mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
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Title
mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
Authors
Keywords
-
Journal
AGING CELL
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2019-11-07
DOI
10.1111/acel.13057
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- (2018) Ellen Kraig et al. EXPERIMENTAL GERONTOLOGY
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- (2017) Anna Csiszar et al. GeroScience
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- (2016) Lingxi Wang et al. EXPERIMENTAL NEUROLOGY
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- (2016) Daojing Li et al. FASEB JOURNAL
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- (2016) Xiang-Tao Zheng et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
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- (2015) Ai-Ling Lin et al. NEUROBIOLOGY OF AGING
- The age factor in Alzheimer’s disease
- (2015) Rita Guerreiro et al. Genome Medicine
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- (2014) J. B. Mannick et al. Science Translational Medicine
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- (2014) Joaquin N. Lugo et al. Frontiers in Molecular Neuroscience
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- Neurovascular coupling in normal aging: A combined optical, ERP and fMRI study
- (2013) Monica Fabiani et al. NEUROIMAGE
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- (2012) John E. Wilkinson et al. AGING CELL
- Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
- (2012) J. Halloran et al. NEUROSCIENCE
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- (2011) Naobumi Hamadate et al. BRAIN RESEARCH
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- (2011) Loredana Stoica et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2009) U. Schmitt et al. NEUROSCIENCE
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