Extracellular Vesicles in Viral Pathogenesis: A Case of Dr. Jekyll and Mr. Hyde

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Exosome-Mediated Transfer of ACE2 (Angiotensin-Converting Enzyme 2) from Endothelial Progenitor Cells Promotes Survival and Function of Endothelial Cell

(2020) Jinju Wang et al.   Oxidative Medicine and Cellular Longevity

Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles

(2020) Wang Jiang et al.   Journal of Extracellular Vesicles

COVID-19 and the Heart

(2020) Akbarshakh Akhmerov et al.   CIRCULATION RESEARCH

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

Albumin-impregnated bone granules modulate the interactions between mesenchymal stem cells and monocytes under in vitro inflammatory conditions

(2020) Eitan Mijiritsky et al.   Materials Science & Engineering C-Materials for Biological Applications

Next generation sequencing‑based analysis of mitochondrial DNA characteristics in plasma extracellular vesicles of patients with hepatocellular carcinoma

(2020) Yijie Li et al.   Oncology Letters

Connexins and Integrins in Exosomes

(2019) Motomu Shimaoka et al.   Cancers

Host Determinants of MERS-CoV Transmission and Pathogenesis

(2019) W. Widagdo et al.   Viruses-Basel

Freeze-dried and GMP-compliant pharmaceuticals containing exosomes for acellular mesenchymal stromal cell immunomodulant therapy

(2019) Elia Bari et al.   Nanomedicine

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion

(2019) Eman A. Taha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of nuclear content loading to exosomes

(2019) Akira Yokoi et al.   Science Advances

Actin and Actin-Associated Proteins in Extracellular Vesicles Shed by Osteoclasts

(2019) L. Shannon Holliday et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intrinsic Immunity Shapes Viral Resistance of Stem Cells

(2018) Xianfang Wu et al.   CELL

Exosomes and Ectosomes in Intercellular Communication

(2018) Jacopo Meldolesi   CURRENT BIOLOGY

Extracellular Vesicles as Conveyors of Membrane-Derived Bioactive Lipids in Immune System

(2018) Krizia Sagini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lung-Derived Exosomal miR-483-3p Regulates the Innate Immune Response to Influenza Virus Infection

(2018) Tadashi Maemura et al.   JOURNAL OF INFECTIOUS DISEASES

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

(2018) Daniel Torralba et al.   Nature Communications

Exosome Theranostics: Biology and Translational Medicine

(2018) Chuanjiang He et al.   Theranostics

Exosomes and Immune Response in Cancer: Friends or Foes?

(2018) Francisco M. Barros et al.   Frontiers in Immunology

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

(2018) Sarah Caruso et al.   Frontiers in Immunology

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

Bioprocessing of Mesenchymal Stem Cells and Their Derivatives: Toward Cell-Free Therapeutics

(2018) Jolene Phelps et al.   Stem Cells International

Oncogenic H-Ras Expression Induces Fatty Acid Profile Changes in Human Fibroblasts and Extracellular Vesicles

(2018) Krizia Sagini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

(2018) Mohashin Pathan et al.   NUCLEIC ACIDS RESEARCH

Extracellular Vesicles in Herpes Viral Spread and Immune Evasion

(2018) Raquel Bello-Morales et al.   Frontiers in Microbiology

Current status of therapeutic and vaccine approaches against Zika virus

(2017) Braira Wahid et al.   European Journal of Internal Medicine

Epstein-Barr Virus LMP1-Mediated Oncogenicity

(2017) Liang Wei Wang et al.   JOURNAL OF VIROLOGY

Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling

(2017) Qiyu Wang et al.   Nature Communications

Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue

(2017) Anush Arakelyan et al.   Scientific Reports

The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases

(2017) James T. Earnest et al.   PLoS Pathogens

RNA in extracellular vesicles

(2017) Kyoung Mi Kim et al.   Wiley Interdisciplinary Reviews-RNA

MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair

(2017) Lianbo Shao et al.   Biomed Research International

TAX1BP1 downregulation by EBV-miR-BART15-3p enhances chemosensitivity of gastric cancer cells to 5-FU

(2016) Hoyun Choi et al.   ARCHIVES OF VIROLOGY

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

(2016) Erik R. Abels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection

(2016) Wojciech Cypryk et al.   JOURNAL OF PROTEOME RESEARCH

Herpes Simplex Virus Capsid Localization to ESCRT-VPS4 Complexes in the Presence and Absence of the Large Tegument Protein UL36p

(2016) Himanshu Kharkwal et al.   JOURNAL OF VIROLOGY

CD63 Regulates Epstein-Barr Virus LMP1 Exosomal Packaging, Enhancement of Vesicle Production, and Noncanonical NF-κB Signaling

(2016) Stephanie N. Hurwitz et al.   JOURNAL OF VIROLOGY

Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery

(2016) Helena M. van Dongen et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis

(2016) Sayantan Maji et al.   MOLECULAR CANCER RESEARCH

Exosomes in Viral Disease

(2016) Monique R. Anderson et al.   Neurotherapeutics

Extracellular vesicles and viruses: Are they close relatives?

(2016) Esther Nolte-‘t Hoen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-H28 and miR-H29 expressed late in productive infection are exported and restrict HSV-1 replication and spread in recipient cells

(2016) Zhiyuan Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicles during Herpes Simplex Virus type 1 infection: an inquire

(2016) Maria Kalamvoki et al.   Virology Journal

Biliary Secretion of Quasi-Enveloped Human Hepatitis A Virus

(2016) Asuka Hirai-Yuki et al.   mBio

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

SARS-CoV fusion peptides induce membrane surface ordering and curvature

(2016) Luis G. M. Basso et al.   Scientific Reports

L Particles Transmit Viral Proteins from Herpes Simplex Virus 1-Infected Mature Dendritic Cells to Uninfected Bystander Cells, Inducing CD83 Downmodulation

(2015) Christiane S. Heilingloh et al.   JOURNAL OF VIROLOGY

Exosomal Communication Goes Viral

(2015) David G. Meckes   JOURNAL OF VIROLOGY

The cell secretome, a mediator of cell-to-cell communication

(2015) Joseph Zullo et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

(2015) Georgia K. Atkin-Smith et al.   Nature Communications

EVpedia: a community web portal for extracellular vesicles research

(2014) D.-K. Kim et al.   BIOINFORMATICS

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection

(2014) Xun Zhu et al.   CELLULAR MICROBIOLOGY

Exosomes and other extracellular vesicles in host-pathogen interactions

(2014) J. S. Schorey et al.   EMBO REPORTS

Exosomes from Bronchoalveolar Fluid of Tolerized Mice Prevent Allergic Reaction

(2014) N. Prado et al.   JOURNAL OF IMMUNOLOGY

Cytomegalovirus-Infected Human Endothelial Cells Can Stimulate Allogeneic CD4+ Memory T Cells by Releasing Antigenic Exosomes

(2014) J. D. Walker et al.   JOURNAL OF IMMUNOLOGY

Microvesicles: ubiquitous contributors to infection and immunity

(2014) Frances W. Lai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Exosomes from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells License Quiescent CD4+ T Lymphocytes To Replicate HIV-1 through a Nef- and ADAM17-Dependent Mechanism

(2014) C. Arenaccio et al.   JOURNAL OF VIROLOGY

Proteomics of extracellular vesicles: Exosomes and ectosomes

(2014) Dong-Sic Choi et al.   MASS SPECTROMETRY REVIEWS

Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes

(2014) M Aga et al.   ONCOGENE

Epstein-Barr Virus-Encoded Small RNAs (EBERs) Are Present in Fractions Related to Exosomes Released by EBV-Transformed Cells

(2014) Waqar Ahmed et al.   PLoS One

Novel HIV-1 MiRNAs Stimulate TNFα Release in Human Macrophages via TLR8 Signaling Pathway

(2014) Mark A. Bernard et al.   PLoS One

Nef Neutralizes the Ability of Exosomes from CD4+ T Cells to Act as Decoys during HIV-1 Infection

(2014) Julianne V. de Carvalho et al.   PLoS One

Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs

(2014) Maria Kalamvoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90

(2014) Terence N. Bukong et al.   PLoS Pathogens

Innate Immune Response of Human Alveolar Type II Cells Infected with Severe Acute Respiratory Syndrome–Coronavirus

(2013) Zhaohui Qian et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

(2013) Alicia Llorente et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Exosomes released in vitro from Epstein–Barr virus (EBV)-infected cells contain EBV-encoded latent phase mRNAs

(2013) Andrea Canitano et al.   CANCER LETTERS

Virus Budding and the ESCRT Pathway

(2013) Jörg Votteler et al.   Cell Host & Microbe

Exosomes Derived from HIV-1-infected Cells Contain Trans-activation Response Element RNA

(2013) Aarthi Narayanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Epstein-Barr Virus-Encoded MicroRNA BART15-3p Promotes Cell Apoptosis Partially by Targeting BRUCE

(2013) H. Choi et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

(2013) R. J. de Groot et al.   JOURNAL OF VIROLOGY

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes

(2013) Zongdi Feng et al.   NATURE

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Human placental trophoblasts confer viral resistance to recipient cells

(2013) E. Delorme-Axford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells

(2013) V. Ramakrishnaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of B-cell exosome proteins by gamma herpesvirus infection

(2013) D. G. Meckes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

Hrs- and CD63-Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

(2013) James R. Edgar et al.   TRAFFIC

Systemically Circulating Viral and Tumor-Derived MicroRNAs in KSHV-Associated Malignancies

(2013) Pauline E. Chugh et al.   PLoS Pathogens

Exosomes as nucleic acid nanocarriers

(2012) Jasper G. van den Boorn et al.   ADVANCED DRUG DELIVERY REVIEWS

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

(2012) Marlène Dreux et al.   Cell Host & Microbe

Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease

(2012) Sudhir H. Ranganath et al.   Cell Stem Cell

Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1  Production

(2012) M. Haneklaus et al.   JOURNAL OF IMMUNOLOGY

Get on the exosome bus with ALIX

(2012) James H. Hurley et al.   NATURE CELL BIOLOGY

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

Cardiomyocyte Microvesicles Contain DNA/RNA and Convey Biological Messages to Target Cells

(2012) Anders Waldenström et al.   PLoS One

Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein

(2012) Sandrine Belouzard et al.   Viruses-Basel

The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines

(2012) Rebecca L. Skalsky et al.   PLoS Pathogens

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation

(2011) Frederik J Verweij et al.   EMBO JOURNAL

Microvesicles and Viral Infection

(2011) D. G. Meckes et al.   JOURNAL OF VIROLOGY

Secretion Modification Region-Derived Peptide Disrupts HIV-1 Nef's Interaction with Mortalin and Blocks Virus and Nef Exosome Release

(2011) M. N. Shelton et al.   JOURNAL OF VIROLOGY

Direct and Specific Binding of the UL16 Tegument Protein of Herpes Simplex Virus to the Cytoplasmic Tail of Glycoprotein E

(2011) P.-C. Yeh et al.   JOURNAL OF VIROLOGY

Dynamics of ESCRT protein recruitment during retroviral assembly

(2011) Nolwenn Jouvenet et al.   NATURE CELL BIOLOGY

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Virus-encoded microRNAs

(2011) Adam Grundhoff et al.   VIROLOGY

Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway

(2011) Keiichi Tamai et al.   VIROLOGY

Packaging of Non-Coding RNAs into Herpesvirus Virions: Comparisons to Coding RNAs

(2011) Melanie A. Amen et al.   Frontiers in Genetics

Exosomes and other microvesicles in infection biology: organelles with unanticipated phenotypes

(2010) Judith Maxwell Silverman et al.   CELLULAR MICROBIOLOGY

Exosomes and retroviruses: the chicken or the egg?

(2010) Nuria Izquierdo-Useros et al.   CELLULAR MICROBIOLOGY

Paramyxovirus assembly and budding: Building particles that transmit infections

(2010) Megan S. Harrison et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Exosome-Driven Antigen Transfer for MHC Class II Presentation Facilitated by the Receptor Binding Activity of Influenza Hemagglutinin

(2010) J. S. Testa et al.   JOURNAL OF IMMUNOLOGY

Exosomes Containing Glycoprotein 350 Released by EBV-Transformed B Cells Selectively Target B Cells through CD21 and Block EBV Infection In Vitro

(2010) H. Vallhov et al.   JOURNAL OF IMMUNOLOGY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission

(2010) C. L. Brimacombe et al.   JOURNAL OF VIROLOGY

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

(2010) Nanhai He et al.   MOLECULAR CELL

Human tumor virus utilizes exosomes for intercellular communication

(2010) D. G. Meckes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples

(2010) Javier Conde-Vancells et al.   Proteomics Clinical Applications

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

(2009) Claudia Muratori et al.   Cell Host & Microbe

The Cell Biology of HIV-1 Virion Genesis

(2009) Paul D. Bieniasz   Cell Host & Microbe

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

(2009) Mehmet Kesimer et al.   FASEB JOURNAL

The ESCRT machinery at a glance

(2009) T. Wollert et al.   JOURNAL OF CELL SCIENCE

The Herpes Simplex Virus-1 Encoded Glycoprotein B Diverts HLA-DR into the Exosome Pathway

(2009) Sebastian Temme et al.   JOURNAL OF IMMUNOLOGY

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits

(2009) Weifeng Xu et al.   NATURE IMMUNOLOGY

Exosomes from human saliva as a source of microRNA biomarkers

(2009) A Michael et al.   ORAL DISEASES

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

Functional roles of the tegument proteins of herpes simplex virus type 1

(2009) Barbara J. Kelly et al.   VIRUS RESEARCH

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

EBV MicroRNAs in Primary Lymphomas and Targeting of CXCL-11 by ebv-mir-BHRF1-3

(2008) T. Xia et al.   CANCER RESEARCH

Imaging and imagination: understanding the endo-lysosomal system

(2008) Eline Meel et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Discrimination between exosomes and HIV-1: Purification of both vesicles from cell-free supernatants

(2008) Réjean Cantin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Exosomes Packaging APOBEC3G Confer Human Immunodeficiency Virus Resistance to Recipient Cells

(2008) A. K. Khatua et al.   JOURNAL OF VIROLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

Human Herpesvirus-6 Induces MVB Formation, and Virus Egress Occurs by an Exosomal Release Pathway

(2008) Yasuko Mori et al.   TRAFFIC

The HIV-1 Vif PPLP motif is necessary for human APOBEC3G binding and degradation

(2008) John P. Donahue et al.   VIROLOGY

Mechanisms for enveloped virus budding: Can some viruses do without an ESCRT?

(2007) Benjamin J. Chen et al.   VIROLOGY