AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury

The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity

(2020) Kerstin N. Timm et al.   CARDIOVASCULAR DRUGS AND THERAPY

Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2‐related programmed cell death in an AMPK‐dependent manner

(2020) Chunyan Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages

(2020) Qin Fei et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Exendin-4 Protects Against Myocardial Ischemia-Reperfusion Injury by Upregulation of SIRT1 and SIRT3 and Activation of AMPK

(2020) Refaat A. Eid et al.   Journal of Cardiovascular Translational Research

CTRP9 Mediates Protective Effects in Cardiomyocytes via AMPK- and Adiponectin Receptor-Mediated Induction of Anti-Oxidant Response

(2020) Bernd Niemann et al.   Cells

Mitochondrial ROS in myocardial ischemia reperfusion and remodeling

(2020) Heiko Bugger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endothelial α1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction

(2019) Swenja Kröller-Schön et al.   BASIC RESEARCH IN CARDIOLOGY

Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1

(2019) Santie Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

The cardiomyocyte “redox rheostat”: Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death

(2019) Daniel N. Meijles et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE

(2019) Juan Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activated protein C protects against pressure overload-induced hypertrophy through AMPK signaling

(2018) Courtney Cates et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK-ACC signaling modulates platelet phospholipids content and potentiates platelet function and thrombus formation

(2018) Sophie Lepropre et al.   BLOOD

Pathological Remodeling of the Myocardium in Chronic Heart Failure: Role of PGC-1α

(2018) T. G. Kulikova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

PCSK9 expression in the ischaemic heart and its relationship to infarct size, cardiac function, and development of autophagy

(2018) Zufeng Ding et al.   CARDIOVASCULAR RESEARCH

OUP accepted manuscript

(2018)   CARDIOVASCULAR RESEARCH

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Oxidant sensor cation channel TRPM2 regulates neutrophil extracellular trap formation and protects against pneumoseptic bacterial infection

(2018) Jitendra Kumar Tripathi et al.   FASEB JOURNAL

Cardioprotective Effects of Metformin

(2018) Christine Driver et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells

(2018) Ricardo J. Antonia et al.   Science Signaling

Pharmacological inhibition of the mitochondrial NADPH oxidase 4/PKCα/Gal-3 pathway reduces left ventricular fibrosis following myocardial infarction

(2018) Maria del Carmen Asensio-Lopez et al.   Translational Research

AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

(2018) Roselle Gélinas et al.   Nature Communications

IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells

(2018) Ricardo J. Antonia et al.   Science Signaling

Is TAK1 a Direct Upstream Kinase of AMPK?

(2018) Dietbert Neumann   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

(2018) Elizabeth C Hinchy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac and Renal Effects of Sodium-Glucose Co-Transporter 2 Inhibitors in Diabetes

(2018) Thomas A. Zelniker et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Vascular Biology of Superoxide-Generating NADPH Oxidase 5—Implications in Hypertension and Cardiovascular Disease

(2018) Rhian M. Touyz et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance

(2018) Baile Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling

(2018) Luopei Wang et al.   PHYTOMEDICINE

Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway

(2017) Jialin Duan et al.   Scientific Reports

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation

(2017) Bei Wang et al.   CIRCULATION RESEARCH

Metformin attenuates myocardial ischemia-reperfusion injury via up-regulation of antioxidant enzymes

(2017) Xiaoling Wang et al.   PLoS One

C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and FailureNovelty and Significance

(2016) Mahesh Appari et al.   CIRCULATION RESEARCH

Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes

(2016) Manasi S. Shah et al.   CIRCULATION RESEARCH

Myeloid Deletion of α1AMPK Exacerbates Atherosclerosis in LDL Receptor Knockout (LDLRKO) Mice

(2016) Qiang Cao et al.   DIABETES

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

(2016) Fiona A. Ross et al.   FEBS Journal

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism

(2016) Karla Reichert et al.   PLoS One

Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-β/Smad3 pathway

(2015) Tongshuai Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Probing the enzyme kinetics, allosteric modulation and activation of  1- and  2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

(2015) F. Rajamohan et al.   BIOCHEMICAL JOURNAL

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NF B Signaling Pathways

(2015) Q. D. Zhao et al.   CIRCULATION

Redox biomarkers in cardiovascular medicine

(2015) Keyvan Karimi Galougahi et al.   EUROPEAN HEART JOURNAL

The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1–p70S6K–RPS6 signaling

(2015) Timothy D. Calamaras et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of pioglitazone on cardiac and adipose tissue pathology in rats with metabolic syndrome

(2015) Natsumi Matsuura et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A time to reap, a time to sow: Mitophagy and biogenesis in cardiac pathophysiology

(2015) Allen M. Andres et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

AMPK: energy sensor and survival mechanism in the ischemic heart

(2015) Dake Qi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cardiac Fibrosis Alleviated by Exercise Training Is AMPK-Dependent

(2015) Xiaowei Ma et al.   PLoS One

AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes

(2014) Magali Balteau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake

(2014) Aurélie D. Timmermans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1

(2014) Yanh Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

AMPK-Dependent Inhibitory Phosphorylation of ACC Is Not Essential for Maintaining Myocardial Fatty Acid Oxidation

(2014) Beshay N.M. Zordoky et al.   CIRCULATION RESEARCH

Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP

(2014) F. Romana Auciello et al.   FEBS LETTERS

Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure

(2014) X.S. Gu et al.   GENETICS AND MOLECULAR RESEARCH

Endothelial Dysfunction and Hypertension

(2014) Ralf P. Brandes   HYPERTENSION

Metformin Protects Against Systolic Overload–Induced Heart Failure Independent of AMP-Activated Protein Kinase α2

(2014) Xin Xu et al.   HYPERTENSION

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Oleuropein prevents doxorubicin-induced cardiomyopathy interfering with signaling molecules and cardiomyocyte metabolism

(2014) Ioanna Andreadou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart

(2014) Thomas K. Sin et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Ca2+/calmodulin-dependent kinase kinase β-AMP-activated protein kinase-α1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets

(2014) M.-B. Onselaer et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels

(2014) D. Grahame Hardie et al.   PHYSIOLOGY

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1 

(2014) B. Faubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells

(2014) X Zhou et al.   Cell Death & Disease

Protective effect of resveratrol against pressure overload-induced heart failure

(2014) Prakash K. Gupta et al.   Food Science & Nutrition

Monoamine Oxidase B Prompts Mitochondrial and Cardiac Dysfunction in Pressure Overloaded Hearts

(2013) Nina Kaludercic et al.   ANTIOXIDANTS & REDOX SIGNALING

Transforming Growth Factor-β–Activated Kinase 1 Regulates Angiogenesis via AMP-Activated Protein Kinase-α1 and Redox Balance in Endothelial Cells

(2013) Nina Zippel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells

(2013) Battsetseg Batchuluun et al.   ATHEROSCLEROSIS

Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice

(2013) Vernon W. Dolinsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart

(2013) Bénédicte Demeulder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

(2013) Rémi Mounier et al.   Cell Metabolism

Regulation of ion channels and transporters by AMP-activated kinase (AMPK)

(2013) Florian Lang et al.   Channels

AMP-Activated Protein Kinase Regulates Endothelial Cell Angiotensin-Converting Enzyme Expression via p53 and the Post-Transcriptional Regulation of microRNA-143/145

(2013) Karin Kohlstedt et al.   CIRCULATION RESEARCH

Comparative Safety and Effectiveness of Metformin in Patients With Diabetes Mellitus and Heart Failure

(2013) Dean T. Eurich et al.   Circulation-Heart Failure

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PPAR-γ activation by rosiglitazone suppresses angiotensin II-mediated proliferation and phenotypictransition in cardiac fibroblasts via inhibition of activation of activator protein 1

(2013) Xiaoyang Hou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling

(2013) Kelly Casey Carroll et al.   JOURNAL OF LEUKOCYTE BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart

(2012) Vlad G. Zaha et al.   CIRCULATION RESEARCH

The Role of PPARα in Metformin-Induced Attenuation of Mitochondrial Dysfunction in Acute Cardiac Ischemia/Reperfusion in Rats

(2012) Giselle Barreto-Torres et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of AMP-activated Protein Kinase α (AMPKα) by Doxorubicin Accentuates Genotoxic Stress and Cell Death in Mouse Embryonic Fibroblasts and Cardiomyocytes

(2012) Shaobin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Oxygen Species in Health and Disease

(2012) Assim A. Alfadda et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Markers of Oxidative Damage and Antioxidant Enzyme Activities as Predictors of Morbidity and Mortality in Patients With Chronic Heart Failure

(2012) Slavica Radovanovic et al.   JOURNAL OF CARDIAC FAILURE

AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats

(2012) Rebecca J. Ford et al.   JOURNAL OF HYPERTENSION

AMPK isoform expression in the normal and failing hearts

(2012) Maengjo Kim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metformin attenuates pressure overload-induced cardiac hypertrophy via AMPK activation

(2011) Yong-nan Fu et al.   ACTA PHARMACOLOGICA SINICA

O-linked β-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells

(2011) Howard Goldberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury

(2011) Marta A. Paiva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oxidative stress and heart failure

(2011) Hiroyuki Tsutsui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

α1AMP-Activated Protein Kinase Preserves Endothelial Function During Chronic Angiotensin II Treatment by Limiting Nox2 Upregulation

(2011) Swenja Schuhmacher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies

(2011) Alexander Sirker et al.   BASIC RESEARCH IN CARDIOLOGY

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes

(2011) J. W. Rowley et al.   BLOOD

Endothelial nitric oxide synthase of the bone marrow regulates myocardial hypertrophy, fibrosis, and angiogenesis

(2011) Andrey Kazakov et al.   CARDIOVASCULAR RESEARCH

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

(2011) Siobhan M. Craige et al.   CIRCULATION

cGMP/PKG pathway mediates myocardial postconditioning protection in rat hearts by delaying normalization of intracellular acidosis during reperfusion

(2011) Javier Inserte et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice

(2011) Hye-Na Cha et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels

(2011) P. T. Mungai et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation

(2011) G. A. Gusarova et al.   MOLECULAR AND CELLULAR BIOLOGY

NOX Isoforms and Reactive Oxygen Species in Vascular Health

(2011) R. M. Touyz et al.   MOLECULAR INTERVENTIONS

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Contribution of Delayed Intracellular pH Recovery to Ischemic Postconditioning Protection

(2010) Javier Inserte et al.   ANTIOXIDANTS & REDOX SIGNALING

Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury

(2010) Nina Kaludercic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

AMPK  2 subunit is involved in platelet signaling, clot retraction, and thrombus stability

(2010) V. Randriamboavonjy et al.   BLOOD

Transitory Activation of AMPK at Reperfusion Protects the Ischaemic-Reperfused Rat Myocardium Against Infarction

(2010) Marta A. Paiva et al.   CARDIOVASCULAR DRUGS AND THERAPY

Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation

(2010) Masanori Konishi et al.   CARDIOVASCULAR RESEARCH

Metformin attenuates cardiac fibrosis by inhibiting the TGFβ1–Smad3 signalling pathway

(2010) Han Xiao et al.   CARDIOVASCULAR RESEARCH

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

AMPKα2 Deletion Causes Aberrant Expression and Activation of NAD(P)H Oxidase and Consequent Endothelial Dysfunction In Vivo

(2010) Shuangxi Wang et al.   CIRCULATION RESEARCH

Regulation of mitochondrial biogenesis

(2010) François R. Jornayvaz et al.   Essays in Biochemistry

NADPH oxidases in cardiovascular disease

(2010) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

LKB1 Deficiency in Tie2-Cre-expressing Cells Impairs Ischemia-induced Angiogenesis

(2010) Koji Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rosiglitazone reverses cardiac adverse remodeling (fibrosis and vascularization) in perinatal low protein rat offspring

(2010) Thiago da Silva Torres et al.   PATHOLOGY RESEARCH AND PRACTICE

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models

(2010) Jennifer Rivera et al.   REDOX REPORT

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Metformin Prevents Progression of Heart Failure in Dogs

(2009) Hideyuki Sasaki et al.   CIRCULATION

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

(2009) Vernon W. Dolinsky et al.   CIRCULATION

Autophagy in Ischemic Heart Disease

(2009) Åsa B. Gustafsson et al.   CIRCULATION RESEARCH

AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633

(2009) Zhen Chen et al.   CIRCULATION RESEARCH

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

(2009) Brooke M. Emerling et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase

(2009) Yasukatsu Izumi et al.   HYPERTENSION RESEARCH

 1-AMP-Activated Protein Kinase Regulates Hypoxia-Induced Na,K-ATPase Endocytosis via Direct Phosphorylation of Protein Kinase C 

(2009) G. A. Gusarova et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

(2009) D. B. Shackelford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adiponectin Protects Against Angiotensin II–Induced Cardiac Fibrosis Through Activation of PPAR-α

(2008) Koichi Fujita et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AMPKα2 counteracts the development of cardiac hypertrophy induced by isoproterenol

(2008) Elham Zarrinpashneh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells

(2008) Seung-Nam Jung et al.   CARCINOGENESIS

Suppression of the JNK Pathway by Induction of a Metabolic Stress Response Prevents Vascular Injury and Dysfunction

(2008) E. Schulz et al.   CIRCULATION

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

(2008) Susheel Gundewar et al.   CIRCULATION RESEARCH

AMP Activated Protein Kinase-α2 Deficiency Exacerbates Pressure-Overload–Induced Left Ventricular Hypertrophy and Dysfunction in Mice

(2008) Ping Zhang et al.   HYPERTENSION

Metabolic Switch and Hypertrophy of Cardiomyocytes following Treatment with Angiotensin II Are Prevented by AMP-activated Protein Kinase

(2008) Bettina Johanna Stuck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated Protein Kinase Phosphorylates and Desensitizes Smooth Muscle Myosin Light Chain Kinase

(2008) Sandrine Horman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt

(2008) Anita Y. M. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK and Raptor: Matching Cell Growth to Energy Supply

(2008) D. Grahame Hardie   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

(2008) Che-Hong Chen et al.   SCIENCE

Thromboxane Receptor Activates the AMP-Activated Protein Kinase in Vascular Smooth Muscle Cells via Hydrogen Peroxide

(2007) Miao Zhang et al.   CIRCULATION RESEARCH