Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 21, Pages 3864-3875Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00733k
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Funding
- MEXT [15K05436]
- Tobe Maki foundation
- JSPS fellowship [15J05926]
- Grants-in-Aid for Scientific Research [15K05436, 15J05926] Funding Source: KAKEN
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Nucleophilic addition to amides has been recognized as a promising transformation for total synthesis of complex alkaloids. Amides can accept two different organometallic reagents through the nucleophilic addition, which enables it to serve as a stable surrogate of multi-substituted amines. However, the nucleophilic addition has been overlooked for a long time due to three main reasons: low electrophilicity of amide carbonyls, potential hydrolysis of the reaction intermediate and excess addition of an organometallic reagent. This mini review focuses on the recent progress of total synthesis of complex alkaloids based on the nucleophilic additions to N-alkoxyamides, tertiary amides and secondary amides.
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