The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy

ΔNp63/DGCR8-Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer

(2016) Marco Napoli et al.   CANCER CELL

p53 as guardian of the mitochondrial genome

(2016) Ji-Hoon Park et al.   FEBS LETTERS

Unifying the p73 knockout phenotypes: TAp73 orchestrates multiciliogenesis

(2016) Marco Napoli et al.   GENES & DEVELOPMENT

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

p53 Isoforms: Key Regulators of the Cell Fate Decision

(2016) Sebastien M. Joruiz et al.   Cold Spring Harbor Perspectives in Medicine

p53, ROS and senescence in the control of aging

(2016) Arnaud Vigneron et al.   Aging-US

Caloric restriction: is mammalian life extension linked to p53?

(2016) Paola Tucci   Aging-US

Dietary restriction, mitochondrial function and aging: from yeast to humans

(2015) Andrea Ruetenik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73

(2015) Avinashnarayan Venkatanarayan et al.   CELL CYCLE

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

(2015) Margarita R. Ramis et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The effect of statins on cancer cells—review

(2015) Lucyna Matusewicz et al.   TUMOR BIOLOGY

p53 regulates the mevalonate pathway in human glioblastoma multiforme

(2015) C Laezza et al.   Cell Death & Disease

DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations

(2014) Michela Restelli et al.   HUMAN MOLECULAR GENETICS

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo

(2014) Avinashnarayan Venkatanarayan et al.   NATURE

Induced multipotency in adult keratinocytes through down-regulation ofΔNp63orDGCR8

(2014) Deepavali Chakravarti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery

(2014) Mihaela Aldea et al.   TUMOR BIOLOGY

p53/p63/p73 in the Epidermis in Health and Disease

(2014) V. A. Botchkarev et al.   Cold Spring Harbor Perspectives in Medicine

p53 regulates glucose metabolism by miR-34a

(2013) Hwa-Ryeon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation

(2013) Peng Jiang et al.   CELL CYCLE

p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene

(2013) Z He et al.   CELL DEATH AND DIFFERENTIATION

Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

(2013) N Sanchez-Macedo et al.   CELL DEATH AND DIFFERENTIATION

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

The family that eats together stays together: new p53 family transcriptional targets in autophagy

(2013) M. Napoli et al.   GENES & DEVELOPMENT

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

Analysis of TAp73-Dependent Signaling via Omics Technologies

(2013) Angelo D’Alessandro et al.   JOURNAL OF PROTEOME RESEARCH

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo

(2013) Oleg Timofeev et al.   Cell Reports

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

The rebel angel: mutant p53 as the driving oncogene in breast cancer

(2012) D. Walerych et al.   CARCINOGENESIS

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

TAp63 Is a Master Transcriptional Regulator of Lipid and Glucose Metabolism

(2012) Xiaohua Su et al.   Cell Metabolism

Metabolic regulation of oxygen and redox homeostasis by p53: Lessons from evolutionary biology?

(2012) Jie Zhuang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The p53 family grows old

(2012) E. R. Flores et al.   GENES & DEVELOPMENT

TAp73 depletion accelerates aging through metabolic dysregulation

(2012) A. Rufini et al.   GENES & DEVELOPMENT

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

A new role of p53 in regulating lipid metabolism

(2012) Xingwu Wang et al.   Journal of Molecular Cell Biology

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

(2011) T. Contractor et al.   CANCER RESEARCH

Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors

(2011) R. Boidot et al.   CANCER RESEARCH

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Mieap, a p53-Inducible Protein, Controls Mitochondrial Quality by Repairing or Eliminating Unhealthy Mitochondria

(2011) Noriaki Kitamura et al.   PLoS One

Isoform-specific p73 knockout mice reveal a novel role for  Np73 in the DNA damage response pathway

(2010) M. T. Wilhelm et al.   GENES & DEVELOPMENT

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

(2010) Xiaohua Su et al.   NATURE

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAp63 Prevents Premature Aging by Promoting Adult Stem Cell Maintenance

(2009) Xiaohua Su et al.   Cell Stem Cell

p63 Promotes Cell Survival through Fatty Acid Synthase

(2009) Venkata Sabbisetti et al.   PLoS One

Tumor Protein 53-Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function

(2008) C. E. Cano et al.   CANCER RESEARCH

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

(2008) R. Tomasini et al.   GENES & DEVELOPMENT

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation

(2008) K. Hastak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA