The Interplay of HIV-1 and Macrophages in Viral Persistence

A minor population of macrophage-tropic HIV-1 variants is identified in recrudescing viremia following analytic treatment interruption

(2020) Viviane M. Andrade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

(2019) Yonatan Ganor et al.   Nature Microbiology

Contribution of the cytoplasmic determinants of Vpu to the expansion of virus containing compartments in HIV-1 infected macrophages

(2019) Olivier Leymarie et al.   JOURNAL OF VIROLOGY

Characterization of intact proviruses in blood and lymph node from HIV-infected individuals undergoing analytical treatment interruption

(2019) Line K. Vibholm et al.   JOURNAL OF VIROLOGY

HIV “shock and kill” therapy: In need of revision

(2019) Erik Abner et al.   ANTIVIRAL RESEARCH

Different Patterns of HIV-1 Replication in MACROPHAGES is Led by Co-Receptor Usage

(2019) Borrajo et al.   Medicina-Lithuania

Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques

(2019) Celina M. Abreu et al.   mBio

TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function

(2019) Grant R. Campbell et al.   mBio

The Role of Macrophages in HIV-1 Persistence and Pathogenesis

(2019) Zita Kruize et al.   Frontiers in Microbiology

Novel Latency Reversal Agents for HIV-1 Cure

(2018) Adam M. Spivak et al.   Annual Review of Medicine

Resistance of HIV-infected macrophages to CD8+ T lymphocyte–mediated killing drives activation of the immune system

(2018) Kiera L. Clayton et al.   NATURE IMMUNOLOGY

Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents

(2018) Vipul Gupta et al.   PLoS Computational Biology

Reversible Human Immunodeficiency Virus Type-1 Latency in Primary Human Monocyte-Derived Macrophages Induced by Sustained M1 Polarization

(2018) Francesca Graziano et al.   Scientific Reports

Nonhuman Primate Models and Understanding the Pathogenesis of HIV Infection and AIDS

(2017) Ronald S Veazey et al.   ILAR JOURNAL

Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

(2017) Nancie M. Archin et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages

(2017) Najla Nasr et al.   JOURNAL OF VIROLOGY

CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses

(2017) Benjamin Descours et al.   NATURE

HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy

(2017) Jenna B Honeycutt et al.   NATURE MEDICINE

Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness

(2017) Shilpa S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy

(2017) Mariluz Araínga et al.   Retrovirology

Role of CD8+ T Cells in the Selection of HIV-1 Immune Escape Mutations

(2017) David Arcia et al.   VIRAL IMMUNOLOGY

A humanized mouse-based HIV-1 viral outgrowth assay with higher sensitivity than in vitro qVOA in detecting latently infected cells from individuals on ART with undetectable viral loads

(2017) Paige Charlins et al.   VIROLOGY

Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir

(2017) Claudia R. Avalos et al.   mBio

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

Humanized mouse models of latent HIV infection

(2017) Maud Deruaz et al.   Current Opinion in Virology

Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1

(2017) Jason E. Hammonds et al.   PLoS Pathogens

HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim

(2017) Paul Castellano et al.   Scientific Reports

Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction

(2016) Toshana L. Foster et al.   Cell Host & Microbe

ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions

(2016) Rikke Olesen et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages sustain HIV replication in vivo independently of T cells

(2016) Jenna B. Honeycutt et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques

(2016) Claudia R. Avalos et al.   JOURNAL OF VIROLOGY

Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo

(2016) Adam M. Spivak et al.   Retrovirology

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

(2016) E. L. Soucie et al.   SCIENCE

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

Strategies to target HIV-1 in the central nervous system

(2016) Lachlan R. Gray et al.   Current Opinion in HIV and AIDS

Targeting the Brain Reservoirs: Toward an HIV Cure

(2016) Céline Marban et al.   Frontiers in Immunology

HIV-1 cellular and tissue replication patterns in infected humanized mice

(2016) Mariluz Araínga et al.   Scientific Reports

Healthy HIV-1-Infected Individuals on Highly Active Antiretroviral Therapy Harbor HIV-1 in Their Alveolar Macrophages

(2015) Sushma K. Cribbs et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Macrophage polarization in pathology

(2015) Antonio Sica et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads

(2015) Kelly A. Metcalf Pate et al.   JOURNAL OF INFECTIOUS DISEASES

HIV Blocks Interferon Induction in Human Dendritic Cells and Macrophages by Dysregulation of TBK1

(2015) Andrew N. Harman et al.   JOURNAL OF VIROLOGY

Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+T Cell Killing

(2015) Jennifer N. Rainho et al.   JOURNAL OF VIROLOGY

CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies

(2015) L R Gray et al.   MOLECULAR PSYCHIATRY

The local environment orchestrates mucosal decidual macrophage differentiation and substantially inhibits HIV-1 replication

(2015) H El Costa et al.   Mucosal Immunology

HIV reservoirs: what, where and how to target them

(2015) Melissa J. Churchill et al.   NATURE REVIEWS MICROBIOLOGY

SIV Infection of Lung Macrophages

(2015) Yue Li et al.   PLoS One

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

(2015) Guochun Jiang et al.   PLoS Pathogens

Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing

(2014) Nadine Laguette et al.   CELL

Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells

(2014) Amy E. Baxter et al.   Cell Host & Microbe

Tissue Myeloid Cells in SIV-Infected Primates Acquire Viral DNA through Phagocytosis of Infected T Cells

(2014) Nina Calantone et al.   IMMUNITY

Mononuclear phagocytes of the intestine, the skin, and the lung

(2014) Charlotte L. Scott et al.   IMMUNOLOGICAL REVIEWS

Autophagy Induction by Histone Deacetylase Inhibitors Inhibits HIV Type 1

(2014) Grant R. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat

(2014) N. M. Archin et al.   JOURNAL OF INFECTIOUS DISEASES

Comparative Analysis of the Capacity of Elite Suppressor CD4+ and CD8+ T Cells To Inhibit HIV-1 Replication in Monocyte-Derived Macrophages

(2014) V. E. K. Walker-Sperling et al.   JOURNAL OF VIROLOGY

Small alveolar macrophages are infected preferentially by HIV and exhibit impaired phagocytic function

(2014) K C Jambo et al.   Mucosal Immunology

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Eradicating HIV-1 infection: seeking to clear a persistent pathogen

(2014) Nancie M. Archin et al.   NATURE REVIEWS MICROBIOLOGY

Dual Role of Novel Ingenol Derivatives from Euphorbia tirucalli in HIV Replication: Inhibition of De Novo Infection and Activation of Viral LTR

(2014) Celina M. Abreu et al.   PLoS One

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

(2014) Courtney V. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Accessory Proteins Adapt Cellular Adaptors to Facilitate Immune Evasion

(2014) David R. Collins et al.   PLoS Pathogens

DNA damage repair machinery and HIV escape from innate immune sensing

(2014) Christelle Brégnard et al.   Frontiers in Microbiology

M1 polarization of human monocyte-derived macrophages restricts pre and postintegration steps of HIV-1 replication

(2013) Luca Cassetta et al.   AIDS

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Comprehensive Assessment of HIV Target Cells in the Distal Human Gut Suggests Increasing HIV Susceptibility Toward the Anus

(2013) M. J. McElrath et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

The Distribution of HIV DNA and RNA in Cell Subsets Differs in Gut and Blood of HIV-Positive Patients on ART: Implications for Viral Persistence

(2013) Steven A. Yukl et al.   JOURNAL OF INFECTIOUS DISEASES

Targeting I B Proteins for HIV Latency Activation: the Role of Individual I B and NF- B Proteins

(2013) G. Fernandez et al.   JOURNAL OF VIROLOGY

Quantification of Entry Phenotypes of Macrophage-Tropic HIV-1 across a Wide Range of CD4 Densities

(2013) S. B. Joseph et al.   JOURNAL OF VIROLOGY

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

Observation of theHeΛ7Hypernucleus by the (e,e′K+) Reaction

(2013) S. N. Nakamura et al.   PHYSICAL REVIEW LETTERS

Dynamics of HIV-Containing Compartments in Macrophages Reveal Sequestration of Virions and Transient Surface Connections

(2013) Raphaël Gaudin et al.   PLoS One

Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

(2013) P. A. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T cell-only mouse (TOM) model

(2013) Jenna B Honeycutt et al.   Retrovirology

Combined approaches for HIV cure

(2013) David M. Margolis et al.   Current Opinion in HIV and AIDS

Comparison of HDAC inhibitors in clinical development

(2013) Thomas Aagaard Rasmussen et al.   Human Vaccines & Immunotherapeutics

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Macrophage polarization and plasticity in health and disease

(2012) Subhra K. Biswas et al.   IMMUNOLOGIC RESEARCH

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Mucosal Tissue Tropism and Dissemination of HIV-1 Subtype B Acute Envelope-Expressing Chimeric Virus

(2012) D. F. L. King et al.   JOURNAL OF VIROLOGY

HIV-1 Induces Telomerase Activity in Monocyte-Derived Macrophages, Possibly Safeguarding One of Its Reservoirs

(2012) R. Reynoso et al.   JOURNAL OF VIROLOGY

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Shock and kill

(2012) Steven G. Deeks   NATURE

Macrophages and their relevance in Human Immunodeficiency Virus Type I infection

(2012) Herwig Koppensteiner et al.   Retrovirology

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons

(2012) Viviana Cobos Jiménez et al.   Scientific Reports

Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection

(2011) Yi Liu et al.   PLoS One

Macrophage Polarization in Health and Disease

(2011) Luca Cassetta et al.   TheScientificWorldJOURNAL

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

(2010) Matthew B. Lanktree et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART

(2010) Alberto Zalar et al.   ANTIVIRAL RESEARCH

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

(2010) Michael A. Brehm et al.   CLINICAL IMMUNOLOGY

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

M1 and M2a Polarization of Human Monocyte-Derived Macrophages Inhibits HIV-1 Replication by Distinct Mechanisms

(2009) Edana Cassol et al.   JOURNAL OF IMMUNOLOGY

Microarray Analysis of Lymphatic Tissue Reveals Stage-Specific, Gene Expression Signatures in HIV-1 Infection

(2009) Q. Li et al.   JOURNAL OF IMMUNOLOGY

Macrophage polarization and HIV-1 infection

(2009) Edana Cassol et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

(2009) Mayte Coiras et al.   NATURE REVIEWS MICROBIOLOGY

Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice

(2009) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA