Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells

Role of Mitochondrial DNA Damage in the Development of Diabetic Retinopathy, and the Metabolic Memory Phenomenon Associated with Its Progression

(2010) Sally A. Madsen–Bouterse et al.   ANTIOXIDANTS & REDOX SIGNALING

DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression

(2010) Jing An et al.   BMC MOLECULAR BIOLOGY

PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis

(2010) Jerry E. Chipuk et al.   CELL CYCLE

‘Glycaemic variability’: a new therapeutic challenge in diabetes and the critical care setting

(2010) A. Ceriello et al.   DIABETIC MEDICINE

Hyperglycaemia and the vessel wall: the pathophysiological aspects on the atherosclerotic burden in patients with diabetes

(2010) Antonio Ceriello   EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase

(2010) Sally A. Madsen-Bouterse et al.   FREE RADICAL RESEARCH

Intermittent high glucose exacerbates the aberrant production of adiponectin and resistin through mitochondrial superoxide overproduction in adipocytes

(2010) Jiazhong Sun et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

Glycaemic variability and complications in patients with diabetes mellitus: evidence from a systematic review of the literature

(2009) L. Nalysnyk et al.   DIABETES OBESITY & METABOLISM

DNA-PKcs and ATM co-regulate DNA double-strand break repair

(2009) Meena Shrivastav et al.   DNA REPAIR

H2AX Is Required for Cell Cycle Arrest via the p53/p21 Pathway

(2009) M. Fragkos et al.   MOLECULAR AND CELLULAR BIOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Connecting obesity, aging and diabetes

(2009) Rexford S. Ahima   NATURE MEDICINE

Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

(2009) Pedro Geraldes et al.   NATURE MEDICINE

Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation

(2008) Amit Kulkarni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients

(2008) A. Ceriello et al.   DIABETES

Characterizing Glucose Exposure for Individuals with Normal Glucose Tolerance Using Continuous Glucose Monitoring and Ambulatory Glucose Profile Analysis

(2008) Roger S. Mazze et al.   Diabetes Technology & Therapeutics

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The “Metabolic Memory”: Is More Than Just Tight Glucose Control Necessary to Prevent Diabetic Complications?

(2008) Antonio Ceriello et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH