Multidrug efflux pumps and their role in antibiotic and antiseptic resistance: a pharmacodynamic perspective

Optimization of a novel series of pyranopyridine RND efflux pump inhibitors

(2016) Zachary Aron et al.   CURRENT OPINION IN MICROBIOLOGY

A new Pseudomonas quinolone signal (PQS) binding partner: MexG

(2016) James T. Hodgkinson et al.   Chemical Science

Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity

(2016) Ewa Otręebska-Machaj et al.   Frontiers in Microbiology

A Transporter Interactome Is Essential for the Acquisition of Antimicrobial Resistance to Antibiotics

(2016) Yonatan Shuster et al.   PLoS One

The pseudo-atomic structure of an RND-type tripartite multidrug efflux pump

(2015) Dijun Du et al.   BIOLOGICAL CHEMISTRY

Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors

(2015) Son T. Nguyen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Prevalence of eight resistance-nodulation-division efflux pump genes in epidemiologically characterized Acinetobacter baumannii of worldwide origin

(2015) Jennifer Nowak et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Microspectrometric insights on the uptake of antibiotics at the single bacterial cell level

(2015) Bertrand Cinquin et al.   Scientific Reports

Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa

(2015) Jürg Dreier et al.   Frontiers in Microbiology

RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition

(2015) Henrietta Venter et al.   Frontiers in Microbiology

Recent advances toward a molecular mechanism of efflux pump inhibition

(2015) Timothy J. Opperman et al.   Frontiers in Microbiology

Structural basis of RND-type multidrug exporters

(2015) Akihito Yamaguchi et al.   Frontiers in Microbiology

Bacterial Multidrug Efflux Transporters

(2014) Jared A. Delmar et al.   Annual Review of Biophysics

Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design

(2014) Jessica M. A. Blair et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Intra-abdominal Infections: Etiology, Epidemiology, Microbiological Diagnosis and Antibiotic Resistance

(2014) G. Nicoletti et al.   JOURNAL OF CHEMOTHERAPY

Structure of the AcrAB–TolC multidrug efflux pump

(2014) Dijun Du et al.   NATURE

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Identification of Natural Compound Inhibitors for Multidrug Efflux Pumps of Escherichia coli and Pseudomonas aeruginosa Using In Silico High-Throughput Virtual Screening and In Vitro Validation

(2014) Vasudevan Aparna et al.   PLoS One

Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump

(2014) Thelma Ohene-Agyei et al.   MicrobiologyOpen

RND Efflux Pumps: Structural Information Translated into Function and Inhibition Mechanisms

(2013) Paolo Ruggerone et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Interplay between Three RND Efflux Pumps in Doxycycline-Selected Strains of Burkholderia thailandensis

(2013) Fabrice Vincent Biot et al.   PLoS One

Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin

(2012) Jadwiga Handzlik et al.   BIOORGANIC & MEDICINAL CHEMISTRY

RND type efflux pump system MexAB-OprM of pseudomonas aeruginosa selects bacterial languages, 3-oxo-acyl-homoserine lactones, for cell-to-cell communication

(2012) Shu Minagawa et al.   BMC MICROBIOLOGY

Efflux Pumps of Gram-Negative Bacteria, a New Target for New Molecules

(2012) Jean-Marie Pages et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Functional study of the novel multidrug efflux pump KexD from Klebsiella pneumoniae

(2012) Wakano Ogawa et al.   GENE

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

(2012) A. V. Vargiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance

(2012) E. C. Hobbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amine–alkyl derivatives of hydantoin: New tool to combat resistant bacteria

(2011) Jadwiga Handzlik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria

(2011) Jean-Michel Bolla et al.   FEBS LETTERS

Quorum Sensing in Gram-Negative Bacteria: Small-Molecule Modulation of AHL and AI-2 Quorum Sensing Pathways

(2010) Warren R. J. D. Galloway et al.   CHEMICAL REVIEWS

Managing antimicrobial resistance in intensive care units

(2010) Tejal N. Gandhi et al.   CRITICAL CARE MEDICINE

Progress and Challenges in Implementing the Research on ESKAPE Pathogens

(2010) Louis B. Rice   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains

(2010) Jacqueline Chevalier et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Does the Wide Use of Quaternary Ammonium Compounds Enhance the Selection and Spread of Antimicrobial Resistance and Thus Threaten Our Health?

(2010) Kristin Hegstad et al.   Microbial Drug Resistance

An alkylaminoquinazoline restores antibiotic activity in Gram-negative resistant isolates

(2010) A. Mahamoud et al.   MICROBIOLOGY-SGM

Quorum sensing in bacterial virulence

(2010) L. C. M. Antunes et al.   MICROBIOLOGY-SGM

The antibacterial lead discovery challenge

(2010)   NATURE REVIEWS DRUG DISCOVERY

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

(2010) Y. Takatsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geraniol Restores Antibiotic Activities against Multidrug-Resistant Isolates from Gram-Negative Species

(2009) V. Lorenzi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The clinical consequences of antimicrobial resistance

(2009) Louis B Rice   CURRENT OPINION IN MICROBIOLOGY

Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update

(2009) Jessica MA Blair et al.   CURRENT OPINION IN MICROBIOLOGY

Quorum sensing and social networking in the microbial world

(2009) S. Atkinson et al.   Journal of the Royal Society Interface

Synergistic interaction of eugenol with antibiotics against Gram negative bacteria

(2009) S. Hemaiswarya et al.   PHYTOMEDICINE

A coordinated network of transporters with overlapping specificities provides a robust survival strategy

(2009) N. Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RamA Confers Multidrug Resistance in Salmonella enterica via Increased Expression of acrB, Which Is Inhibited by Chlorpromazine

(2008) A. M. Bailey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanisms of drug efflux and strategies to combat them: Challenging the efflux pump of Gram-negative bacteria

(2008) Jean-Marie Pagès et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Promising Therapy of XDR-TB/MDR-TB with Thioridazine an Inhibitor of Bacterial Efflux Pumps

(2008) L. Amaral et al.   CURRENT DRUG TARGETS

New Methods for the Identification of Efflux Mediated MDR Bacteria, Genetic Assessment of Regulators and Efflux Pump Constituents, Characterization of Efflux Systems and Screening for Inhibitors of Efflux Pumps

(2008) M. Viveiros et al.   CURRENT DRUG TARGETS

Membrane Permeability and Regulation of Drug “Influx and Efflux” in Enterobacterial Pathogens

(2008) Anne Davin-Regli et al.   CURRENT DRUG TARGETS

Potential of old-generation antibiotics to address current need for new antibiotics

(2008) Matthew E Falagas et al.   Expert Review of Anti-Infective Therapy

Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities

(2008) Marta Martins et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis

(2008) L. Rodrigues et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli

(2008) Minna Hannula et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

(2008) Ian Chopra et al.   LANCET INFECTIOUS DISEASES

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

(2008) Jean-Marie Pagès et al.   NATURE REVIEWS MICROBIOLOGY

Positive antibacterial co-action between hop (Humulus lupulus) constituents and selected antibiotics

(2008) P. Natarajan et al.   PHYTOMEDICINE