Journal
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
Volume 93, Issue 11, Pages 1339-1349Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.20200182
Keywords
Carboxamides; Amines; Reduction
Categories
Funding
- Nanyang Technological University (NTU)
- Singapore Ministry of Education [MOE2017-T21-064, MOE2019-T2-1-089]
Ask authors/readers for more resources
Carboxamides including lactams are readily available and bench-stable chemical feedstock, and thus their use in chemical synthesis for production of valuable compounds would be an attractive choice in various synthetic endeavors. This review highlights and discusses recent advances on deoxygenative reductive functionalization of carboxamides for the synthesis of alpha-branched amines, that is initiated by controlled single hydride delivery to the amide carbonyl group and terminated by downstream functionalization of the iminium intermediates. The protocols are categorized based on the types of the reduction processes including those with aluminum hydrides, the Schwartz's reagent, transition metal-catalyzed/mediated hydro-silylation, and sodium hydride-iodide composite.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available