Article
Psychiatry
Aras Neriman, Yilmaz Hakan, Ucuncu Ozge
Summary: The study suggests that vitamin D replacement therapy can improve symptoms in schizophrenia patients, especially positive and negative symptoms, and attention span. Regular monitoring of 25OHD levels, supplementation when necessary, and sunlight exposure are recommended for optimal outcomes.
Review
Nutrition & Dietetics
Manuel Rupprecht, Stefan Wagenpfeil, Jakob Schoepe, Reinhold Vieth, Thomas Vogt, Joerg Reichrath
Summary: A meta-analysis was conducted to investigate the impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in healthy adults in Europe. The findings suggest that vitamin D supplementation can significantly increase serum 25(OH)D levels, with the effect influenced by dosage and baseline serum levels.
Article
Public, Environmental & Occupational Health
Seyed Vahid Jasemi, Zhale Zandieh, Narges Zandieh, Mohsen Rezaei Hemami, Ali Darvishi, Zahra Abdollahi, Ramin Heshmat
Summary: This study aimed to assess the cost-effectiveness of the vitamin D supplementation program in reducing adolescent depressive symptoms in Iranian adolescents. The results showed that the program is a cost-effective and dominant strategy in preventing depression through cost-saving and QALYs increment.
Article
Biochemistry & Molecular Biology
Jie Chen, Jiao Zhang, Jie Li, Ran Qin, Na Lu, David Goltzman, Dengshun Miao, Renlei Yang
Summary: Emerging observational data suggest that vitamin D deficiency is associated with knee osteoarthritis. However, the relationship between vitamin D level and osteoarthritis, as well as the role of vitamin D supplementation in prevention, are still controversial. This study found that 1,25(OH)2D3 deficiency accelerated the development of knee osteoarthritis in mice, while supplementation with 1,25(OH)2D3 rescued the phenotypes of osteoarthritis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Food Science & Technology
Tuomas Mikola, Wolfgang Marx, Melissa M. Lane, Meghan Hockey, Amy Loughman, Sanna Rajapolvi, Tetyana Rocks, Adrienne O'Neil, David Mischoulon, Minna Valkonen-Korhonen, Soili M. Lehto, Anu Ruusunen
Summary: Neurosteroid and immunological actions of vitamin D may regulate depression-linked physiology. Meta-analysis results showed a positive effect of vitamin D on depressive symptoms, although the certainty was very low. Despite high heterogeneity, supplementation of vitamin D at a dose of ≥ 2,000 IU per day appears to reduce depressive symptoms. Future research should investigate the potential benefits of adjunctive vitamin D treatment in clinical depression.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Neurosciences
Gilciane Ceolin, Giulia Pipolo Rodrigues Mano, Natalia Schmitt Hames, Luciana da Conceicao Antunes, Elisa Brietzke, Debora Kurrle Rieger, Julia Dubois Moreira
Summary: Studies have shown that vitamin D deficiency is associated with mental health problems and individual responses to stress. Maintaining adequate concentrations of serum vitamin D seems to have a protective effect. Vitamin D regulates serotonergic neurotransmission, gene expression, and enzyme activity, while also potentially affecting the development of depressive symptoms through its interaction with the biological clock.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Angela Feiner Solis, Ana Avedillo Salas, Maria Jose Luesma Bartolome, Sonia Santander Ballestin
Summary: This systematic review examines the impact of vitamin D supplementation on the disease course of COVID-19. The results suggest that regardless of initial vitamin D serum levels, patients benefit from vitamin D supplementation, although the outcomes are inconsistent and larger clinical trials are needed for confirmation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Clinical
Gengfu Wang, Mengyuan Yuan, Junjie Chang, Yonghan Li, Robert Blum, Puyu Su
Summary: This study found an association between baseline vitamin D levels and depression risk in early adolescents, with higher vitamin D levels linked to lower depression risk. A male-specific association between vitamin D and depression risk was also observed. These findings suggest a potential beneficial effect of vitamin D supplementation in reducing depression risk in early adolescents.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Christian Mingiano, Tommaso Picchioni, Guido Cavati, Filippo Pirrotta, Marco Calabrese, Ranuccio Nuti, Stefano Gonnelli, Alberto Fortini, Bruno Frediani, Luigi Gennari, Daniela Merlotti
Summary: This study aimed to evaluate the relationship between 25-OH vitamin D (25OHD) levels and prognosis, mortality, mechanical ventilation, and orotracheal intubation in hospitalized COVID-19 patients. The study found a positive correlation between 25OHD levels and oxygenation levels, and significantly lower levels in patients requiring mechanical ventilation and intubation. Patients with severe 25OHD deficiency had longer hospital stays and higher mortality rates. Additionally, supplementation with calcifediol reduced hospitalization duration and mortality rates.
Article
Nutrition & Dietetics
Myeongseob Lee, Hae In Lee, Kyungchul Song, Han Saem Choi, Junghwan Suh, Se Hee Kim, Hyun Wook Chae, Hoon-Chul Kang, Joon Soo Lee, Heung Dong Kim, Ho-Seong Kim, Ahreum Kwon
Summary: This study aimed to evaluate the dose-dependent association between vitamin D-3 and hypercalciuria/urolithiasis in patients undergoing KDT and dose optimization for renal complications.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Rosalyn J. Singleton, Gretchen M. Day, Timothy K. Thomas, Joseph A. Klejka, Christine A. Desnoyers, Melanie N. P. McIntyre, David M. Compton, Kenneth E. Thummel, Robert J. Schroth, Leanne M. Ward, Dane C. Lenaker, Rachel K. Lescher, Joseph B. McLaughlin
Summary: The study found that prenatal vitamin D supplementation in high-risk populations can improve childhood outcomes regarding rickets and dental caries.
Article
Neurosciences
Faezeh Kazemi, Shirin Babri, Parisa Keyhanmehr, Mahsa Farid-Habibi, Sepehr Nayebi Rad, Fereshteh Farajdokht
Summary: Gestational or developmental vitamin D deficiency has long-term effects on brain development and neurobehavioral disorders in offspring. Supplementing vitamin D and engaging in physical exercise are reasonable strategies to prevent these impairments.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Nutrition & Dietetics
Monia Kittana, Asma Ahmadani, Lily Stojanovska, Amita Attlee
Summary: Children with autism spectrum disorder (ASD) have lower vitamin D levels and the deficiency is strongly correlated with ASD severity. Vitamin D supplementation can significantly reduce ASD severity, but the effect may vary between treatment and control groups. Variations in vitamin D dose protocols and concurrent interventions may contribute to the variability of results. The age of introducing vitamin D intervention may also affect the effectiveness of treatment. Further long-term, well-designed randomized controlled trials are needed to confirm the impact of vitamin D on severity in children with ASD.
Article
Nutrition & Dietetics
Fanny Loddo, Steve Nauleau, David Lapalus, Sophie Tardieu, Olivier Bernard, Farid Boubred
Summary: This population-based record-linkage study examined the association between maternal gestational Vitamin D3 supplementation and early respiratory health in offspring. The study found that infants prenatally exposed to maternal Vitamin D3 supplementation had a longer gestational age at birth and a lower risk of respiratory illness. This study provides evidence for the positive impact of maternal gestational Vitamin D3 supplementation on early respiratory outcomes in young children.
Review
Nutrition & Dietetics
Mohammed M. Hassanein, Hasniza Zaman Huri, Kauser Baig, Abduelmula R. Abduelkarem
Summary: Hormonal fluctuations, excessive clothing covering, sunscreen use, changes in body fat composition, a vitamin D-deficient diet, and a sedentary lifestyle can all predispose postmenopausal women to vitamin D deficiency. An effective supplementation plan requires a thorough understanding of underlying factors to achieve the desired therapeutic concentrations. This study conducted a systematic review to identify predictors that affect vitamin D status in postmenopausal women.
Article
Rheumatology
Zetao Liao, Jun Chang, Zhaohua Zhu, Weiyu Han, Tao Meng, Shuang Zheng, Liudan Tu, Benny Antony, Tania Winzenberg, Anita E. Wluka, Flavia Cicuttini, Changhai Ding
Summary: The study examined the associations between dietary vitamin K intake and changes in knee symptoms and structures in patients with knee osteoarthritis (OA). The results showed that higher vitamin K intake was associated with a decrease in knee symptoms over 24 months. However, there was no overall association between vitamin K intake and changes in MRI features.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Orthopedics
T. Lin, S. Peng, S. Lu, S. Fu, D. Zeng, J. Li, T. Chen, T. Fan, C. Lang, S. Feng, J. Ma, C. Zhao, B. Antony, F. Cicuttini, X. Quan, Z. Zhu, C. Ding
Summary: A diagnostic nomogram integrating MRI radiomics signature of subchondral bone and clinical characteristics has been developed to detect improved knee pain in osteoarthritis (OA). The nomogram showed favorable discrimination performance and good calibration. This proof-of-concept study provides a promising way to predict clinically meaningful outcomes.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Rheumatology
Delong Li, Guangfeng Ruan, Yan Zhang, Yang Zhao, Zhaohua Zhu, Qianhua Ou, Hong Huang, Jieli Chen, Weiyu Han, Su'an Tang, Jia Li, Liang Wang, Tianyu Chen, Xiaochun Bai, Daozhang Cai, Changhai Ding
Summary: This study investigated the therapeutic effect and mechanism of metformin on knee osteoarthritis (OA). The results showed that metformin had a protective effect by reducing apoptosis and catabolism of chondrocytes, suppressing infiltration and pro-inflammatory polarization of synovial macrophages, and reducing leptin secretion from adipose tissue in obese mice.
Article
Rheumatology
S. J. J. Drummen, S. Balogun, A. Lahham, K. Bennell, R. S. Hinman, M. Callisaya, G. Cai, P. Otahal, T. Winzenberg, Z. Wang, B. Antony, I. P. Munugoda, J. Martel-Pelletier, J. P. Pelletier, F. Abram, G. Jones, D. Aitken
Summary: This study aimed to determine the feasibility of a randomized controlled trial (RCT) examining the effects of outdoor walking on knee osteoarthritis (KOA) clinical outcomes and MRI structural changes. The study found that a full-scale RCT is feasible based on acceptable adherence, retention, randomization, and safety, although recruitment challenges were identified. The significant symptomatic benefits demonstrate the clinical usefulness of a subsequent trial.
CLINICAL RHEUMATOLOGY
(2023)
Article
Plant Sciences
Zhiqiang Wang, Tania Winzenberg, Ambrish Singh, Dawn Aitken, Leigh Blizzard, Mikael Boesen, Edwin H. G. Oei, Tijmen A. van Zadelhoff, Venkat Parameswaran, Changhai Ding, Robert Jones, Benny Antony
Summary: This study aimed to investigate the effects of Curcuma longa (CL) extract on serum inflammatory markers and synovitis in knee osteoarthritis patients. The results showed that CL treatment did not have significant effects on systemic and local synovitis, and the mechanism of action for pain relief remains unclear.
Article
Rheumatology
Hylton B. B. Menz, Jamie J. J. Allan, Andrew K. K. Buldt, Karl B. B. Landorf, Flavia M. M. Cicuttini, Edward Roddy, Shannon E. E. Munteanu
Summary: This study aimed to determine whether neuropathic pain is a feature of first metatarsophalangeal (MTP) joint osteoarthritis (OA). By comparing pain questionnaire results and related factors, the study found that a significant proportion of individuals with first MTP joint OA experience neuropathic pain, which may partly explain the suboptimal responses to commonly used treatments. Screening for neuropathic pain may be useful in selecting targeted interventions and improving clinical outcomes.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Medicine, General & Internal
Nicholas Woodland, Antony Takla, Mahnuma Mahfuz Estee, Angus Franks, Mansi Bhurani, Susan Liew, Flavia M. Cicuttini, Yuanyuan Wang
Summary: This systematic review evaluated the patient-reported outcomes following total knee replacement in individuals aged 65 years and older. The study found that TKR can reduce pain, improve function, and increase the quality of life for older individuals. Patients generally reported overall satisfaction with the results of the surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Xiaorui Shi, Yiying Mai, Xiaofeng Fang, Zhiqiang Wang, Song Xue, Haowei Chen, Qin Dang, Xiaoshuai Wang, Su'an Tang, Changhai Ding, Zhaohua Zhu
Summary: Bone marrow lesions (BMLs), prevalent and important MRI features in osteoarthritis (OA) patients, occur earlier than cartilage degeneration. The exact roles of BMLs in OA pathogenesis, as well as the clinical impact and treatment, are still unclear. This review summarizes the current progress in basic and clinical research on BMLs, focusing on molecular pathways, cellular abnormalities, and the interplay between subchondral bone and cartilage in OA development. Potential therapeutic strategies targeting BMLs in OA are also discussed, providing novel approaches for OA treatment.
Article
Rheumatology
Yan Zhang, Jingyu Xie, Simin Wen, Peihua Cao, Wende Xiao, Jianwei Zhu, Shengfa Li, Zhiqiang Wang, Han Cen, Zhaohua Zhu, Changhai Ding, Guangfeng Ruan
Summary: This study conducted large-scale two-sample Mendelian randomisation analyses to identify circulating proteins that are causally associated with osteoarthritis (OA)-related traits. Multiple additional analyses were performed to validate the findings and investigate potential therapeutic targets for OA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Zhiqiang Wang, Graeme Jones, Leigh Blizzard, Dawn Aitken, Zhen Zhou, Mengmeng Wang, Saliu Balogun, Flavia Cicuttini, Benny Antony
Summary: This study aimed to describe the prevalence and correlates of the use of complementary and alternative medicines (CAMs) among community-dwelling older adults. The results showed that 35% of the participants reported CAM use, with vitamins/minerals being the most commonly used. CAM users were more likely to be female, be better educated, have more joints with osteoarthritis, and have healthier lifestyles.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Meeting Abstract
Medicine, General & Internal
Jacinta Cheng, Flavia Cicuttini, Graeme Jones, Helen Keen, Catherine Hill, Anita Wluka, Andrew Teichtahl, Benny Antony, Yuanyuan Wang
INTERNAL MEDICINE JOURNAL
(2023)
Meeting Abstract
Medicine, General & Internal
Jason Rogers, Graeme Jones, Jill Cook, Kathryn Squibb, Andrew Halliday, Aroub Lahham, Tania Winzenberg
INTERNAL MEDICINE JOURNAL
(2023)
Review
Rheumatology
Anran Xuan, Haowei Chen, Tianyu Chen, Jia Li, Shilong Lu, Tianxiang Fan, Dong Zeng, Zhibo Wen, Jianhua Ma, David Hunter, Changhai Ding, Zhaohua Zhu
Summary: Osteoarthritis (OA) is a prevalent musculoskeletal disease worldwide, leading to joint pain, disability, decreased quality of life, and a significant burden on healthcare services. However, current diagnostic methods are not suitable for early diagnosis of OA. The use of machine learning (ML) in OA diagnosis has grown in recent years. This review article discusses the progress, trends, limitations, and future research priorities of ML in early OA diagnosis. Accurate ML-based predictive models with imaging techniques that detect early changes in OA are expected to overcome the current diagnostic challenges.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Letter
Clinical Neurology
J. Tian, G. Jones, X. Lin, Y. Zhou, A. King, J. Vickers, Feng Pan
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)