rest induces weakening of cell-mediated immunity – Some spaceflight findings confirmed in a ground-based analog

(2012) Jens Kelsen et al.   CYTOKINE

Reactivation of latent viruses is associated with increased plasma cytokines in astronauts

(2012) S.K. Mehta et al.   CYTOKINE

5-Lipoxygenase-dependent apoptosis of human lymphocytes in the International Space Station: data from the ROALD experiment

(2012) Natalia Battista et al.   FASEB JOURNAL

Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis

(2012) Cécile Huin-Schohn et al.   FASEB JOURNAL

The Rel/NF-κB pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity

(2012) Tammy T. Chang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Monocyte Phenotype and Cytokine Production Profiles Are Dysregulated by Short-Duration Spaceflight

(2011) Brian Crucian et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

The Effects of Weightlessness on the Human Organism and Mammalian Cells

(2011) J. Pietsch et al.   CURRENT MOLECULAR MEDICINE

Space flight affects motility and cytoskeletal structures in human monocyte cell line J-111

(2011) Maria Antonia Meloni et al.   Cytoskeleton

How and why does the proteome respond to microgravity?

(2011) Daniela Grimm et al.   Expert Review of Proteomics

Decrease in antibody somatic hypermutation frequency under extreme, extended spaceflight conditions

(2011) Matthieu Bascove et al.   FASEB JOURNAL

Stress response and humoral immune system alterations related to chronic hypergravity in mice

(2011) Nathan Guéguinou et al.   PSYCHONEUROENDOCRINOLOGY

Transcriptional and Proteomic Responses ofPseudomonas aeruginosaPAO1 to Spaceflight Conditions Involve Hfq Regulation and Reveal a Role for Oxygen

(2010) Aurélie Crabbé et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Molecular characterization of Pleurodeles waltl activation-induced cytidine deaminase☆

(2010) Matthieu Bascove et al.   MOLECULAR IMMUNOLOGY

Motion Sickness, Stress and the Endocannabinoid System

(2010) Alexander Choukèr et al.   PLoS One

The response of Cupriavidus metallidurans CH34 to spaceflight in the international space station

(2009) Natalie Leys et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Immune Status, Latent Viral Reactivation, and Stress During Long-Duration Head-Down Bed Rest

(2009) Brian E. Crucian et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Parabolic flight primes cytotoxic capabilities of polymorphonuclear leucocytes in humans

(2009) I. Kaufmann et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Spaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl

(2009) Matthieu Bascove et al.   FASEB JOURNAL

Immune responses in adult female volunteers during the bed-rest model of spaceflight: Antibodies and cytokines

(2009) William T. Shearer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of spaceflight on innate immune function and antioxidant gene expression

(2009) Farnaz P. Baqai et al.   JOURNAL OF APPLIED PHYSIOLOGY

Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?

(2009) Nathan Guéguinou et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immune system dysregulation during spaceflight: clinical risk for exploration-class missions

(2009) Brian Crucian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Humoral and cellular immunity in cosmonauts after the ISS missions

(2008) M.P. Rykova et al.   ACTA ASTRONAUTICA

Immune System Dysregulation Following Short- vs Long-Duration Spaceflight

(2008) Brian E. Crucian et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Effect of Spaceflight on Ability of Monocytes To Respond to Endotoxins of Gram-Negative Bacteria

(2008) I. Kaur et al.   Clinical and Vaccine Immunology

IgX antibodies in the urodele amphibian Ambystoma mexicanum

(2008) Bérénice Schaerlinger et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Spaceflight effects on T lymphocyte distribution, function and gene expression

(2008) Daila S. Gridley et al.   JOURNAL OF APPLIED PHYSIOLOGY

Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts

(2008) Randall J. Cohrs et al.   JOURNAL OF MEDICAL VIROLOGY

Media Ion Composition Controls Regulatory and Virulence Response of Salmonella in Spaceflight

(2008) James W. Wilson et al.   PLoS One

A new isotype of immunoglobulin heavy chain in the urodele amphibian Pleurodeles waltl predominantly expressed in larvae

(2007) Bérénice Schaerlinger et al.   MOLECULAR IMMUNOLOGY