Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 29, Pages 11903-11907Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202004272
Keywords
amines; coupling reactions; Grignard reagents; reductive functionalization; sodium hydride
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Funding
- Nanyang Technological University (NTU)
- Singapore Ministry of Education [MOE2017-T2-1-064]
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A new method for the synthesis of alpha-branched amines by reductive functionalization of tertiary carboxamides and lactams is described. The process relies on the efficient and controlled reduction of tertiary amides by a sodium hydride/sodium iodide composite, in situ treatment of the resulting anionic hemiaminal with trimethylsilyl chloride and subsequent coupling with nucleophilic reagents including Grignard reagents and tetrabutylammonium cyanide. The new method exhibits broad functional-group compatibility, operates under transition-metal-free reaction conditions, and is suitable for various synthetic applications on both sub-millimole and on multigram scales.
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