Journal
CHEMISTRY LETTERS
Volume 41, Issue 1, Pages 2-8Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2012.2
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Funding
- Grants-in-Aid for Scientific Research [23550082, 22106514] Funding Source: KAKEN
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Sequential reactions of thioamides and thioformamides with organolithium and Grignard reagents are described. Thioiminium salts derived from these sulfur isologues of amides readily react with lithium acetylides to lead to several types of products, including alpha,beta-unsaturated ketones, whereas sequential additions of lithium acetylides and Grignard reagents afford propargyl-amines. The direct addition of organolithium and Grignard reagents to thioformamides proceeds with high efficiency to give a range of tertiary amines.
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