Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 80, Pages 11967-11970Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc05318a
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Funding
- National Natural Science Foundation of China [21332007]
- Program for Changjiang Scholars and Innovative Research Teamin University (PCSIRT) of the Ministry of Education, China
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We report herein a convenient and versatile method for the direct reductive alkynylation of tertiary amides to give propargylic amines through sequential Ir-catalysed hydrosilylation-Cu(I)-catalysed alkynylation. The reactions proceed chemoselectively at the amide group in the presence of several sensitive functional groups including the very reactive aldehyde group on either the amide or the alkyne coupling partner. The method is general for tert-amides with or without alpha-hydrogen.
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