Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway

Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas

(2016) Audrey Bouillez et al.   CANCER RESEARCH

The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target

(2016) Icard Philippe et al.   DRUG RESISTANCE UPDATES

Mucin 1-mediated chemo-resistance in lung cancer cells

(2016) S Y Ham et al.   Oncogenesis

Clinical significance of IGF1R gene expression in patients with Stage II/III gastric cancer who receive curative surgery and adjuvant chemotherapy with S-1

(2015) Koji Numata et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

Citrate Synthase Expression Affects Tumor Phenotype and Drug Resistance in Human Ovarian Carcinoma

(2014) Lilan Chen et al.   PLoS One

Expression of insulin-like growth factor receptor type 1 correlate with lymphatic metastases in human gastric cancer

(2014) Mariusz Gryko et al.   POLISH JOURNAL OF PATHOLOGY

MUC1: a multifaceted oncoprotein with a key role in cancer progression

(2014) Sritama Nath et al.   TRENDS IN MOLECULAR MEDICINE

Knockdown of Malic Enzyme 2 Suppresses Lung Tumor Growth, Induces Differentiation and Impacts PI3K/AKT Signaling

(2014) Jian-Guo Ren et al.   Scientific Reports

A critical role for citrate metabolism in LPS signalling

(2013) Luke A. J. O'Neill   BIOCHEMICAL JOURNAL

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

Spermine and Citrate as Metabolic Biomarkers for Assessing Prostate Cancer Aggressiveness

(2013) Guro F. Giskeødegård et al.   PLoS One

PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells

(2013) H Luo et al.   Cell Death & Disease

ATP citrate lyase knockdown impacts cancer stem cells in vitro

(2013) J-i Hanai et al.   Cell Death & Disease

Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells

(2013) Hubert Lincet et al.   Journal of Ovarian Research

Citrate kills tumor cells through activation of apical caspases

(2012) Björn Kruspig et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Small Interfering RNA Targeted to IGF-IR Delays Tumor Growth and Induces Proinflammatory Cytokines in a Mouse Breast Cancer Model

(2012) Tiphanie Durfort et al.   PLoS One

A model for cancer-suppressive inflammation

(2012) Ole Audun Werner Haabeth et al.   OncoImmunology

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways

(2011) Jun-ichi Hanai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Clinical report: A patient with primary peritoneal mesothelioma that has improved after taking citric acid orally

(2011) A.H. Bucay   Clinics and Research in Hepatology and Gastroenterology

High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy

(2010) B. C. Litzenburger et al.   CLINICAL CANCER RESEARCH

Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases?

(2010) T. J. Smith   PHARMACOLOGICAL REVIEWS

Induction of Erythroid Differentiation in Human Erythroleukemia Cells by Depletion of Malic Enzyme 2

(2010) Jian-Guo Ren et al.   PLoS One

Phase II Study of the Anti–Insulin-Like Growth Factor Type 1 Receptor Antibody CP-751,871 in Combination With Paclitaxel and Carboplatin in Previously Untreated, Locally Advanced, or Metastatic Non–Small-Cell Lung Cancer

(2009) Daniel D. Karp et al.   JOURNAL OF CLINICAL ONCOLOGY

Hypothesis proved…citric acid (citrate) does improve cancer: A case of a patient suffering from medullary thyroid cancer

(2009) Alberto Halabe Bucay   MEDICAL HYPOTHESES

High Expression Levels of Total IGF-1R and Sensitivity of NSCLC Cells In Vitro to an Anti-IGF-1R Antibody (R1507)

(2009) Yixuan Gong et al.   PLoS One

Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2  Phosphorylation Pathway

(2009) Z. Mounir et al.   Science Signaling

Insulin, insulin-like growth factors and neoplasia

(2008) Michael Pollak   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Targeting insulin and insulin-like growth factor signalling in oncology

(2008) Michael Pollak   CURRENT OPINION IN PHARMACOLOGY

Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis

(2008) R. Brooks Robey et al.   SEMINARS IN CANCER BIOLOGY