Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia

(2018) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models

(2018) Chiara Lanzillotta et al.   JOURNAL OF ALZHEIMERS DISEASE

Poly-ubiquitin profile in Alzheimer disease brain

(2018) Antonella Tramutola et al.   NEUROBIOLOGY OF DISEASE

Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease

(2018) Eugenio Barone et al.   MOLECULAR NEUROBIOLOGY

Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome

(2017) Fiorenza Stagni et al.   NEUROBIOLOGY OF DISEASE

Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer’s disease

(2017) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice

(2016) Yan-Fang Mao et al.   AGING CELL

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

(2016) Antonella Tramutola et al.   Expert Review of Neurotherapeutics

Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

(2016) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Control of proteasomal proteolysis by mTOR

(2016) Jinghui Zhao et al.   NATURE

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

(2016) Antonella Tramutola et al.   Expert Review of Neurotherapeutics

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

(2015) Elizabeth Head et al.   Current Alzheimer Research

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

(2015) Arlan Richardson et al.   EXPERIMENTAL GERONTOLOGY

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

(2015) Frances K. Wiseman et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome

(2015) Andrea Giacomini et al.   NEUROBIOLOGY OF DISEASE

Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome

(2015) Yuniesky Andrade-Talavera et al.   NEUROBIOLOGY OF DISEASE

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

(2015) Marzia Perluigi et al.   NEUROBIOLOGY OF DISEASE

Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down's Syndrome

(2015) Antonella Tramutola et al.   Neurodegenerative Diseases

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

(2015) Robert Siman et al.   PLoS One

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

(2014) D. Allan Butterfield et al.   BIOCHEMICAL JOURNAL

Reduced numbers of switched memory B cells with high terminal differentiation potential in Down syndrome

(2014) Rita Carsetti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

(2014) Yanxing Chen et al.   EXPERIMENTAL NEUROLOGY

Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease

(2014) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Assessing Spatial Learning and Memory in Rodents

(2014) C. V. Vorhees et al.   ILAR JOURNAL

mTOR Hyperactivation in Down Syndrome Hippocampus Appears Early During Development

(2014) Anand M. Iyer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Prenatal pharmacotherapy rescues brain development in a Down’s syndrome mouse model

(2013) Sandra Guidi et al.   BRAIN

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis

(2013) Zhi Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

(2013) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: Insights from proteomics

(2013) Marzia Perluigi et al.   Proteomics Clinical Applications

Autophagic/lysosomal dysfunction in Alzheimer’s disease

(2013) Miranda E Orr et al.   Alzheimers Research & Therapy

Role of Tau Protein in Neuronal Damage in Alzheimer's Disease and Down Syndrome

(2012) Ana M. Cárdenas et al.   ARCHIVES OF MEDICAL RESEARCH

Chronic Expression of RCAN1-1L Protein Induces Mitochondrial Autophagy and Metabolic Shift from Oxidative Phosphorylation to Glycolysis in Neuronal Cells

(2012) Gennady Ermak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?

(2012) Zhiyou Cai et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Deregulated mTOR-mediated translation in intellectual disability

(2012) José Antonio Troca-Marín et al.   PROGRESS IN NEUROBIOLOGY

Intranasal delivery of biologics to the central nervous system

(2011) Jeffrey J. Lochhead et al.   ADVANCED DRUG DELIVERY REVIEWS

Infections and immunodeficiency in Down syndrome

(2011) G. Ram et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cross-Talk between AMPK and mTOR in Regulating Energy Balance

(2011) Jia Xu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Regulation of RCAN1 Protein Activity by Dyrk1A Protein-mediated Phosphorylation

(2011) Min-Su Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

(2011) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn

(2011) Laura G. Reinholdt et al.   MAMMALIAN GENOME

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Altered regulation of tau phosphorylation in a mouse model of down syndrome aging

(2011) Olivia Sheppard et al.   NEUROBIOLOGY OF AGING

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders

(2011) Zhao Zhong Chong et al.   Oxidative Medicine and Cellular Longevity

mTOR Signaling

(2011) M. Laplante et al.   Cold Spring Harbor Perspectives in Biology

One-trial object recognition in rats and mice: Methodological and theoretical issues

(2010) A. Ennaceur   BEHAVIOURAL BRAIN RESEARCH

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

(2010) Tao Yu et al.   HUMAN MOLECULAR GENETICS

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

β-Amyloid overload does not directly correlate with SAPK/JNK activation and tau protein phosphorylation in the cerebellar cortex of Ts65Dn mice

(2009) Selene Lomoio et al.   BRAIN RESEARCH

Intrinsic defect of the immune system in children with Down syndrome: a review

(2009) M. A. A. Kusters et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

(2009) D. Allan Butterfield et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Rapamycin Rescues TDP-43 Mislocalization and the Associated Low Molecular Mass Neurofilament Instability

(2009) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model

(2009) Jennifer H. K. Choi et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's-related endosome dysfunction in Down syndrome is A -independent but requires APP and is reversed by BACE-1 inhibition

(2009) Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Cell Cycle Elongation Impairs Proliferation of Cerebellar Granule Cell Precursors in the Ts65Dn Mouse, an Animal Model for Down Syndrome

(2008) Andrea Contestabile et al.   BRAIN PATHOLOGY

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

(2008) Fei Liu et al.   FASEB JOURNAL

Abnormal expression of synaptic proteins and neurotrophin-3 in the down syndrome mouse model Ts65Dn

(2008) G. Pollonini et al.   NEUROSCIENCE