Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents

Proliferation of latently infected CD4+T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

(2017) Nina N. Hosmane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proviral Latency, Persistent Human Immunodeficiency Virus Infection, and the Development of Latency Reversing Agents

(2017) David M. Margolis et al.   JOURNAL OF INFECTIOUS DISEASES

Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy

(2016) Carolina Gutiérrez et al.   AIDS

The mTOR Complex Controls HIV Latency

(2016) Emilie Besnard et al.   Cell Host & Microbe

International AIDS Society global scientific strategy: towards an HIV cure 2016

(2016) Steven G Deeks et al.   NATURE MEDICINE

Position effects influence HIV latency reversal

(2016) Heng-Chang Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Latency reversal and viral clearance to cure HIV-1

(2016) D. M. Margolis et al.   SCIENCE

Reversal of Latency as Part of a Cure for HIV-1

(2016) Thomas Aagaard Rasmussen et al.   TRENDS IN MICROBIOLOGY

Position effects influence HIV latency reversal

(2016) Heng-Chang Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV

(2016) Alison L. Hill et al.   PLoS Pathogens

Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents

(2016) Héloïse M. Delagrèverie et al.   Open Forum Infectious Diseases

Euphorbia Kansui Reactivates Latent HIV

(2016) Daniele C. Cary et al.   PLoS One

Targeting NF-κB Signaling with Protein Kinase C Agonists As an Emerging Strategy for Combating HIV Latency

(2015) Guochun Jiang et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

I Am the Berlin Patient: A Personal Reflection

(2015) Timothy Ray Brown   AIDS RESEARCH AND HUMAN RETROVIRUSES

A Hardwired HIV Latency Program

(2015) Brandon S. Razooky et al.   CELL

An Evolutionary Role for HIV Latency in Enhancing Viral Transmission

(2015) Igor M. Rouzine et al.   CELL

Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1

(2015) S. Bouchat et al.   EMBO Molecular Medicine

Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

(2015) Gregory M. Laird et al.   JOURNAL OF CLINICAL INVESTIGATION

Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child

(2015) Katherine Luzuriaga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Post-treatment control of HIV infection

(2015) Jessica M. Conway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct promoter activation mechanisms modulate noise-driven HIV gene expression

(2015) Arvind K. Chavali et al.   Scientific Reports

Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1

(2015) Marta Martínez-Bonet et al.   Scientific Reports

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days—Implications for HIV Remission

(2015) Mykola Pinkevych et al.   PLoS Pathogens

Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

(2015) Guochun Jiang et al.   PLoS Pathogens

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

(2015) Ole S. Søgaard et al.   PLoS Pathogens

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study

(2015) Julian H Elliott et al.   Lancet HIV

Quantitative Evaluation and Optimization of Co-drugging to Improve Anti-HIV Latency Therapy

(2014) Victor C. Wong et al.   Cellular and Molecular Bioengineering

Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys

(2014) James B. Whitney et al.   NATURE

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Eradicating HIV-1 infection: seeking to clear a persistent pathogen

(2014) Nancie M. Archin et al.   NATURE REVIEWS MICROBIOLOGY

Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

(2014) A. R. Cillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1

(2014) Alison L. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screening for noise in gene expression identifies drug synergies

(2014) R. D. Dar et al.   SCIENCE

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

An Integrated Overview of HIV-1 Latency

(2013) Debbie S. Ruelas et al.   CELL

Histone Deacetylase Inhibitors (HDACis) That Release the Positive Transcription Elongation Factor b (P-TEFb) from Its Inhibitory Complex Also Activate HIV Transcription

(2013) Koen Bartholomeeusen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 transcription and latency: an update

(2013) Carine Van Lint et al.   Retrovirology

Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression

(2013) J. Karn et al.   Cold Spring Harbor Perspectives in Medicine

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

(2013) Celsa A. Spina et al.   PLoS Pathogens

Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study

(2013) Asier Sáez-Cirión et al.   PLoS Pathogens

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

StochKit2: software for discrete stochastic simulation of biochemical systems with events

(2011) K. R. Sanft et al.   BIOINFORMATICS

Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65

(2011) Giuseppe Fiume et al.   NUCLEIC ACIDS RESEARCH

Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule

(2011) L. Josefsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteome Half-Life Dynamics in Living Human Cells

(2011) E. Eden et al.   SCIENCE

A Stochastic Model of Latently Infected Cell Reactivation and Viral Blip Generation in Treated HIV Patients

(2011) Jessica M. Conway et al.   PLoS Computational Biology

Bryostatin-1 Synergizes with Histone Deacetylase Inhibitors to Reactivate HIV-1 from Latency

(2010) Moises Perez et al.   CURRENT HIV RESEARCH

Combinatorial Latency Reactivation for HIV-1 Subtypes and Variants

(2010) J. C. Burnett et al.   JOURNAL OF VIROLOGY

HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP

(2010) Bijan Sobhian et al.   MOLECULAR CELL

Intracellular transactivation of HIV can account for the decelerating decay of virus load during drug therapy

(2010) Christian L Althaus et al.   Molecular Systems Biology

Histone deacetylase inhibitors and HIV latency

(2010) David M Margolis   Current Opinion in HIV and AIDS

Structural Basis of HIV-1 Activation by NF-κB—A Higher-Order Complex of p50:RelA Bound to the HIV-1 LTR

(2009) James C. Stroud et al.   JOURNAL OF MOLECULAR BIOLOGY

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

HIV rebounds from latently infected cells, rather than from continuing low-level replication

(2008) B. Joos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA