p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer

Role of metabolism in cancer cell radioresistance and radiosensitization methods

(2018) Le Tang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mitochondrial fission and mitophagy depend on cofilin-mediated actin depolymerization activity at the mitochondrial fission site

(2018) Guo-Bing Li et al.   ONCOGENE

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

(2017) Elodie Villa et al.   Cell Reports

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Parkin Regulates the Activity of Pyruvate Kinase M2

(2016) Kun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy

(2016) Tongmei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin and mitophagy in cancer

(2016) J P Bernardini et al.   ONCOGENE

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

New method to assess mitophagy flux by flow cytometry

(2015) Marta Mauro-Lizcano et al.   Autophagy

The regulation of radiosensitivity by p53 and its acetylation

(2015) Jing Zhang et al.   CANCER LETTERS

Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function

(2015) N. V. Rajeshkumar et al.   CANCER RESEARCH

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy

(2015) Anne Hamacher-Brady et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis

(2015) A. H. Chourasia et al.   EMBO REPORTS

Effect of β-catenin silencing in overcoming radioresistance of head and neck cancer cells by antagonizing the effects of AMPK on Ku70/Ku80

(2015) Hyo Won Chang et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Energy Metabolism in a Matched Model of Radiation Resistance for Head and Neck Squamous Cell Cancer

(2015) Jade Mims et al.   RADIATION RESEARCH

Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells

(2015) Hui-Mei Wu et al.   Scientific Reports

Broad Phenotypic Changes Associated with Gain of Radiation Resistance in Head and Neck Squamous Cell Cancer

(2014) Nidhi Bansal et al.   ANTIOXIDANTS & REDOX SIGNALING

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response

(2014) R Lall et al.   CELL DEATH AND DIFFERENTIATION

Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy

(2014) Emilie Hollville et al.   MOLECULAR CELL

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic  -cell function in diabetes

(2014) A. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton

(2014) H Maes et al.   Cell Death & Disease

Regulation and function of mitophagy in development and cancer

(2013) Haiqi Lu et al.   Autophagy

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Tumour-associated mutant p53 drives the Warburg effect

(2013) Cen Zhang et al.   Nature Communications

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

(2011) Youngil Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence

(2011) H. D. Skinner et al.   CLINICAL CANCER RESEARCH

p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death

(2011) Xi Feng et al.   EMBO JOURNAL

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium

(2011) Åsa B. Gustafsson   PEDIATRIC CARDIOLOGY

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Incidence of isolated regional recurrence after definitive (chemo-) radiotherapy for head and neck squamous cell carcinoma

(2009) Maarten Lambrecht et al.   RADIOTHERAPY AND ONCOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY