Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β

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(2014) S.X. Wang et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-1 dual variable domain immunoglobulin, a new potential treatment for osteoarthritis

(2014) S.X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis

(2011) Mukundan Attur et al.   ARTHRITIS AND RHEUMATISM

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

126 SIMULTANEOUS TARGETING OF IL-1A AND IL-1B BY A DUAL-VARIABLE-DOMAIN IMMUNOGLOBULIN (DVD-IG(tm)) PREVENTS CARTILAGE DEGRADATION IN PRECLINICAL MODELS OF OSTEOARTHRITIS

(2011) R.V. Kamath et al.   OSTEOARTHRITIS AND CARTILAGE

A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

(2011) Stanley B Cohen et al.   ARTHRITIS RESEARCH & THERAPY

Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-IgTM) molecules

(2010) Chengbin Wu et al.   mAbs

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

An improved yeast transformation method for the generation of very large human antibody libraries

(2010) Lorenzo Benatuil et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

Review: Immune cells and mediators of inflammatory arthritis

(2008) Georg Schett   AUTOIMMUNITY

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION

Correlation of gene and mediator expression with clinical endpoints in an acute interleukin-1β-driven model of joint pathology

(2008) I. Scott et al.   OSTEOARTHRITIS AND CARTILAGE