The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

Cathepsin K inhibitors and antisclerostin antibodies. The next treatments for osteoporosis?

(2016) Roland Chapurlat   JOINT BONE SPINE

Data gaps limit the translational potential of preclinical research

(2016) Robin J. Kleiman et al.   Science Translational Medicine

Three-Dimensional Quantitative Morphometric Analysis (QMA) for In Situ Joint and Tissue Assessment of Osteoarthritis in a Preclinical Rabbit Disease Model

(2016) Kathryn S. Stok et al.   PLoS One

Subchondral bone and osteoarthritis

(2015) Thomas Funck-Brentano et al.   CURRENT OPINION IN RHEUMATOLOGY

Effect of Age-Related Cartilage Turnover on Serum C-Telopeptide of Collagen Type II and Osteocalcin Levels in Growing Rabbits with and without Surgically Induced Osteoarthritis

(2014) Chung-Cheng Huang et al.   Biomed Research International

Alpha C-Telopeptide of Type I Collagen Is Associated With Subchondral Bone Turnover and Predicts Progression of Joint Space Narrowing and Osteophytes in Osteoarthritis

(2014) Janet L. Huebner et al.   Arthritis & Rheumatology

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind randomised, placebo-controlled trial

(2013) J-Y Reginster   ANNALS OF THE RHEUMATIC DISEASES

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

(2013) M A Karsdal et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoporotic OA: a reasonable target for bone-acting agents

(2013) Gabriel Herrero-Beaumont et al.   Nature Reviews Rheumatology

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

(2012) Tadashi Hayami et al.   BONE

Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis

(2012) Steven R. Goldring   Therapeutic Advances in Musculoskeletal Disease

Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: The OCEAN study

(2011) Richard Eastell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys

(2011) Patricia J Masarachia et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Subchondral bone changes in three different canine models of osteoarthritis

(2011) K. Kuroki et al.   OSTEOARTHRITIS AND CARTILAGE

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys

(2011) C. Jerome et al.   OSTEOPOROSIS INTERNATIONAL

Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: Confirmation by multivariate analysis that modulation of type ii collagen and aggrecan degradation pepti

(2010) Steven Settle et al.   ARTHRITIS AND RHEUMATISM

Similarities and discrepancies in subchondral bone structure in two differently induced canine models of osteoarthritis

(2010) Femke Intema et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits

(2010) Brenda L Pennypacker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect

(2010) John A Eisman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study

(2009) T. Neogi et al.   ANNALS OF THE RHEUMATIC DISEASES

Cartilage loss occurs in the same subregions as subchondral bone attrition: A within-knee subregion-matched approach from the multicenter osteoarthritis study

(2009) T. Neogi et al.   ARTHRITIS AND RHEUMATISM

Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis

(2009) J.R. Connor et al.   OSTEOARTHRITIS AND CARTILAGE

Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study

(2009) F.W. Roemer et al.   OSTEOARTHRITIS AND CARTILAGE

Cleavage of Type II Collagen by Cathepsin K in Human Osteoarthritic Cartilage

(2008) Valeria M. Dejica et al.   AMERICAN JOURNAL OF PATHOLOGY

A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models

(2008) Yvonne H Sniekers et al.   BMC MUSCULOSKELETAL DISORDERS