Nonhuman Primate Models and Understanding the Pathogenesis of HIV Infection and AIDS

Whole genome sequencing predicts novel human disease models in rhesus macaques

(2017) Benjamin N. Bimber et al.   GENOMICS

Comparison of the Canadian and US Laws, Regulations, Policies, and Systems of Oversight for Animals in Research

(2017) Gilly Griffin et al.   ILAR JOURNAL

Tackling HIV and AIDS: contributions by non-human primate models

(2017) Koen K A Van Rompay   LAB ANIMAL

A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif

(2017) Yusuke Nakano et al.   Retrovirology

Th17 Cells Are Preferentially Infected Very Early after Vaginal Transmission of SIV in Macaques

(2016) Daniel J. Stieh et al.   Cell Host & Microbe

HIV-1 Vpu Mediates HLA-C Downregulation

(2016) Richard Apps et al.   Cell Host & Microbe

New concepts in HIV-1 vaccine development

(2016) Kathryn E Stephenson et al.   CURRENT OPINION IN IMMUNOLOGY

CXCR6-Mediated Simian Immunodeficiency Virus SIVagmSab Entry into Sabaeus African Green Monkey Lymphocytes Implicates Widespread Use of Non-CCR5 Pathways in Natural Host Infections

(2016) Katherine S. Wetzel et al.   JOURNAL OF VIROLOGY

Discovery of unfixed endogenous retrovirus insertions in diverse human populations

(2016) Julia Halo Wildschutte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

(2016) P. Abbink et al.   SCIENCE

Sustained virologic control in SIV+ macaques after antiretroviral and  4 7 antibody therapy

(2016) S. N. Byrareddy et al.   SCIENCE

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells

(2015) Bin Xia Yang et al.   CELL

Distinct Compartmentalization in the CNS of SHIVKU-1-Infected Chinese Rhesus Macaque Is Associated With Severe Neuropathology

(2015) Qianhao Xiao et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Persistent Simian Immunodeficiency Virus Infection Causes Ultimate Depletion of Follicular Th Cells in AIDS

(2015) Huanbin Xu et al.   JOURNAL OF IMMUNOLOGY

Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif

(2015) Matthew W. Breed et al.   JOURNAL OF VIROLOGY

Persistent Simian Immunodeficiency Virus Infection Drives Differentiation, Aberrant Accumulation, and Latent Infection of Germinal Center Follicular T Helper Cells

(2015) Huanbin Xu et al.   JOURNAL OF VIROLOGY

Reduced Simian Immunodeficiency Virus Replication in Macrophages of Sooty Mangabeys Is Associated with Increased Expression of Host Restriction Factors

(2015) Kiran D. Mir et al.   JOURNAL OF VIROLOGY

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

(2015) Yoshinori Fukazawa et al.   NATURE MEDICINE

Origin of the HIV-1 group O epidemic in western lowland gorillas

(2015) Mirela D’arc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain

(2015) A. Marzi et al.   SCIENCE

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

(2015) D. H. Barouch et al.   SCIENCE

Antibodies for prevention of mother-to-child transmission of HIV-1

(2015) Genevieve G. Fouda et al.   Current Opinion in HIV and AIDS

Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral Infections

(2015) Edward J. D. Greenwood et al.   PLoS Pathogens

Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques

(2015) Félicien Moukambi et al.   PLoS Pathogens

Why primate models matter

(2014) Kimberley A. Phillips et al.   AMERICAN JOURNAL OF PRIMATOLOGY

Diminished Viral Control during Simian Immunodeficiency Virus Infection Is Associated with Aberrant PD-1hiCD4 T Cell Enrichment in the Lymphoid Follicles of the Rectal Mucosa

(2014) Geetha H. Mylvaganam et al.   JOURNAL OF IMMUNOLOGY

Profound loss of intestinal Tregs in acutely SIV-infected neonatal macaques

(2014) Xiaolei Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Recombinant adenovirus type 5 HIV gag/pol/nef vaccine in South Africa: unblinded, long-term follow-up of the phase 2b HVTN 503/Phambili study

(2014) Glenda E Gray et al.   LANCET INFECTIOUS DISEASES

Retroviral Transcriptional Regulation and Embryonic Stem Cells: War and Peace

(2014) Sharon Schlesinger et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys

(2014) James B. Whitney et al.   NATURE

The dysfunction of T follicular helper cells

(2014) Rafael Cubas et al.   Current Opinion in HIV and AIDS

PD-1HIGH Follicular CD4 T Helper Cell Subsets Residing in Lymph Node Germinal Centers Correlate with B Cell Maturation and IgG Production in Rhesus Macaques

(2014) Huanbin Xu et al.   Frontiers in Immunology

IACUC Review of Nonhuman Primate Research

(2013) S. D. Tardif et al.   ILAR JOURNAL

Systemic Effects of Inflammation on Health during Chronic HIV Infection

(2013) Steven G. Deeks et al.   IMMUNITY

Divergent Kinetics of Proliferating T Cell Subsets in Simian Immunodeficiency Virus (SIV) Infection: SIV Eliminates the "First Responder" CD4+ T Cells in Primary Infection

(2013) X. Wang et al.   JOURNAL OF VIROLOGY

Immune clearance of highly pathogenic SIV infection

(2013) Scott G. Hansen et al.   NATURE

Phenotypic properties of transmitted founder HIV-1

(2013) N. F. Parrish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HIV-1 pandemic: does the selective sweep in chimpanzees mirror humankind’s future?

(2013) Natasja G de Groot et al.   Retrovirology

Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms

(2013) S. G. Hansen et al.   SCIENCE

New directions for HIV vaccine development from animal models

(2013) Michael B. McChesney et al.   Current Opinion in HIV and AIDS

Origins of HIV and the AIDS Pandemic

(2013) P. M. Sharp et al.   Cold Spring Harbor Perspectives in Medicine

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

SIVagm Infection in Wild African Green Monkeys from South Africa: Epidemiology, Natural History, and Evolutionary Considerations

(2013) Dongzhu Ma et al.   PLoS Pathogens

CD4+FOXP3+ Regulatory T-Cell Subsets in Human Immunodeficiency Virus Infection

(2013) Federico Simonetta et al.   Frontiers in Immunology

Preexposure prophylaxis for the prevention of HIV transmission to women

(2012) Erika Aaron et al.   AIDS

Mucosal Simian Immunodeficiency Virus Transmission in African Green Monkeys: Susceptibility to Infection Is Proportional to Target Cell Availability at Mucosal Sites

(2012) Ivona Pandrea et al.   JOURNAL OF VIROLOGY

Transmitted/Founder and Chronic HIV-1 Envelope Proteins Are Distinguished by Differential Utilization of CCR5

(2012) Z. F. Parker et al.   JOURNAL OF VIROLOGY

Risk of Immunodeficiency Virus Infection May Increase with Vaccine-Induced Immune Response

(2012) M. Tenbusch et al.   JOURNAL OF VIROLOGY

Animal models for HIV/AIDS research

(2012) Theodora Hatziioannou et al.   NATURE REVIEWS MICROBIOLOGY

Host restriction factors in retroviral infection: promises in virus-host interaction

(2012) Yong-Hui Zheng et al.   Retrovirology

Natural SIV Hosts: Showing AIDS the Door

(2012) Ann Chahroudi et al.   SCIENCE

Animal models of antiretroviral prophylaxis for HIV prevention

(2012) J. Gerardo García-Lerma et al.   Current Opinion in HIV and AIDS

New Paradigms for HIV/AIDS Vaccine Development

(2011) Louis J. Picker et al.   Annual Review of Medicine

Distinct Expression Patterns of CD69 in Mucosal and Systemic Lymphoid Tissues in Primary SIV Infection of Rhesus Macaques

(2011) Xiaolei Wang et al.   PLoS One

The Large Intestine as a Major Reservoir for Simian Immunodeficiency Virus in Macaques with Long‐Term, Nonprogressing Infection

(2010) Binhua Ling et al.   JOURNAL OF INFECTIOUS DISEASES

Targeting early infection to prevent HIV-1 mucosal transmission

(2010) Ashley T. Haase   NATURE

Island Biogeography Reveals the Deep History of SIV

(2010) M. Worobey et al.   SCIENCE

Impact of Simian Immunodeficiency Virus Infection on Chimpanzee Population Dynamics

(2010) Rebecca S. Rudicell et al.   PLoS Pathogens

Immune activation and AIDS pathogenesis

(2009) Donald L Sodora et al.   AIDS

Lessons Learned from the Natural Hosts of HIV-Related Viruses

(2009) Mirko Paiardini et al.   Annual Review of Medicine

Monitoring α4β7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection

(2009) X Wang et al.   Mucosal Immunology

Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz

(2009) Brandon F. Keele et al.   NATURE

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

(2009) Donald L Sodora et al.   NATURE MEDICINE

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

(2009) David Favre et al.   PLoS Pathogens

“Is it the cause?”—Robert Koch and viruses in the 21st century

(2008) Charles Richard Madeley   JOURNAL OF CLINICAL VIROLOGY

Persistence of HIV in Gut‐Associated Lymphoid Tissue despite Long‐Term Antiretroviral Therapy

(2008) Tae‐Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

(2008) James Arthos et al.   NATURE IMMUNOLOGY

A transitional endogenous lentivirus from the genome of a basal primate and implications for lentivirus evolution

(2008) R. J. Gifford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

(2008) B. F. Keele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts

(2008) Ivona Pandrea et al.   TRENDS IN IMMUNOLOGY

Nonpathogenic CCR2-tropic SIVrcm after serial passage and its effect on SIVmac infection of Indian rhesus macaques

(2008) Binhua Ling et al.   VIROLOGY