Differential hydrogen/deuterium exchange mass spectrometry analysis of protein–ligand interactions

Effective Removal of Nonionic Detergents in Protein Mass Spectrometry, Hydrogen/Deuterium Exchange, and Proteomics

(2010) Martial Rey et al.   ANALYTICAL CHEMISTRY

Dynamics of the β2-Adrenergic G-Protein Coupled Receptor Revealed by Hydrogen−Deuterium Exchange

(2010) Xi Zhang et al.   ANALYTICAL CHEMISTRY

Online, High-Pressure Digestion System for Protein Characterization by Hydrogen/Deuterium Exchange and Mass Spectrometry

(2010) Lisa M. Jones et al.   ANALYTICAL CHEMISTRY

Advantages of Isotopic Depletion of Proteins for Hydrogen/Deuterium Exchange Experiments Monitored by Mass Spectrometry

(2010) George M. Bou-Assaf et al.   ANALYTICAL CHEMISTRY

Conformational Analysis of Membrane Proteins in Phospholipid Bilayer Nanodiscs by Hydrogen Exchange Mass Spectrometry

(2010) Christine M. Hebling et al.   ANALYTICAL CHEMISTRY

Deuteration distribution estimation with improved sequence coverage for HX/MS experiments

(2010) Xinghua Lou et al.   BIOINFORMATICS

Discovery and Characterization of the Laulimalide-Microtubule Binding Mode by Mass Shift Perturbation Mapping

(2010) Melissa J. Bennett et al.   CHEMISTRY & BIOLOGY

Automated data reduction for hydrogen/deuterium exchange experiments, enabled by high-resolution fourier transform ion cyclotron resonance mass spectrometry

(2010) Sasa Kazazic et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

(2010) Jianming Zhang et al.   NATURE

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements

(2010) G. M. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry

(2010) Hui-Min Zhang et al.   PROTEIN SCIENCE

Hydrogen/Deuterium Exchange Reveals Distinct Agonist/Partial Agonist Receptor Dynamics within Vitamin D Receptor/Retinoid X Receptor Heterodimer

(2010) Jun Zhang et al.   STRUCTURE

Evidence of Functional Protein Dynamics from X-Ray Crystallographic Ensembles

(2010) Jonathan E. Kohn et al.   PLoS Computational Biology

H/D Exchange and Mass Spectrometry in the Studies of Protein Conformation and Dynamics: Is There a Need for a Top-Down Approach?

(2009) Igor A. Kaltashov et al.   ANALYTICAL CHEMISTRY

Protein Hydrogen Exchange Measured at Single-Residue Resolution by Electron Transfer Dissociation Mass Spectrometry

(2009) Kasper D. Rand et al.   ANALYTICAL CHEMISTRY

Gas-Phase Hydrogen/Deuterium Exchange in a Traveling Wave Ion Guide for the Examination of Protein Conformations

(2009) Kasper D. Rand et al.   ANALYTICAL CHEMISTRY

Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

(2009) John R. Engen   ANALYTICAL CHEMISTRY

Unique Ligand Binding Patterns between Estrogen Receptor α and β Revealed by Hydrogen−Deuterium Exchange

(2009) Susie Y. Dai et al.   BIOCHEMISTRY

Hydra: software for tailored processing of H/D exchange data from MS or tandem MS analyses

(2009) Gordon W Slysz et al.   BMC BIOINFORMATICS

Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands

(2009) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen/Deuterium Exchange Mass Spectrometry with Top-Down Electron Capture Dissociation for Characterizing Structural Transitions of a 17 kDa Protein

(2009) Jingxi Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Painting proteins with covalent labels: What’s in the picture?

(2009) Michael C. Fitzgerald et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Conformational disturbance in Abl kinase upon mutation and deregulation

(2009) R. E. Iacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry

(2009) Palaniappan Sevugan Chetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

(2009) K. S. Gajiwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human glucocorticoid receptor: Molecular basis of biologic function

(2009) Nicolas C. Nicolaides et al.   STEROIDS

High-Speed and High-Resolution UPLC Separation at Zero Degrees Celsius

(2008) Thomas E. Wales et al.   ANALYTICAL CHEMISTRY

Abl N-Terminal Cap Stabilization of SH3 Domain Dynamics†

(2008) Shugui Chen et al.   BIOCHEMISTRY

Sequence-Specific Conformational Flexibility of SNARE Transmembrane Helices Probed by Hydrogen/Deuterium Exchange

(2008) Walter Stelzer et al.   BIOPHYSICAL JOURNAL

"TOF2H": A precision toolbox for rapid, high density/high coverage hydrogen-deuterium exchange mass spectrometry via an LC-MALDI approach, covering the data pipeline from spectral acquisition to HDX rate analysis

(2008) Pornpat Nikamanon et al.   BMC BIOINFORMATICS

Tyrosine Phosphorylation in the SH3 Domain Disrupts Negative Regulatory Interactions within the c-Abl Kinase Core

(2008) Shugui Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Electron Transfer Dissociation Facilitates the Measurement of Deuterium Incorporation into Selectively Labeled Peptides with Single Residue Resolution

(2008) Martin Zehl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electron Capture Dissociation Proceeds with a Low Degree of Intramolecular Migration of Peptide Amide Hydrogens

(2008) Kasper D. Rand et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strong Anion Exchange for Studying Protein–DNA Interactions by H/D Exchange Mass Spectrometry

(2008) Justin B. Sperry et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

HD desktop: An integrated platform for the analysis and visualization of H/D exchange data

(2008) Bruce D. Pascal et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins

(2008) Nathan HyunJoong Joh et al.   NATURE

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method

(2008) S. Y. Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of the repeatability and reproducibility of hydrogen/deuterium exchange mass spectrometry measurements

(2008) William Burkitt et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange

(2008) Roxana E. Iacob et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Specificity of immobilized porcine pepsin in H/D exchange compatible conditions

(2008) Yoshitomo Hamuro et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY