Structures of multidrug and toxic compound extrusion transporters and their mechanistic implications

Functional Characteristics of Two Human MATE Transporters: Kinetics of Cimetidine Transport and Profiles of Iinhibition by Various Compounds

(2016) Kin-ya Ohta et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Structural basis for the blockade of MATE multidrug efflux pumps

(2015) Martha Radchenko et al.   Nature Communications

Competition as a Way of Life for H+-Coupled Antiporters

(2014) Shimon Schuldiner   JOURNAL OF MOLECULAR BIOLOGY

Functional and structural dynamics of NhaA, a prototype for Na+ and H+ antiporters, which are responsible for Na+ and H+ homeostasis in cells

(2013) Etana Padan   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structural basis for the inhibition of bacterial multidrug exporters

(2013) Ryosuke Nakashima et al.   NATURE

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

(2013) Yoshiki Tanaka et al.   NATURE

Structural insights into H+-coupled multidrug extrusion by a MATE transporter

(2013) Min Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of a Na+-coupled, substrate-bound MATE multidrug transporter

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigation of the sodium-binding sites in the sodium-coupled betaine transporter BetP

(2012) K. Khafizov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a cation-bound multidrug and toxic compound extrusion transporter

(2010) Xiao He et al.   NATURE

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Functional Cloning and Characterization of the Multidrug Efflux Pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli

(2008) F. Long et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY