The Role of Extracellular Vesicles (EVs) in the Epigenetic Regulation of Bone Metabolism and Osteoporosis

The Osteocyte: New Insights

(2020) Alexander G. Robling et al.   Annual Review of Physiology

Evaluation of circulating miRNA-208a-3p, miRNA-155–5p and miRNA-637 as potential non-invasive biomarkers and the possible mechanistic insights into pre- and postmenopausal osteoporotic females

(2020) Suzan Magdy Ismail et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Comprehensive Analysis of lncRNA and miRNA Expression Profiles and ceRNA Network Construction in Osteoporosis

(2020) Xianzuo Zhang et al.   CALCIFIED TISSUE INTERNATIONAL

The Role of Mast Cells in Bone Metabolism and Bone Disorders

(2020) Deniz Ragipoglu et al.   Frontiers in Immunology

Exosomes derived from circRNA Rtn4-modified BMSCs attenuate TNF-α-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a

(2020) Guijun Cao et al.   BIOSCIENCE REPORTS

Muscle-organ crosstalk: the emerging roles of myokines

(2020) Mai Charlotte Krogh Severinsen et al.   ENDOCRINE REVIEWS

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exercise and Peak Bone Mass

(2020) Magnus K. Karlsson et al.   Current Osteoporosis Reports

Targeting senescent cells to attenuate cardiovascular disease progression

(2020) Ping Song et al.   AGEING RESEARCH REVIEWS

Effects of Different Types of Exercise on Bone Mineral Density in Postmenopausal Women: A Systematic Review and Meta-analysis

(2020) Wolfgang Kemmler et al.   CALCIFIED TISSUE INTERNATIONAL

Bone's Response to Mechanical Loading in Aging and Osteoporosis: Molecular Mechanisms

(2020) Valeria Carina et al.   CALCIFIED TISSUE INTERNATIONAL

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Muscle, Bone, and Fat Crosstalk: the Biological Role of Myokines, Osteokines, and Adipokines

(2020) Ben Kirk et al.   Current Osteoporosis Reports

Bone-Targeted Extracellular Vesicles from Mesenchymal Stem Cells for Osteoporosis Therapy

(2020) Yayu Wang et al.   International Journal of Nanomedicine

LncRNA ZBTB40-IT1 modulated by osteoporosis GWAS risk SNPs suppresses osteogenesis

(2019) Bing Mei et al.   HUMAN GENETICS

Osteoporosis

(2019) Juliet E Compston et al.   LANCET

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

(2019) Sadanand Fulzele et al.   Aging-US

Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis

(2019) D. Bellavia et al.   BONE

Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury

(2019) Lin-Li Lv et al.   CELL DEATH AND DIFFERENTIATION

EPC ‐derived exosomes promote osteoclastogenesis through Lnc RNA ‐ MALAT 1

(2019) Yigong Cui et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reversal of Osteoporotic Activity by Endothelial Cell-Secreted Bone Targeting and Biocompatible Exosomes

(2019) Hongyuan Song et al.   NANO LETTERS

MiR‐146a deletion protects from bone loss in OVX mice by suppressing RANKL/OPG and M‐CSF in bone microenvironment

(2019) Jingyu Zhao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Circulating Exosomes Derived-miR-146a from Systemic Lupus Erythematosus Patients Regulates Senescence of Mesenchymal Stem Cells

(2019) Chen Dong et al.   Biomed Research International

BMSC-derived exosomes carrying microRNA-122-5p promote proliferation of osteoblasts in osteonecrosis of the femoral head

(2019) Wen Liao et al.   CLINICAL SCIENCE

Tumour-Derived Extracellular Vesicles (EVs): A Dangerous “Message in A Bottle” for Bone

(2019) Alfredo Cappariello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis

(2019) Bartijn C. H. Pieters et al.   Frontiers in Immunology

LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c/SATB2 axis

(2019) Xucheng Yang et al.   Aging-US

Long non-coding RNA MALAT1 functions as miR-1 sponge to regulate Connexin 43-mediated ossification of the posterior longitudinal ligament

(2019) Xiaoqiu Yuan et al.   BONE

Extracellular Vesicles From Osteotropic Breast Cancer Cells Affect Bone Resident Cells

(2019) Alexander Loftus et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence

(2019) Jinsen Lu et al.   Scientific Reports

The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Mesothelioma With Bone Metastasis

(2019) Runzhi Huang et al.   Frontiers in Bioengineering and Biotechnology

Characterization of protein, long noncoding RNA and microRNA signatures in extracellular vesicles derived from resting and degranulated mast cells

(2019) Yuting Liang et al.   Journal of Extracellular Vesicles

Genome-wide association study of lncRNA polymorphisms with bone mineral density

(2018) Qin Zeng et al.   ANNALS OF HUMAN GENETICS

Engineered exosomes: A new promise for the management of musculoskeletal diseases

(2018) D. Bellavia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Longitudinal Effects of Teriparatide or Zoledronic Acid on Bone Modeling- and Remodeling-Based Formation in the SHOTZ Study

(2018) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis

(2018) Sundeep Khosla et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Endothelial cell senescence in aging-related vascular dysfunction

(2018) Guanghong Jia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Coupling of bone resorption and formation by RANKL reverse signalling

(2018) Yuki Ikebuchi et al.   NATURE

Long non‑coding RNA XIST promotes osteoporosis through inhibiting bone marrow mesenchymal stem cell differentiation

(2018) Xi Chen et al.   Experimental and Therapeutic Medicine

Long Non-coding RNAs: A New Regulatory Code for Osteoporosis

(2018) Qian-Yuan Wu et al.   Frontiers in Endocrinology

Exosomes: From Garbage Bins to Promising Therapeutic Targets

(2017) Mohammed H. Rashed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication

(2017) Yiwen Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoblast-Derived Extracellular Vesicles Are Biological Tools for the Delivery of Active Molecules to Bone

(2017) Alfredo Cappariello et al.   JOURNAL OF BONE AND MINERAL RESEARCH

miR-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting WISP2

(2017) Yan Zhang et al.   JOURNAL OF CELL SCIENCE

Gene regulation of mammalian long non-coding RNA

(2017) Heeyoun Bunch   MOLECULAR GENETICS AND GENOMICS

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

(2017) Kenneth G. Saag et al.   NEW ENGLAND JOURNAL OF MEDICINE

Estrogens and Androgens in Skeletal Physiology and Pathophysiology

(2017) Maria Almeida et al.   PHYSIOLOGICAL REVIEWS

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2

(2017) Kayvan Zainabadi et al.   PLoS One

X-inactive-specific transcript of peripheral blood cells is regulated by exosomal Jpx and acts as a biomarker for female patients with hepatocellular carcinoma

(2017) Xiang Ma et al.   Therapeutic Advances in Medical Oncology

LncRNA-H19 Modulates Wnt/β-catenin Signaling by Targeting Dkk4 in Hindlimb Unloaded Rat

(2017) Bing Li et al.   Orthopaedic Surgery

Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

(2017) Iain M. Dykes et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Annexin-enriched osteoblast-derived vesicles act as an extracellular site of mineral nucleation within developing stem cell cultures

(2017) O. G. Davies et al.   Scientific Reports

Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells

(2016) Sylvia Weilner et al.   AGING CELL

Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles

(2016) Sylvia Weilner et al.   Aging-US

Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

(2016) Baosheng Guo et al.   CALCIFIED TISSUE INTERNATIONAL

Exosomes from Human Synovial-Derived Mesenchymal Stem Cells Prevent Glucocorticoid-Induced Osteonecrosis of the Femoral Head in the Rat

(2016) Shang-Chun Guo et al.   International Journal of Biological Sciences

Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis

(2016) Paul D. Miller et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The roles of bone-derived exosomes and exosomal microRNAs in regulating bone remodelling

(2016) Yong Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Local regulation of gene expression by lncRNA promoters, transcription and splicing

(2016) Jesse M. Engreitz et al.   NATURE

Unique features of long non-coding RNA biogenesis and function

(2016) Jeffrey J. Quinn et al.   NATURE REVIEWS GENETICS

Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol

(2016) Howard N. Hodis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

(2016) Weijia Sun et al.   Cell Discovery

Bone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis

(2016) Bente Langdahl et al.   Therapeutic Advances in Musculoskeletal Disease

H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA

(2016) Wei-Cheng Liang et al.   Scientific Reports

Biotechnological approach for systemic delivery of membrane Receptor Activator of NF-κB Ligand (RANKL) active domain into the circulation

(2015) Alfredo Cappariello et al.   BIOMATERIALS

Adipogenic RNAs are transferred in osteoblasts via bone marrow adipocytes-derived extracellular vesicles (EVs)

(2015) Perrine J Martin et al.   BMC CELL BIOLOGY

Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease

(2015) James A. Carson et al.   BONE

Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation

(2015) Sylvia Weilner et al.   BONE

Osteoblast-derived microvesicles: A novel mechanism for communication between osteoblasts and osteoclasts

(2015) Lili Deng et al.   BONE

Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expression

(2015) Yazhou Cui et al.   FEBS LETTERS

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Relationship of sarcopenia and body composition with osteoporosis

(2015) H. He et al.   OSTEOPOROSIS INTERNATIONAL

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

(2015) Georgia K. Atkin-Smith et al.   Nature Communications

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

(2015) Margaret Alexander et al.   Nature Communications

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Reprint of: The Great Beauty of the osteoclast

(2014) Alfredo Cappariello et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Plasma miRNA levels correlate with sensitivity to bone mineral density in postmenopausal osteoporosis patients

(2014) Hongqiu Li et al.   BIOMARKERS

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

(2014) T. Umezu et al.   BLOOD

Myostatin and Sarcopenia: Opportunities and Challenges - A Mini-Review

(2014) Thomas A. White et al.   GERONTOLOGY

Five Freely Circulating miRNAs and Bone Tissue miRNAs Are Associated With Osteoporotic Fractures

(2014) Claudine Seeliger et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Long non-coding RNA in health and disease

(2014) Philipp G. Maass et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study

(2014) Pieter Mestdagh et al.   NATURE METHODS

Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

(2014) Ji-Feng Xu et al.   PLoS One

Non-coding RNAs as direct and indirect modulators of epigenetic regulation

(2013) Veronica J Peschansky et al.   Epigenetics

Long Noncoding RNAs: Past, Present, and Future

(2013) J. T. Y. Kung et al.   GENETICS

Quantification of Circulating miRNAs in Plasma

(2013) Ioanna S. Sourvinou et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

PIWI-interacting RNAs: from generation to transgenerational epigenetics

(2013) Maartje J. Luteijn et al.   NATURE REVIEWS GENETICS

Structure and function of long noncoding RNAs in epigenetic regulation

(2013) Tim R Mercer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An experimental therapy to improve skeletal growth and prevent bone loss in a mouse model overexpressing IL-6

(2013) A. Del Fattore et al.   OSTEOPOROSIS INTERNATIONAL

Plasma Processing Conditions Substantially Influence Circulating microRNA Biomarker Levels

(2013) Heather H. Cheng et al.   PLoS One

The Role of Vitamin D in Blood Pressure, Endothelial and Renal Function in Postmenopausal Women

(2013) Zhao-Min Liu et al.   Nutrients

Bisphosphonate Therapy for Osteoporosis: Benefits, Risks, and Drug Holiday

(2012) Michael McClung et al.   AMERICAN JOURNAL OF MEDICINE

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

Genetics of osteoporosis from genome-wide association studies: advances and challenges

(2012) J. Brent Richards et al.   NATURE REVIEWS GENETICS

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

(2012) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

XenomiRs and miRNA homeostasis in health and disease

(2012) Kenneth W. Witwer   RNA Biology

Analytical challenges and technical limitations in assessing circulating MiRNAs

(2012) Manuel Mayr et al.   THROMBOSIS AND HAEMOSTASIS

Plasma Components Affect Accuracy of Circulating Cancer-Related MicroRNA Quantitation

(2011) Dong-Ja Kim et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training

(2011) Aaron L. Baggish et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Expression and Rhythmic Modulation of Circulating MicroRNAs Targeting the Clock Gene Bmal1 in Mice

(2011) Vikram R. Shende et al.   PLoS One

Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation

(2010) Rumiko Ogawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adipocyte-Derived Microvesicles Are Associated with Multiple Angiogenic Factors and Induce Angiogenesisin Vivoandin Vitro

(2010) Naohito Aoki et al.   ENDOCRINOLOGY

Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study

(2010) Roger MD Zebaze et al.   LANCET

Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR)

(2010) Evan M. Kroh et al.   METHODS

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Evolution and Functions of Long Noncoding RNAs

(2009) Chris P. Ponting et al.   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Molecular mechanisms of late apoptotic/necrotic cell clearance

(2009) I K H Poon et al.   CELL DEATH AND DIFFERENTIATION

Committed osteoclast precursors colonize the bone and improve the phenotype of a mouse model of autosomal recessive osteopetrosis

(2009) Alfredo Cappariello et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis

(2009) Steven R. Cummings et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis

(2008) Marcel Scheideler et al.   BMC GENOMICS

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

Mechanisms of endothelial senescence

(2008) Jorge D. Erusalimsky et al.   EXPERIMENTAL PHYSIOLOGY

The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

(2008) Katsutomo Okamura et al.   NATURE

A microRNA signature for a BMP2-induced osteoblast lineage commitment program

(2008) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Eukaryotic Genome as an RNA Machine

(2008) P. P. Amaral et al.   SCIENCE

Non-coding RNAs, epigenetics and complexity

(2007) Fabrício F. Costa   GENE