New Trends in Pharmacological Treatments for Osteoarthritis

Effect of ultrasound-detected synovitis on therapeutic efficacy of hyaluronic acid injection for symptomatic knee osteoarthritis

(2021) Chien-Chih Wang et al.   RHEUMATOLOGY

Intra-articular sprifermin reduces cartilage loss in addition to increasing cartilage gain independent of location in the femorotibial joint: post-hoc analysis of a randomised, placebo-controlled phase II clinical trial

(2020) Felix Eckstein et al.   ANNALS OF THE RHEUMATIC DISEASES

Pharmacotherapy for knee osteoarthritis: current and emerging therapies

(2020) Peihua Cao et al.   EXPERT OPINION ON PHARMACOTHERAPY

Metformin limits osteoarthritis development and progression through activation of AMPK signalling

(2020) Jun Li et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions

(2020) Guoqi Cai et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of vitamin D supplementation on disabling foot pain in patients with symptomatic knee osteoarthritis

(2020) Liudan Tu et al.   ARTHRITIS CARE & RESEARCH

Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee Osteoarthritis

(2020) Zhiqiang Wang et al.   ANNALS OF INTERNAL MEDICINE

The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo

(2020) Anne Sofie Siebuhr et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peripheral pain mechanisms in osteoarthritis

(2020) Tonia L. Vincent   PAIN

Can low-dose methotrexate reduce effusion-synovitis and symptoms in patients with mid- to late-stage knee osteoarthritis? Study protocol for a randomised, double-blind, and placebo-controlled trial

(2020) Zhaohua Zhu et al.   Trials

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

(2020) Philip R. Coryell et al.   Nature Reviews Rheumatology

Concept Endpoints Informing Design Considerations for Confirmatory Clinical Trials in Osteoarthritis

(2020) Yura Kim et al.   ARTHRITIS CARE & RESEARCH

Osteoarthritis year in review 2020: epidemiology & therapy

(2020) G. Peat et al.   OSTEOARTHRITIS AND CARTILAGE

A Phase 2 Trial of Lutikizumab, an Anti-Interleukin 1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis

(2019) Roy M. Fleischmann et al.   Arthritis & Rheumatology

Anti-IL-1 for the treatment of OA: dead or alive?

(2019) Xavier Chevalier et al.   Nature Reviews Rheumatology

Safety of Opioids in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis

(2019) Nicholas Fuggle et al.   DRUGS & AGING

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee

(2019) Thomas J. Schnitzer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

(2019) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

A machine learning approach to knee osteoarthritis phenotyping: data from the FNIH Biomarkers Consortium

(2019) A.E. Nelson et al.   OSTEOARTHRITIS AND CARTILAGE

The Efficacy, Tolerability and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Double-blind, Placebo-controlled, Randomized Clinical Trial

(2019) Paula Dakin et al.   Arthritis & Rheumatology

Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis

(2019) A.K. Carlson et al.   OSTEOARTHRITIS AND CARTILAGE

Etanercept therapy leads to reductions in matrix metalloproteinase-3 in patients with erosive hand osteoarthritis

(2019) FPB Kroon et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis

(2019) Marc C. Hochberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis

(2019) Philip G. Conaghan et al.   ANNALS OF INTERNAL MEDICINE

Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis

(2018) Sarah R. Kingsbury et al.   ANNALS OF INTERNAL MEDICINE

Safety profile of the interleukin-1 inhibitors anakinra and canakinumab in real-life clinical practice: a nationwide multicenter retrospective observational study

(2018) Jurgen Sota et al.   CLINICAL RHEUMATOLOGY

Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain

(2018) Philip G. Conaghan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Senescent cells and osteoarthritis: a painful connection

(2018) Ok Hee Jeon et al.   JOURNAL OF CLINICAL INVESTIGATION

The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

(2018) Erik Lindström et al.   Journal of Translational Medicine

Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711

(2018) Erik Lindström et al.   Journal of Translational Medicine

Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)

(2018) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee

(2018) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis – the HUMOR trial

(2018) D. Aitken et al.   OSTEOARTHRITIS AND CARTILAGE

Are bisphosphonates efficacious in knee osteoarthritis? A meta-analysis of randomized controlled trials

(2018) E.E. Vaysbrot et al.   OSTEOARTHRITIS AND CARTILAGE

Combination COX-2 inhibitor and metformin attenuate rate of joint replacement in osteoarthritis with diabetes: A nationwide, retrospective, matched-cohort study in Taiwan

(2018) Chieh-Hua Lu et al.   PLoS One

What is new in pain modification in osteoarthritis?

(2018) Rachel E Miller et al.   RHEUMATOLOGY

A Multicenter, Double-Blind, Phase III Clinical Trial to Evaluate the Efficacy and Safety of a Cell and Gene Therapy in Knee Osteoarthritis Patients

(2018) Myung-Ku Kim et al.   Human Gene Therapy Clinical Development

Sprifermin treatment enhances cartilage integration in an in vitro repair model

(2018) Mackenzie L. Sennett et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial

(2018) Margreet Kloppenburg et al.   ANNALS OF THE RHEUMATIC DISEASES

Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis

(2018) Margreet Kloppenburg et al.   ANNALS OF THE RHEUMATIC DISEASES

Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics

(2018) Win Min Oo et al.   EXPERT OPINION ON EMERGING DRUGS

Effect of Vitamin D Supplementation on Depressive Symptoms in Patients With Knee Osteoarthritis

(2018) Shuang Zheng et al.   Journal of the American Medical Directors Association

Mechanical stress contributes to osteoarthritis development through the activation of transforming growth factor beta 1 (TGF-β1)

(2018) R-K. Zhang et al.   Bone & Joint Research

Strontium ranelate, a promising disease modifying osteoarthritis drug

(2017) Weiyu Han et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized clinical trials

(2017) Igho J. Onakpoya et al.   International Journal of Rheumatic Diseases

Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis

(2017) Timothy E. McAlindon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo

(2017) Ditte Reker et al.   Journal of Translational Medicine

Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis

(2017) Bruno R da Costa et al.   LANCET

Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1β is mediated by curcumin via inhibition of NF-κB signaling in rat chondrocytes

(2017) Jian Wang et al.   Molecular Medicine Reports

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Anti-NGF treatments for pain — two steps forward, one step back?

(2017) Nancy E. Lane et al.   Nature Reviews Rheumatology

Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix

(2017) A. Gigout et al.   OSTEOARTHRITIS AND CARTILAGE

A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study

(2017) Y. Yazici et al.   OSTEOARTHRITIS AND CARTILAGE

Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis

(2017) X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study

(2017) S.X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Efficacy of hydroxychloroquine in hand osteoarthritis: a randomized, double blind, placebo-controlled trial

(2017) Weiching Lee et al.   ARTHRITIS CARE & RESEARCH

Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data

(2017) Michèle Bally et al.   BMJ-British Medical Journal

Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data

(2017) Michèle Bally et al.   BMJ-British Medical Journal

Brief Report: A Phase IIb Trial of a Novel Extended-Release Microsphere Formulation of Triamcinolone Acetonide for Intraarticular Injection in Knee Osteoarthritis

(2017) Philip G. Conaghan et al.   Arthritis & Rheumatology

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

(2017) Di Chen et al.   Bone Research

Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial

(2016) Frank W. Roemer et al.   BMC MUSCULOSKELETAL DISORDERS

Tanezumab in the treatment of chronic musculoskeletal conditions

(2016) Prakash Jayabalan et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis

(2016) Xingzhong Jin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis

(2016) R.E. Miller et al.   OSTEOARTHRITIS AND CARTILAGE

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

(2016) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Efficacy and Safety of Tanezumab on Osteoarthritis Knee and Hip Pains: A Meta-Analysis of Randomized Controlled Trials

(2016) Junyuan Chen et al.   PAIN MEDICINE

When Is Osteonecrosis Not Osteonecrosis?: Adjudication of Reported Serious Adverse Joint Events in the Tanezumab Clinical Development Program

(2016) Marc C. Hochberg et al.   Arthritis & Rheumatology

Protective effects of tumor necrosis factor-α blockade by adalimumab on articular cartilage and subchondral bone in a rat model of osteoarthritis

(2015) C.H. Ma et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis

(2015) Le T. Duong et al.   CALCIFIED TISSUE INTERNATIONAL

Possible chondroprotective effect of canakinumab: An in vitro study on human osteoarthritic chondrocytes

(2015) Sara Cheleschi et al.   CYTOKINE

Wnt signaling in cartilage development and diseases: lessons from animal studies

(2015) Yu Usami et al.   LABORATORY INVESTIGATION

Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β

(2015) Susan E Lacy et al.   mAbs

Interleukin-1 function and role in rheumatic disease

(2015) Georg Schett et al.   Nature Reviews Rheumatology

Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis

(2015) S. Thysen et al.   OSTEOARTHRITIS AND CARTILAGE

Recommendations for an update of the 2010 European regulatory guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis and reflections about related clinically relevant outcomes: expert consensus statement

(2015) J.-Y. Reginster et al.   OSTEOARTHRITIS AND CARTILAGE

Serious joint-related adverse events in randomized controlled trials of anti-nerve growth factor monoclonal antibodies

(2015) M.C. Hochberg   OSTEOARTHRITIS AND CARTILAGE

Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials

(2015) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Preliminary results of a phase II randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing TGF-β1 in patients with grade 3 chronic degenerative joint disease of the knee

(2015) J.J. Cherian et al.   OSTEOARTHRITIS AND CARTILAGE

Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification

(2015) J. Larkin et al.   OSTEOARTHRITIS AND CARTILAGE

Plain radiography or magnetic resonance imaging (MRI): Which is better in assessing outcome in clinical trials of disease-modifying osteoarthritis drugs? Summary of a debate held at the World Congress of Osteoarthritis 2014

(2015) Felix Eckstein et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial

(2015) Sarah R Kingsbury et al.   Trials

Efficacy of Direct Injection of Etanercept into Knee Joints for Pain in Moderate and Severe Knee Osteoarthritis

(2015) Seiji Ohtori et al.   YONSEI MEDICAL JOURNAL

Brief Report: Intraarticular Sprifermin Not Only Increases Cartilage Thickness, but Also Reduces Cartilage Loss: Location-Independent Post Hoc Analysis Using Magnetic Resonance Imaging

(2015) Felix Eckstein et al.   Arthritis & Rheumatology

Editorial: Inflammatory Activity in Symptomatic Knee Osteoarthritis: Not All Inflammation Is Local

(2015) Carla R. Scanzello et al.   Arthritis & Rheumatology

A Multicenter, Single-Blind, Phase IIa Clinical Trial to Evaluate the Efficacy and Safety of a Cell-Mediated Gene Therapy in Degenerative Knee Arthritis Patients

(2015) Chul-Won Ha et al.   Human Gene Therapy Clinical Development

Retracted: Methotrexate in the treatment of symptomatic knee osteoarthritis: randomised placebo-controlled trial

(2014) A Abou-Raya et al.   ANNALS OF THE RHEUMATIC DISEASES

Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a randomised, multicentre, double-blind, placebo-controlled trial

(2014) X Chevalier et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis joint pain: The cytokine connection

(2014) Rachel E. Miller et al.   CYTOKINE

A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry

(2014) Yu Cao et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Sprifermin shows cartilage-protective effects in knee OA

(2014) Sarah Onuora   Nature Reviews Rheumatology

Intraarticular Sprifermin (Recombinant Human Fibroblast Growth Factor 18) in Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial

(2014) L. Stefan Lohmander et al.   Arthritis & Rheumatology

Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model

(2013) De-gang Yu et al.   ACTA PHARMACOLOGICA SINICA

Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss

(2013) Jean-Pierre Pelletier et al.   ANNALS OF THE RHEUMATIC DISEASES

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

(2013) M A Karsdal et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis

(2013) Timothy McAlindon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

To Wnt or not to Wnt: the bone and joint health dilemma

(2013) Rik J. Lories et al.   Nature Reviews Rheumatology

Towards a mechanism-based approach to pain management in osteoarthritis

(2013) Anne-Marie Malfait et al.   Nature Reviews Rheumatology

Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis

(2013) R. Chiusaroli et al.   OSTEOARTHRITIS AND CARTILAGE

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial

(2012) Jean-Yves Reginster et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients

(2012) Chul-Won Ha et al.   CYTOTHERAPY

The pharmacology of curcumin: is it the degradation products?

(2012) Liang Shen et al.   TRENDS IN MOLECULAR MEDICINE

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification

(2011) Gust Verbruggen et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic evidence of the regulatory role of parathyroid hormone-related protein in articular chondrocyte maintenance in an experimental mouse model

(2011) Carolyn Macica et al.   ARTHRITIS AND RHEUMATISM

Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee

(2011) Sumihisa Orita et al.   BMC MUSCULOSKELETAL DISORDERS

Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts

(2011) Steeve Kwan Tat et al.   BONE

Morphea-like skin reactions in patients treated with the cathepsin K inhibitor balicatib

(2011) Thomas M. Rnger et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis

(2011) E. R. Sampson et al.   Science Translational Medicine

A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

(2011) Stanley B Cohen et al.   ARTHRITIS RESEARCH & THERAPY

OARSI recommendations for the management of hip and knee osteoarthritis: the semantics of differences and changes

(2010) T.E. McAlindon et al.   OSTEOARTHRITIS AND CARTILAGE

Treatment with TNF-α inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis

(2010) M. Güler-Yüksel et al.   OSTEOARTHRITIS AND CARTILAGE

OARSI recommendations for the management of hip and knee osteoarthritis

(2010) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Serum levels of vitamin D, sunlight exposure, and knee cartilage loss in older adults: The Tasmanian older adult cohort study

(2009) Changhai Ding et al.   ARTHRITIS AND RHEUMATISM

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

(2009) Mark E. Schnute et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants

(2009) Dorothea Piecha et al.   INFLAMMATION RESEARCH

Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study

(2009) Antonella Fioravanti et al.   RHEUMATOLOGY INTERNATIONAL

Cleavage of Type II Collagen by Cathepsin K in Human Osteoarthritic Cartilage

(2008) Valeria M. Dejica et al.   AMERICAN JOURNAL OF PATHOLOGY