Article
Plant Sciences
Xiyang Yang, Xingbing Li, Minghao Luo, Yongzheng Guo, Chang Li, Dingyi Lv, Zhe Cheng, Longxiang Huang, Fei-Fei Shang, Bi Huang, Jian Shen, Suxin Luo, Jianghong Yan
Summary: Tubeimoside I (TBM) promotes angiogenesis through the activation of the eNOS-VEGF signaling pathway, making it a potential novel therapeutic agent for ischemic diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Fang Yuan, Cuiling Zhang, Xianzhu Luo, Xiaokun Shen, Yuezhong Xian
Summary: ATP stimulus-responsive tetrahedral DNA-gated fluorescent covalent organic frameworks (COFs) were developed for estradiol (E2) delivery and controllable release. The fluorescent COFs with an efficient E2 loading showed great potential against myocardial ischemia and reperfusion injury.
CHEMICAL COMMUNICATIONS
(2023)
Review
Cell Biology
Francesca Fagiani, Marieva Vlachou, Daniele Di Marino, Ilaria Canobbio, Alice Romagnoli, Marco Racchi, Stefano Govoni, Cristina Lanni
Summary: Pin1 functions as a key regulator of vascular homeostasis by modulating nitric oxide bioavailability and influencing various pathways involved in vascular diseases. Understanding the role of Pin1 in vascular endothelium could provide new insights for potential therapeutic strategies in vascular pathologies and neurodegenerative diseases.
Review
Biochemistry & Molecular Biology
Esteban Colombo, Antonio Signore, Stefano Aicardi, Angelina Zekiy, Anatoliy Utyuzh, Stefano Benedicenti, Andrea Amaroli
Summary: The review highlights the potential of photobiomodulation (PBM) in modulating endothelial dysfunction to improve arterial inflammation, angiogenesis, and vasodilatation. Studies suggest that specific light parameters can prevent restenosis and stimulate angiogenesis, as well as support hypertension treatment, although more randomized controlled trials are needed for further validation.
Article
Biochemistry & Molecular Biology
Ivana Tolj, Ana Stupin, Ines Drenjancevic, Petar Susnjara, Leon Peric, Marko Stupin
Summary: This study aimed to investigate the specific role of nitric oxide (NO) in micro- and macrovascular response to a 7-day high-salt (HS) diet in healthy individuals. It found that the HS diet resulted in impaired NO-mediated endothelial vasodilation, with increased eNOS, decreased nNOS, and unchanged iNOS concentration and NO serum level. The study also failed to support the concept of non-osmotic sodium storage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Tian-tian Liu, Huan-huan Xu, Ze-juan Liu, He-ping Zhang, Hai-tao Zhou, Zhi-xiang Zhu, Zhi-qiang Wang, Jing-yi Xue, Qiang Li, Yi Ma, Hong-jie You, Da-li Luo
Summary: Endothelial dysfunction is a central characteristic of cardiovascular pathogenesis in diabetes mellitus, characterized by impaired eNOS and NO bioavailability. This study identified the role of CaM in the dysfunction of eNOS in diabetes. Downregulated CaM expression was found to be responsible for endothelial injury and impaired angiogenesis in diabetes. The findings provide a novel mechanism and target for protecting against diabetic endothelial injury.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Multidisciplinary Sciences
Shuhan Bu, Hien C. Nguyen, Sepideh Nikfarjam, David C. R. Michels, Berk Rasheed, Sauraish Maheshkumar, Shweta Singh, Krishna K. Singh
Summary: The endothelium maintains vascular homeostasis by balancing vasorelaxation and vasoconstriction through regulating Nitric Oxide (NO) availability. Endothelial nitric oxide synthase (eNOS) is involved in this process and regulates endothelial function such as cell proliferation, migration, and tube formation. Inhibition of eNOS through genetic or pharmacologic methods has shown differential effects on endothelial cell behavior, suggesting a more complex mechanism behind eNOS regulation.
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Loshini Soundararajan, Arunasalam Dharmarajan, Priyanka Samji
Summary: Nitric Oxide (NO) is a diffusible and ubiquitous signaling molecule synthesized by our body, with pleiotropic effects due to its reactivity with different molecules. The role of NO in oncology is contradictory, as it can both promote and inhibit tumor growth depending on concentration and duration of exposure. Understanding the bimodal action of NO in different cancers is important for developing NO-based therapeutic strategies.
CELLULAR SIGNALLING
(2023)
Article
Pharmacology & Pharmacy
Zenghui Liang, Huafang Chen, Xuehao Gong, Binbin Shi, Lili Lin, Fangyi Tao, Qilong Wu, Mingling Fang, Hui Li, Cuitao Lu, Helin Xu, Yingzheng Zhao, Bin Chen
Summary: This study investigated the potential of using nitric oxide-loaded microbubbles and ultrasound to treat thromboembolism. The results showed that this treatment significantly reduced thrombus area, increased recanalization rates and blood flow velocities. The treatment also activated endothelial nitric oxide synthase and mitigated oxidative stress and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Lingling Xu, Yihan Chen, Qiaofeng Jin, Tang Gao, Cheng Deng, Rui Wang, Yihui Wang, Ying Bai, Jia Xu, Wenqian Wu, He Li, Lingyun Fang, Jing Wang, Yali Yang, Li Zhang, Qing Lv, Mingxing Xie
Summary: A platelet membrane-coated nanoparticle (B-P@PLT) with an ultrasound-responsive nitric oxide (NO) donor is developed for targeted treatment of myocardial ischemia reperfusion injury (MIRI). B-P@PLT can specifically target the ischemic myocardium and release NO during ultrasound irradiation, increasing the local concentration of NO. B-P@PLT + US shows promising results in promoting angiogenesis, reducing reactive oxygen species production, and protecting cardiomyocytes in vitro and in vivo, improving heart function in MIRI.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chiao-Chi Chen, Chen Chang, Ming-Fang Lin, Guo-Shu Huang, Wing P. Chan
Summary: During acute ischemic stroke, the interaction between deoxyhemoglobin and nitric oxide can be detected using MRI, serving as a sensitive marker for assessing tissue oxygenation status in the ischemic region.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Article
Cell Biology
Livius d'Uscio, Zvonimir S. Katusic
Summary: The study revealed an age-related increase in APP expression in vascular endothelium, which is believed to be an adaptive response aimed at protecting and maintaining eNOS function. Endothelial dysfunction was exacerbated in aged eAPP(-/-) mice compared to age-matched WT mice, suggesting a crucial role of APP in controlling endothelial function during aging.