Mitochondrial dysfunction: A potential target for Alzheimer’s disease intervention and treatment
出版年份 2021 全文链接
标题
Mitochondrial dysfunction: A potential target for Alzheimer’s disease intervention and treatment
作者
关键词
Alzheimer’s disease, Mitochondrial dysfunction, Intervention, Treatment
出版物
DRUG DISCOVERY TODAY
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2021-05-05
DOI
10.1016/j.drudis.2021.04.025
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Mitochondrial dysfunction, insulin resistance and potential genetic implications
- (2020) Panjamaporn Sangwung et al. ENDOCRINOLOGY
- Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease
- (2020) Hui Zhou et al. BIOMATERIALS
- The role of mitochondrial impairment on Alzheimer´s disease neurodegeneration: the Tau connection
- (2020) Rodrigo A. Quntanilla et al. Current Neuropharmacology
- Impairment of PGC-1α-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease
- (2020) Monique Patricio Singulani et al. EXPERIMENTAL GERONTOLOGY
- Amyloid-β Causes Mitochondrial Dysfunction via a Ca2+-Driven Upregulation of Oxidative Phosphorylation and Superoxide Production in Cerebrovascular Endothelial Cells
- (2020) Dominic D. Quintana et al. JOURNAL OF ALZHEIMERS DISEASE
- Insulin mediated novel therapies for the treatment of Alzheimer's disease
- (2020) Sunil Kumar Dubey et al. LIFE SCIENCES
- Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer’s Disease
- (2020) Sachchida Nand Rai et al. MOLECULAR NEUROBIOLOGY
- Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances
- (2020) Wenzhang Wang et al. Molecular Neurodegeneration
- Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
- (2020) Kai Kaarniranta et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases
- (2020) Xixi Zhang et al. Aging-US
- Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function
- (2020) Zoe Arvanitakis et al. ANNALS OF NEUROLOGY
- Can nicotinamide riboside protect against cognitive impairment?
- (2020) Nady Braidy et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- Long-term oral melatonin alleviates memory deficits, reduces amyloid-β deposition associated with downregulation of BACE1 and mitophagy in APP/PS1 transgenic mice
- (2020) Cuimei Sun et al. NEUROSCIENCE LETTERS
- Mitochondrial dynamics in postmitotic cells regulate neurogenesis
- (2020) Ryohei Iwata et al. SCIENCE
- Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease
- (2020) D. Allan Butterfield et al. Antioxidants
- Curcumin Formulations and Trials: What’s New in Neurological Diseases
- (2020) Stella Gagliardi et al. MOLECULES
- Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome
- (2019) Fabio Di Domenico et al. Redox Biology
- Regulatory roles of miR-22/Redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury
- (2019) Zhonglong Liu et al. Cell Death & Disease
- Rapamycin and Alzheimer’s disease: Time for a clinical trial?
- (2019) Matt Kaeberlein et al. Science Translational Medicine
- Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease
- (2019) Evandro F. Fang et al. NATURE NEUROSCIENCE
- The role of mitochondrial defects and oxidative stress in Alzheimer’s disease
- (2019) Badar ul Islam et al. JOURNAL OF DRUG TARGETING
- ApoE4: an emerging therapeutic target for Alzheimer’s disease
- (2019) Mirna Safieh et al. BMC Medicine
- The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis?
- (2019) Pierre Dourlen et al. ACTA NEUROPATHOLOGICA
- Rapamycin and Alzheimer disease: a double-edged sword?
- (2019) Julian M Carosi et al. Autophagy
- Autophagy dysfunction in Alzheimer’s disease: mechanistic insights and new therapeutic opportunities
- (2019) Antonio Di Meco et al. BIOLOGICAL PSYCHIATRY
- Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View
- (2019) Giovanna Cenini et al. Oxidative Medicine and Cellular Longevity
- Mitochondrial dynamics and transport in Alzheimer's disease
- (2019) Padraig J. Flannery et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Mitochondria and the Brain: Bioenergetics and Beyond
- (2019) Pascale Belenguer et al. NEUROTOXICITY RESEARCH
- Alzheimer’s disease: Key developments support promising perspectives for therapy
- (2019) Jacopo Meldolesi PHARMACOLOGICAL RESEARCH
- mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
- (2019) Candice E. Van Skike et al. AGING CELL
- Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces Aβ levels in Alzheimer's disease models
- (2019) Zhan Zhang et al. AGING CELL
- Differential activation of the mTOR/autophagy pathway predicts cognitive performance in APP/PS1 mice
- (2019) Rasika S. Vartak et al. NEUROBIOLOGY OF AGING
- Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis
- (2019) Anushka Chakravorty et al. Frontiers in Aging Neuroscience
- Mitochondrial calcium signaling as a therapeutic target for Alzheimer’s disease
- (2019) Aston Jiaxi Wu et al. Current Alzheimer Research
- KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis
- (2019) Xu Qian et al. MOLECULAR CELL
- Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer’s Disease
- (2018) Qing Chen et al. ACS Nano
- The mitochondrial ATP synthase is a shared drug target for aging and dementia
- (2018) Joshua Goldberg et al. AGING CELL
- β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog–Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models
- (2018) Thomas Goiran et al. BIOLOGICAL PSYCHIATRY
- Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
- (2018) Steven E. Arnold et al. Nature Reviews Neurology
- Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease
- (2018) IsaacG Onyango Neural Regeneration Research
- Nutraceuticals: An emerging therapeutic approach against the pathogenesis of Alzheimer’s disease
- (2018) Pritam Sadhukhan et al. PHARMACOLOGICAL RESEARCH
- The Therapeutic Potential of Metformin in Neurodegenerative Diseases
- (2018) Carola Rotermund et al. Frontiers in Endocrinology
- Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives
- (2018) Gantumur Battogtokh et al. Acta Pharmaceutica Sinica B
- Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
- (2018) Masha G. Savelieff et al. CHEMICAL REVIEWS
- Mitogen-activated protein kinase phosphatase 1 protects PC12 cells from amyloid beta-induced neurotoxicity
- (2018) Xiao-Ping Li et al. Neural Regeneration Research
- Mitochondrial Pharmacology of Dimebon (Latrepirdine) Calls for a New Look at its Possible Therapeutic Potential in Alzheimer’s Disease
- (2018) Schamim H Eckert et al. Aging and Disease
- Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease
- (2018) María José Pérez et al. Redox Biology
- Accuracy and generalization capability of an automatic method for the detection of typical brain hypometabolism in prodromal Alzheimer disease
- (2018) Fabrizio De Carli et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Mitochondrial dynamics, a key executioner in neurodegenerative diseases
- (2018) Komal Panchal et al. MITOCHONDRION
- Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
- (2018) Antonella Tramutola et al. Translational Neurodegeneration
- Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial
- (2017) Suzanne Craft et al. JOURNAL OF ALZHEIMERS DISEASE
- Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
- (2017) Vincenzo Sorrentino et al. NATURE
- Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation
- (2017) Xin Liu et al. NATURE CELL BIOLOGY
- Resveratrol ameliorates spatial learning memory impairment induced by Aβ 1–42 in rats
- (2017) Rui Wang et al. NEUROSCIENCE
- Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms
- (2017) Jesse S. Kerr et al. TRENDS IN NEUROSCIENCES
- Therapeutic efficacy of the Ginkgo special extract EGb761® within the framework of the mitochondrial cascade hypothesis of Alzheimer’s disease
- (2017) Walter E. Müller et al. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
- Dimebon (Latrepirdine) Enhances Mitochondrial Function and Protects Neuronal Cells from Death
- (2017) Shouting Zhang et al. JOURNAL OF ALZHEIMERS DISEASE
- Pioglitazone prevents tau oligomerization
- (2016) Tadanori Hamano et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Progress in drug development for Alzheimer's disease: An overview in relation to mitochondrial energy metabolism
- (2016) Jana Hroudová et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Pioglitazone for the treatment of Alzheimer’s disease
- (2016) Daniela Galimberti et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Energy metabolism and inflammation in brain aging and Alzheimer’s disease
- (2016) Fei Yin et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer’s Disease
- (2016) Isaura V.A. Martins et al. JOURNAL OF ALZHEIMERS DISEASE
- Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors
- (2016) Rita Maria Concetta Di Martino et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Mitocentric View of Alzheimer’s Disease
- (2016) Hao Hu et al. MOLECULAR NEUROBIOLOGY
- Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity
- (2016) A.M. Bertholet et al. NEUROBIOLOGY OF DISEASE
- Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease
- (2016) Kalpita Banerjee et al. NEUROCHEMISTRY INTERNATIONAL
- Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease
- (2016) Tianfang Jiang et al. PROGRESS IN NEUROBIOLOGY
- Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
- (2016) Mohd Waseem Akhtar et al. Nature Communications
- Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility
- (2016) Omolola R. Oyenihi et al. Journal of Diabetes Research
- Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies
- (2016) Isaac G. Onyango et al. Aging and Disease
- Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease
- (2016) Zun-Jing Liu et al. Frontiers in Pharmacology
- A comprehensive multiomics approach toward understanding the relationship between aging and dementia
- (2015) Antonio Currais et al. Aging-US
- The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer's disease and mild-to-moderate Alzheimer's disease: a meta-analysis
- (2015) Huawei Cheng et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Long-Term Vitamin E-Deficient Mice Exhibit Cognitive Dysfunction via Elevation of Brain Oxidation
- (2015) Koji FUKUI et al. JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
- Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus
- (2015) Tahir Ali et al. JOURNAL OF PINEAL RESEARCH
- mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy
- (2015) Marzia Perluigi et al. NEUROBIOLOGY OF DISEASE
- Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s Disease
- (2015) Fabian A. Cabezas-Opazo et al. Oxidative Medicine and Cellular Longevity
- Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death
- (2015) Natascia Guida et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Efficacy ofGinkgo bilobaextract EGb 761®in dementia with behavioural and psychological symptoms: A systematic review
- (2015) Armin von Gunten et al. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
- Flavonoid-Based Therapies in the Early Management of Neurodegenerative Diseases
- (2015) Isha Solanki et al. Advances in Nutrition
- Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain
- (2014) D. Allan Butterfield et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mitochondrial genome maintenance in health and disease
- (2014) William C. Copeland et al. DNA REPAIR
- Mechanisms of action of brain insulin against neurodegenerative diseases
- (2014) Mahesh Ramalingam et al. JOURNAL OF NEURAL TRANSMISSION
- Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model
- (2014) Tahir Ali et al. JOURNAL OF PINEAL RESEARCH
- Disturbed mitochondrial dynamics and neurodegenerative disorders
- (2014) Florence Burté et al. Nature Reviews Neurology
- SIRT1 in Neurodevelopment and Brain Senescence
- (2014) A. Zara Herskovits et al. NEURON
- Insulin protects against Aβ-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption
- (2014) Rasoul Ghasemi et al. NEUROPHARMACOLOGY
- Targeting the Prodromal Stage of Alzheimer’s Disease: Bioenergetic and Mitochondrial Opportunities
- (2014) Charles C. Caldwell et al. Neurotherapeutics
- Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model
- (2013) John W. Steele et al. Autophagy
- Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model
- (2013) Hong Xie et al. JOURNAL OF NEUROSCIENCE
- Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy
- (2013) Chong Wang et al. MOLECULAR NEUROBIOLOGY
- Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases
- (2013) P R Bharadwaj et al. Translational Psychiatry
- Mitochondrial Dysfunction—A Pharmacological Target in Alzheimer's Disease
- (2012) Gunter P. Eckert et al. MOLECULAR NEUROBIOLOGY
- Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model
- (2012) J W Steele et al. MOLECULAR PSYCHIATRY
- Adult hippocampal neurogenesis and its role in Alzheimer's disease
- (2011) Yangling Mu et al. Molecular Neurodegeneration
- A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease
- (2011) Qi Chen et al. PLoS One
- The Puzzling Rise and Fall of a Dark-Horse Alzheimer's Drug
- (2010) G. Miller SCIENCE
- Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection
- (2009) Merce Pallas et al. CURRENT NEUROVASCULAR RESEARCH
- Diffusion tensor imaging in mild cognitive impairment and Alzheimerʼs disease: a review
- (2009) Terence C Chua et al. CURRENT OPINION IN NEUROLOGY
- AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol
- (2009) J.-H. Um et al. DIABETES
- Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease
- (2009) Tomohiko Sato et al. NEUROBIOLOGY OF AGING
- Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study
- (2008) Rachelle S Doody et al. LANCET
- Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
- (2008) Heng Du et al. NATURE MEDICINE
- Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI
- (2007) Clifford R. Jack et al. NEUROBIOLOGY OF AGING
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