Gasdermin D Drives the Nonexosomal Secretion of Galectin-3, an Insulin Signal Antagonist

Recent advances in inflammasome biology

(2018) David E Place et al.   CURRENT OPINION IN IMMUNOLOGY

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z

(2018) Salvatore Sciacchitano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes

(2018) Brendan M. Everett et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Molecular mechanism to recruit galectin-3 into multivesicular bodies for polarized exosomal secretion

(2018) Sebastian Bänfer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of Macrophage Exosomes in Immune Response to Calcium Oxalate Monohydrate Crystals

(2018) Nilubon Singhto et al.   Frontiers in Immunology

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

(2018) Ishita Banerjee et al.   IMMUNITY

The role of galectin-3 in heart failure and cardiovascular disease

(2018) Xiao Zhong et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

(2017) Yutao Wang et al.   IMMUNITY

A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface

(2017) Sarah E. Stewart et al.   JOURNAL OF CELL SCIENCE

Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling–Induced Nontranscriptional Priming of the NLRP3 Inflammasome

(2017) Yue Xing et al.   JOURNAL OF IMMUNOLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Inflammasome-Dependent Cytokines at the Crossroads of Health and Autoinflammatory Disease

(2017) Hanne Van Gorp et al.   Cold Spring Harbor Perspectives in Biology

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers

(2017) Laetitia Seguin et al.   Cancer Discovery

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

(2016) Pingping Li et al.   CELL

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

(2016) F Martín-Sánchez et al.   CELL DEATH AND DIFFERENTIATION

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages

(2016) Elina Välimäki et al.   JOURNAL OF IMMUNOLOGY

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides

(2016) Hana M. Russo et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Derived Exosomes Activate NF-κB Signaling in Macrophages

(2016) Yuehui Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance

(2015) Dov B. Ballak et al.   CYTOKINE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3

(2015) Fei Fei et al.   Oncotarget

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

(2015) Miguel Angel Burguillos et al.   Cell Reports

Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity

(2013) Marc Y. Donath et al.   Cell Metabolism

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies

(2013) Susannah D. Brydges et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family

(2012) Cees J. Tack et al.   IMMUNOLOGICAL REVIEWS

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice

(2011) Vladislav Volarevic et al.   HEPATOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Galectin-3 Exerts Cytokine-Like Regulatory Actions through the JAK-STAT Pathway

(2010) S.-B. Jeon et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Proteomics Analysis of Bladder Cancer Exosomes

(2010) Joanne L. Welton et al.   MOLECULAR & CELLULAR PROTEOMICS

Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity

(2009) Susannah D. Brydges et al.   IMMUNITY

A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses

(2009) Guangxun Meng et al.   IMMUNITY

The Role of Galectins in Protein Trafficking

(2009) Delphine Delacour et al.   TRAFFIC

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL