The transferrin receptor: the cellular iron gate

Systemic iron homeostasis and erythropoiesis

(2017) George Papanikolaou et al.   IUBMB LIFE

Na+/H+Exchanger 9 Regulates Iron Mobilization at the Blood-Brain Barrier in Response to Iron Starvation

(2017) Rami Beydoun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs

(2017) Masanori Yoshinaga et al.   Cell Reports

EGFR regulates iron homeostasis to promote cancer growth through redistribution of transferrin receptor 1

(2016) Biao Wang et al.   CANCER LETTERS

Noninvasive Measurement of mTORC1 Signaling with 89 Zr-Transferrin

(2016) Charles Truillet et al.   CLINICAL CANCER RESEARCH

The mutual control of iron and erythropoiesis

(2016) C. Camaschella et al.   International Journal of Laboratory Hematology

Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression

(2016) Fumiyasu Okazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase

(2016) Hong Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haemochromatosis

(2016) Lawrie W Powell et al.   LANCET

Effects of Combined Tristetraprolin/Tumor Necrosis Factor Receptor Deficiency on the Splenic Transcriptome

(2016) Sonika Patial et al.   MOLECULAR AND CELLULAR BIOLOGY

Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice

(2016) Pavle Matak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

(2016) Roberto Bellelli et al.   Cell Reports

Biogenesis of cytosolic and nuclear iron–sulfur proteins and their role in genome stability

(2015) Viktoria Désirée Paul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis

(2015) Supak Jenkitkasemwong et al.   Cell Metabolism

Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver

(2015) Shunsuke Matsuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron and oxygen sensing: a tale of 2 interacting elements?

(2015) Robert J. Simpson et al.   Metallomics

Genome-Wide Identification of Fas/CD95 Alternative Splicing Regulators Reveals Links with Iron Homeostasis

(2015) J. Ramón Tejedor et al.   MOLECULAR CELL

Regulation of mitochondrial morphology and function by stearoylation of TFR1

(2015) Deniz Senyilmaz et al.   NATURE

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

(2015) Haifa H Jabara et al.   NATURE GENETICS

Anemia: progress in molecular mechanisms and therapies

(2015) Vijay G Sankaran et al.   NATURE MEDICINE

Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis

(2015) Alan C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting cancer by binding iron: Dissecting cellular signaling pathways

(2015) Goldie Y.L. Lui et al.   Oncotarget

MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis

(2015) Iryna Kindrat et al.   Oncotarget

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

(2015) Wenjing Xu et al.   Cell Reports

The importance of iron in pathophysiologic conditions

(2015) Raffaella Gozzelino et al.   Frontiers in Pharmacology

Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle

(2015) Tomasa Barrientos et al.   EBioMedicine

The second transferrin receptor regulates red blood cell production in mice

(2014) A. Nai et al.   BLOOD

A critical role for mTORC1 in erythropoiesis and anemia

(2014) Zachary A Knight et al.   eLife

Labile iron in cells and body fluids: physiology, pathology, and pharmacology

(2014) Zvi Ioav Cabantchik   Frontiers in Pharmacology

Coupling Heme and Iron Metabolism via Ferritin H Chain

(2013) Raffaella Gozzelino et al.   ANTIOXIDANTS & REDOX SIGNALING

Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor

(2013) H. Fujita et al.   JOURNAL OF CELL SCIENCE

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

Identification of transferrin receptor 1 as a hepatitis C virus entry factor

(2013) D. N. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When less is more: novel mechanisms of iron conservation

(2013) Marina Bayeva et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin

(2012) Marina Bayeva et al.   Cell Metabolism

Regulation of iron homeostasis by microRNAs

(2012) Mirco Castoldi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Luminal Iron Levels Govern Intestinal Tumorigenesis after Apc Loss In Vivo

(2012) Sorina Radulescu et al.   Cell Reports

Regulation of cellular iron metabolism

(2011) Jian Wang et al.   BIOCHEMICAL JOURNAL

Regulation of iron transport and the role of transferrin

(2011) Konstantinos Gkouvatsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hepcidin and iron regulation, 10 years later

(2011) T. Ganz   BLOOD

Proteome of ubiquitin/MVB pathway: possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation

(2011) Ryo Tachiyama et al.   GENES TO CELLS

5-Aza-2′-deoxycytidine Activates Iron Uptake and Heme Biosynthesis by Increasing c-Myc Nuclear Localization and Binding to the E-boxes of Transferrin Receptor 1 (TfR1) and Ferrochelatase (Fech) Genes

(2011) Bo Ning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Importance of the Stem Cell Marker Prominin-1/CD133 in the Uptake of Transferrin and in Iron Metabolism in Human Colon Cancer Caco-2 Cells

(2011) Erika Bourseau-Guilmain et al.   PLoS One

Iron Regulatory Proteins: From Molecular Mechanisms to Drug Development

(2010) Stefania Recalcati et al.   ANTIOXIDANTS & REDOX SIGNALING

Development of Human Single-Chain Antibodies to the Transferrin Receptor that Effectively Antagonize the Growth of Leukemias and Lymphomas

(2010) R. Crepin et al.   CANCER RESEARCH

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Hereditary Hemochromatosis: Pathogenesis, Diagnosis, and Treatment

(2010) Antonello Pietrangelo   GASTROENTEROLOGY

Binding and uptake of H-ferritin are mediated by human transferrin receptor-1

(2010) Li Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-320 targets transferrin receptor 1 (CD71) and inhibits cell proliferation

(2009) Dale G. Schaar et al.   EXPERIMENTAL HEMATOLOGY

Transferrin-Directed Internalization and Cycling of Transferrin Receptor 2

(2009) Juxing Chen et al.   TRAFFIC

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1

(2008) M. A. Kerenyi et al.   BLOOD

Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression

(2008) B.-M. Zhu et al.   BLOOD

Viral infection and iron metabolism

(2008) Hal Drakesmith et al.   NATURE REVIEWS MICROBIOLOGY

Regulation of iron acquisition and storage: consequences for iron-linked disorders

(2007) Ivana De Domenico et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY