Dual Role of Novel Ingenol Derivatives from Euphorbia tirucalli in HIV Replication: Inhibition of De Novo Infection and Activation of Viral LTR

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins

(2013) Ann-Marie Cimo et al.   BIOCHEMICAL JOURNAL

CTIP2 is a negative regulator of P-TEFb

(2013) T. Cherrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

14-Step Synthesis of (+)-Ingenol from (+)-3-Carene

(2013) L. Jorgensen et al.   SCIENCE

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

(2013) Celsa A. Spina et al.   PLoS Pathogens

Long-term Follow-up Study of Ingenol Mebutate Gel for the Treatment of Actinic Keratoses

(2013) Mark Lebwohl et al.   JAMA Dermatology

Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

(2012) Sophie Bouchat et al.   AIDS

Activation of Latent HIV-1 Expression by Protein Kinase C Agonists. A Novel Therapeutic Approach to Eradicate HIV-1 Reservoirs

(2012) Gonzalo Sanchez-Duffhues et al.   CURRENT DRUG TARGETS

The role of cytokines in the establishment, persistence and eradication of the HIV reservoir

(2012) Claire Vandergeeten et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Targeting HIV latency: pharmacologic strategies toward eradication

(2012) Sifei Xing et al.   DRUG DISCOVERY TODAY

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication

(2012) Evelyn Eisele et al.   IMMUNITY

Latent HIV-1 Infection Occurs in Multiple Subsets of Hematopoietic Progenitor Cells and Is Reversed by NF- B Activation

(2012) L. A. McNamara et al.   JOURNAL OF VIROLOGY

In VitroPhenotypic Susceptibility of HIV-2 Clinical Isolates to CCR5 Inhibitors

(2011) Benoit Visseaux et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes

(2011) Roberto A Barrero et al.   BMC GENOMICS

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

(2011) J. Friedman et al.   JOURNAL OF VIROLOGY

Picomolar Dichotomous Activity of Gnidimacrin Against HIV-1

(2011) Li Huang et al.   PLoS One

Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity

(2011) P. A. Wender et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection in a Receptor Independent Manner

(2010) Rajeev Mehla et al.   PLoS One

Cell line-dependent variability in HIV activation employing DNMT inhibitors

(2010) Guerau Fernandez et al.   Virology Journal

The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity

(2010) Elisabeth Ersvaer et al.   Toxins

Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeficiency Virus Type 1 Activity

(2009) T. Huet et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection

(2009) Jesus F. Salazar-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

(2009) Laurence Colin et al.   Retrovirology

"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence

(2009) Andrea Savarino et al.   Retrovirology

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance

(2008) T. Shimamura et al.   CANCER RESEARCH

Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control

(2008) Stephen A. Migueles et al.   IMMUNITY

Practical Synthesis of Prostratin, DPP, and Their Analogs, Adjuvant Leads Against Latent HIV

(2008) P. A. Wender et al.   SCIENCE

Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation

(2007) Nieves Márquez et al.   BIOCHEMICAL PHARMACOLOGY