Principles of Alternating Access in Multidrug and Toxin Extrusion (MATE) Transporters

Conserved binding site in the N-lobe of prokaryotic MATE transporters suggests a role for Na+ in ion-coupled drug efflux

(2021) Steven Castellano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence and structural determinants of ligand-dependent alternating access of a MATE transporter

(2020) Kevin L. Jagessar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the conformational impact of detergents on the integral membrane protein LeuT by global HDX-MS

(2020) Ingvar R. Möller et al.   Journal of Proteomics

Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter

(2020) Ruyu Jia et al.   Nature Communications

Visualizing conformation transitions of the Lipid II flippase MurJ

(2019) Alvin C. Y. Kuk et al.   Nature Communications

The N-terminal domain of an archaeal multidrug and toxin extrusion (MATE) transporter mediates proton coupling required for prokaryotic drug resistance

(2019) Kevin L. Jagessar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inward-facing conformation of a multidrug resistance MATE family transporter

(2019) Sandra Zakrzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural biology of the multidrug and toxic compound extrusion superfamily transporters

(2019) Tsukasa Kusakizako et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

On the ion coupling mechanism of the MATE transporter ClbM

(2019) Alexander Krah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Xenobiotic Extrusion Mechanism of the MATE Transporter NorM_PS from Pseudomonas stutzeri

(2018) Martin Lorenz Eisinger et al.   JOURNAL OF MOLECULAR BIOLOGY

Membrane Potential Is Required for MurJ Function

(2018) Frederick A. Rubino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

Sodium and proton coupling in the conformational cycle of a MATE antiporter fromVibrio cholerae

(2018) Derek P. Claxton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly conserved Na+-binding site in the N-lobe of prokaryotic multidrug MATE transporters

(2018) Emel Ficici et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens

(2018) Karl A. Hassan et al.   RESEARCH IN MICROBIOLOGY

The bacterial lipid II flippase MurJ functions by an alternating-access mechanism

(2018) Sujeet Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter

(2018) Tsukasa Kusakizako et al.   STRUCTURE

Direct protein-lipid interactions shape the conformational landscape of secondary transporters

(2018) Chloe Martens et al.   Nature Communications

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

(2017) Brandy Verhalen et al.   NATURE

Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer

(2017) Suraj Adhikary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Plant Multidrug and Toxic Compound Extrusion Family Protein

(2017) Yoshiki Tanaka et al.   STRUCTURE

Structural basis for xenobiotic extrusion by eukaryotic MATE transporter

(2017) Hirotake Miyauchi et al.   Nature Communications

Shared Molecular Mechanisms of Membrane Transporters

(2016) David Drew et al.   Annual Review of Biochemistry

Multidrug efflux pumps and their role in antibiotic and antiseptic resistance: a pharmacodynamic perspective

(2016) Sandrine Alibert et al.   Expert Opinion on Drug Metabolism & Toxicology

Identification of the High-affinity Substrate-binding Site of the Multidrug and Toxic Compound Extrusion (MATE) Family Transporter fromPseudomonas stutzeri

(2016) Laiyin Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disulfide Cross-linking of a Multidrug and Toxic Compound Extrusion Transporter Impacts Multidrug Efflux

(2016) Martha Radchenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the MOP flippase MurJ in an inward-facing conformation

(2016) Alvin C Y Kuk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protonation-dependent conformational dynamics of the multidrug transporter EmrE

(2016) Reza Dastvan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the MOP flippase MurJ in an inward-facing conformation

(2016) Alvin C Y Kuk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MATE transport of the E. coli-derived genotoxin colibactin

(2016) Jarrod J. Mousa et al.   Nature Microbiology

Structures of multidrug and toxic compound extrusion transporters and their mechanistic implications

(2015) Min Lu   Channels

Structure, mechanism and cooperation of bacterial multidrug transporters

(2015) Dijun Du et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Transporter Classification Database (TCDB): recent advances

(2015) Milton H. Saier et al.   NUCLEIC ACIDS RESEARCH

The AbgT family: A novel class of antimetabolite transporters

(2015) Jared A. Delmar et al.   PROTEIN SCIENCE

Structural basis for the blockade of MATE multidrug efflux pumps

(2015) Martha Radchenko et al.   Nature Communications

The NorM MATE Transporter from N. gonorrhoeae : Insights into Drug and Ion Binding from Atomistic Molecular Dynamics Simulations

(2014) Yuk Ming Leung et al.   BIOPHYSICAL JOURNAL

Multidrug Transport Protein NorM fromVibrio choleraeSimultaneously Couples to Sodium- and Proton-Motive Force

(2014) Yoonhee Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competition as a Way of Life for H+-Coupled Antiporters

(2014) Shimon Schuldiner   JOURNAL OF MOLECULAR BIOLOGY

A DTX/MATE-Type Transporter Facilitates Abscisic Acid Efflux and Modulates ABA Sensitivity and Drought Tolerance in Arabidopsis

(2014) Haiwen Zhang et al.   Molecular Plant

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Conformational dynamics of ligand-dependent alternating access in LeuT

(2014) Kelli Kazmier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Na+–Substrate Coupling in the Multidrug Antiporter NorM Probed with a Spin-Labeled Substrate

(2013) P. Ryan Steed et al.   BIOCHEMISTRY

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

(2013) Yoshiki Tanaka et al.   NATURE

Conformational ensemble of the sodium-coupled aspartate transporter

(2013) Elka R Georgieva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into H+-coupled multidrug extrusion by a MATE transporter

(2013) Min Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of a Na+-coupled, substrate-bound MATE multidrug transporter

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights on Na+binding and conformational dynamics in multidrug and toxic compound extrusion transporter NorM

(2013) Jianing Song et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Probing protein interactions with hydrogen/deuterium exchange and mass spectrometry—A review

(2012) Andrew J. Percy et al.   ANALYTICA CHIMICA ACTA

Ion Binding and Internal Hydration in the Multidrug Resistance Secondary Active Transporter NorM Investigated by Molecular Dynamics Simulations

(2012) Stefano Vanni et al.   BIOCHEMISTRY

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

(2011) Atsushi Yonezawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential hydrogen/deuterium exchange mass spectrometry analysis of protein–ligand interactions

(2011) Michael J Chalmers et al.   Expert Review of Proteomics

Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity

(2010) Takanori Nakamura et al.   BIOCHEMICAL PHARMACOLOGY

Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine

(2010) S. Ito et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structure of a cation-bound multidrug and toxic compound extrusion transporter

(2010) Xiao He et al.   NATURE

Membrane protein assembly into Nanodiscs

(2009) Timothy H. Bayburt et al.   FEBS LETTERS

Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial Cells

(2009) M. Tsuda et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Two MATE proteins play a role in iron efficiency in soybean

(2009) Elizabeth E. Rogers et al.   JOURNAL OF PLANT PHYSIOLOGY

Two functionally distinct members of the MATE (multi-drug and toxic compound extrusion) family of transporters potentially underlie two major aluminum tolerance QTLs in maize

(2009) Lyza G. Maron et al.   PLANT JOURNAL

A coordinated network of transporters with overlapping specificities provides a robust survival strategy

(2009) N. Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of glutamate residues in substrate recognition by human MATE1 polyspecific H+/organic cation exporter

(2008) Takuya Matsumoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Functional Cloning and Characterization of the Multidrug Efflux Pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli

(2008) F. Long et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY