AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity

The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway

(2016) Nicola J. Maclaine et al.   Aging-US

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells

(2013) Emelie Karnevi et al.   BMC CANCER

Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK

(2013) Y Storozhuk et al.   BRITISH JOURNAL OF CANCER

Metformin Downregulates the Insulin/IGF-I Signaling Pathway and Inhibits Different Uterine Serous Carcinoma (USC) Cells Proliferation and Migration in p53-Dependent or -Independent Manners

(2013) Rive Sarfstein et al.   PLoS One

Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells

(2012) Dae-Hee Lee et al.   CELLULAR SIGNALLING

Inhibition of AMP-activated Protein Kinase α (AMPKα) by Doxorubicin Accentuates Genotoxic Stress and Cell Death in Mouse Embryonic Fibroblasts and Cardiomyocytes

(2012) Shaobin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Activates Tumor Suppressor p53 by Inducing ATR-Chk1 Kinase Cascade-mediated Phosphorylation and Consequent 14-3-3γ Inactivation of MDMX Protein

(2012) Jun-Ho Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin interacts with AMPK through binding to γ subunit

(2012) Yaya Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching

(2011) Sylvia Hilliard et al.   DEVELOPMENTAL BIOLOGY

In vitro and in vivo anti-melanoma action of metformin

(2011) Kristina Janjetovic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Salicylic acid derivatives: synthesis, features and usage as therapeutic tools

(2011) Deniz Ekinci et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Hydrophilic Residues Are Crucial for Ribosomal Protein L11 (RPL11) Interaction with Zinc Finger Domain of MDM2 and p53 Protein Activation

(2011) Qi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role for Noncoding 5S rRNA in Regulating Mdmx Stability

(2011) Muyang Li et al.   MOLECULAR CELL

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

(2011) V. Pant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

(2011) L. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

AMPK Activators as Novel Therapeutics for Type 2 Diabetes

(2010) Li-Fang Yu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Metformin sensitizes insulin signaling through AMPK-mediated pten down-regulation in preadipocyte 3T3-L1 cells

(2010) Soo Kyung Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases

(2009) Yunyuan V. Wang et al.   CANCER CELL

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

Aspirin, salicylates, and cancer

(2009) Peter C Elwood et al.   LANCET

The Origins and Evolution of the p53 Family of Genes

(2009) V. A. Belyi et al.   Cold Spring Harbor Perspectives in Biology

Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence

(2008) T. M. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA