Five-Step Total Synthesis of (±)-Aspidospermidine by a Lactam Strategy via an Azomethine Ylide

Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Ir and Chiral Thiourea Sequential Catalysis

(2021) Dong-Huang Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition‐Metal‐Free Reductive Functionalization of Tertiary Carboxamides and Lactams for α‐Branched Amine Synthesis

(2020) Derek Yiren Ong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reductive Functionalization of Carboxamides: A Recent Update

(2020) Derek Yiren Ong et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Total Syntheses of Dihydroindole Aspidosperma Alkaloids: Reductive Interrupted Fischer Indolization Followed by Redox Diversification

(2020) Gábor Martin et al.   ORGANIC LETTERS

Catalytic Reductive Functionalization of Tertiary Amides using Vaska’s Complex: Synthesis of Complex Tertiary Amine Building Blocks and Natural Products

(2020) Daniel Matheau-Raven et al.   ACS Catalysis

Reverse Polarity Reductive Functionalization of Tertiary Amides via a Dual Iridium-Catalyzed Hydrosilylation and Single Electron Transfer Strategy

(2020) Tatiana Rogova et al.   ACS Catalysis

Approach to Fully Substituted Cyclic Nitrones from N -Hydroxylactam Derivatives: Development and Application to the Total Synthesis of Cylindricine C

(2019) Shobu Hiraoka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (+)-Aspidospermidine

(2019) Hongjin Xu et al.   ORGANIC LETTERS

Protecting-Group-Free Formal Synthesis of Aspidospermidine: Ring-Opening Cyclization of Spirocyclopropane with Amine Followed by Regioselective Alkylations

(2019) Hisanori Nambu et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Transformations of Amides: Tactics and Recent Progress

(2018) Pei-Qiang Huang   ACTA CHIMICA SINICA

Iridium-Catalyzed Reductive Alkylations of Secondary Amides

(2018) Wei Ou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrozirconation of C=X Functionalities with Schwartz's Reagent

(2018) Michał M. Więcław et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Concise total synthesis of (±)-aspidospermidine and computational study: FT-IR, NMR, NBO, NLO, FMO, MEP diagrams

(2018) Goncagul Serdaroglu et al.   JOURNAL OF MOLECULAR STRUCTURE

Total synthesis of complex alkaloids by nucleophilic addition to amides

(2018) Takaaki Sato et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Iridium-catalyzed reductive Ugi-type reactions of tertiary amides

(2018) Lan-Gui Xie et al.   Nature Communications

Straightforward α-Amino Nitrile Synthesis Through Mo(CO)6 -Catalyzed Reductive Functionalization of Carboxamides

(2018) Paz Trillo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amide activation: an emerging tool for chemoselective synthesis

(2018) Daniel Kaiser et al.   CHEMICAL SOCIETY REVIEWS

Iridium-Catalyzed Reductive Nucleophilic Addition to Secondary Amides

(2018) Yoshito Takahashi et al.   ORGANIC LETTERS

Unified Total Synthesis of Stemoamide-Type Alkaloids by Chemoselective Assembly of Five-Membered Building Blocks

(2017) Makoto Yoritate et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directed Fischer Indolization as an Approach to the Total Syntheses of (+)-Aspidospermidine and (−)-Tabersonine

(2017) Joo-Young Kim et al.   ORGANIC LETTERS

Divergent Asymmetric Total Synthesis of (+)-Vincadifformine, (−)-Quebrachamine, (+)-Aspidospermidine, (−)-Aspidospermine, (−)-Pyrifolidine, and Related Natural Products

(2017) Nengzhong Wang et al.   ORGANIC LETTERS

Total Synthesis of (−)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution

(2017) Andrej Shemet et al.   ORGANIC LETTERS

Efficient syntheses of (−)-crinine and (−)-aspidospermidine, and the formal synthesis of (−)-minfiensine by enantioselective intramolecular dearomative cyclization

(2017) Kang Du et al.   Chemical Science

Enantioselective Pd-Catalyzed Allylic Alkylation Reactions of Dihydropyrido[1,2-a ]indolone Substrates: Efficient Syntheses of (−)-Goniomitine, (+)-Aspidospermidine, and (−)-Quebrachamine

(2016) Beau P. Pritchett et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (−)-Histrionicotoxin through a Stereoselective Radical Translocation-Cyclization Reaction

(2016) Manabu Sato et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expeditious and Divergent Total Syntheses of Aspidosperma Alkaloids Exploiting Iridium(I)-Catalyzed Generation of Reactive Enamine Intermediates

(2016) Peng Wen Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoselective reductive alkynylation of tertiary amides by Ir and Cu(i) bis-metal sequential catalysis

(2016) Pei-Qiang Huang et al.   CHEMICAL COMMUNICATIONS

Chemoselective reduction of carboxamides

(2016) Alexey Volkov et al.   CHEMICAL SOCIETY REVIEWS

Development and Scope of the Arene-Fused Domino Michael/Mannich Reaction: Application to the Total Syntheses of Aspidosperma Alkaloids (−)-Aspidospermidine, (−)-Tabersonine, and (−)-Vincadifformine

(2016) Senzhi Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

One-Pot Reductive 1,3-Dipolar Cycloaddition of Secondary Amides: A Two-Step Transformation of Primary Amides

(2016) Pei-Qiang Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

An Iridium-Catalyzed Reductive Approach to Nitrones from N-Hydroxyamides

(2016) Seiya Katahara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Strategy for the Construction of Both Enantiomers of the Octahydropyrroloquinolinone Ring System: Total Synthesis of (+)-Aspidospermidine

(2016) Ganesh Pandey et al.   ORGANIC LETTERS

Concise total synthesis of (±)-aspidospermidine

(2015) Haichen Ma et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Iridium-Catalyzed Chemoselective Reductive Nucleophilic Addition to N-Methoxyamides

(2015) Minami Nakajima et al.   ORGANIC LETTERS

Increasing the Reactivity of Amides towards Organometallic Reagents: An Overview

(2014) Vittorio Pace et al.   ADVANCED SYNTHESIS & CATALYSIS

Concise and Enantioselective Total Synthesis of (−)-Mehranine, (−)-Methylenebismehranine, and RelatedAspidospermaAlkaloids

(2014) Marius Mewald et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Reductive Nitro-Mannich Cyclization

(2014) Alex W. Gregory et al.   CHEMISTRY-A EUROPEAN JOURNAL

Unified Strategy to Monoterpene Indole Alkaloids: Total Syntheses of (±)-Goniomitine, (±)-1,2-Dehydroaspidospermidine, (±)-Aspidospermidine, (±)-Vincadifformine, and (±)-Kopsihainanine A

(2014) Olivier Wagnières et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nucleophilic addition to N-alkoxyamides

(2014) Takaaki Sato et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pd(II)-Catalyzed One-Step Construction of Cycloalkane-Fused Indoles and Its Application in Formal Synthesis of (±)-Aspidospermidine

(2014) Guoqin Xia et al.   ORGANIC LETTERS

Total Synthesis of (±)-Gephyrotoxin by Amide-Selective Reductive Nucleophilic Addition

(2013) Kenji Shirokane et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Palladium-Catalyzed Decarboxylative Allylation of Carbazolones: Total Synthesis of (−)-Aspidospermidine and (+)-Kopsihainanine A

(2013) Zeqian Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Domino Michael/Mannich/N-Alkylation Route to the Tetrahydrocarbazole Framework of Aspidosperma Alkaloids: Concise Total Syntheses of (−)-Aspidospermidine, (−)-Tabersonine, and (−)-Vincadifformine

(2013) Senzhi Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantiospecific total synthesis of indole alkaloids (+)-eburnamonine, (−)-aspidospermidine and (−)-quebrachamine

(2013) John Eugene Nidhiry et al.   TETRAHEDRON

Direct Transformation of Secondary Amides into Secondary Amines: Triflic Anhydride Activated Reductive Alkylation

(2012) Kai-Jiong Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products

(2012) Lindsay McMurray et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective Inter- and Intramolecular Formal [4+2] Cycloaddition of Cyclobutanones with Indoles and Total Synthesis of (±)-Aspidospermidine

(2012) Mizuki Kawano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Manzamine A and Related Alkaloids

(2012) Pavol Jakubec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(II)-Catalyzed Regioselective 2-Alkylation of Indoles via a Norbornene-Mediated C–H Activation: Mechanism and Applications

(2012) Lei Jiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thioamides and Thioformamides for Sequential Reactions with Organolithium and Grignard Reagents

(2011) Toshiaki Murai et al.   CHEMISTRY LETTERS

Collective synthesis of natural products by means of organocascade catalysis

(2011) Spencer B. Jones et al.   NATURE

A Direct Entry to Substituted N-Methoxyamines from N-Methoxyamides via N-Oxyiminium Ions

(2010) Kenji Shirokane et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation

(2010) Kai-Jiong Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Generation of Secondary, Tertiary, and Quaternary Centers by Geminal Disubstitution of Carbonyl Oxygens

(2010) Dieter Seebach   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Synthesis of Substituted N,O-Containing Bicyclic Compounds by Sequential Addition of Nucleophiles to N-Alkoxybicyclolactams

(2010) Guillaume Vincent et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine

(2010) Filippo De Simone et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (±)-Aspidospermidine Starting from 3-Ethyl-5-bromo-2-pyrone

(2010) Hyun-Kyu Cho et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

‘Aromatic ring umpolung’, a rapid access to the main core of several natural products

(2010) Kimiaka C. Guérard et al.   TETRAHEDRON

Highly efficient synthesis of aldenamines from carboxamides by iridium-catalyzed silane-reduction/dehydration under mild conditions

(2009) Yukihiro Motoyama et al.   CHEMICAL COMMUNICATIONS

Concise total synthesis of (±)-aspidospermidine via an oxidative Hosomi–Sakurai process

(2009) Cyrille Sabot et al.   CHEMICAL COMMUNICATIONS

Domino Double Michael−Claisen Cyclizations: A Powerful General Tool for Introducing Quaternary Stereocenters at C(4) of Cyclohexane-1,3-diones and Total Synthesis of Diverse Families of Sterically Congested Alkaloids

(2008) Teruhiko Ishikawa et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoselective Formation of Fused Tricyclic Amines from Acyclic Aldehydes by a Cascade Process Involving Condensation, Cyclization, and Dipolar Cycloaddition

(2008) Adam J. M. Burrell et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Construction of Quaternary Carbon Centers by Sequential Conjugate Addition of Lithium Amide and in Situ Alkylation: Utility in the Synthesis of (−)-Aspidospermidine

(2008) Mayuko Suzuki et al.   ORGANIC LETTERS

Amidyls in radical cascades. The total synthesis of (±)-aspidospermidine and (±)-13-deoxyserratine

(2008) Anne-Claude Callier-Dublanchet et al.   TETRAHEDRON