Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-03-18
DOI
10.3389/fonc.2020.00231
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma – MCT1 as potential target in diffuse large B cell lymphoma
- (2019) Julieta Afonso et al. CELLULAR ONCOLOGY
- Expression of Monocarboxylate Transporter 1 Is Associated With Better Prognosis and Reduced Nodal Metastasis in Pancreatic Ductal Adenocarcinoma
- (2019) Aoi Sukeda et al. PANCREAS
- Metabolic regulation of gene expression by histone lactylation
- (2019) Di Zhang et al. NATURE
- Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
- (2019) Karen G. de la Cruz-López et al. Frontiers in Oncology
- Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response
- (2019) Shamir Cassim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Colorectal cancer cell–derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway
- (2018) Guangyao Dai et al. BULLETIN DU CANCER
- Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
- (2018) Dhruv Kumar et al. CANCER RESEARCH
- Including the mitochondrial metabolism of l-lactate in cancer metabolic reprogramming
- (2018) Lidia de Bari et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma
- (2018) Yucheng Fu et al. MEDICINE
- The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma
- (2018) Damien Ambrosetti et al. PLoS One
- Monocarboxylate transporters MCT1 and MCT4 are independent prognostic biomarkers for the survival of patients with clear cell renal cell carcinoma and those receiving therapy targeting angiogenesis
- (2018) Yan-Wei Cao et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer
- (2018) Nikos Koundouros et al. Frontiers in Oncology
- Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
- (2018) Maria Apicella et al. Cell Metabolism
- Cancer-associated fibroblasts modify lung cancer metabolism involving ROS and TGF-β signaling
- (2018) Alberto Cruz-Bermúdez et al. FREE RADICAL BIOLOGY AND MEDICINE
- Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
- (2018) Toszka Bohn et al. NATURE IMMUNOLOGY
- Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
- (2018) Yangbo Feng et al. Cancer Medicine
- Lactate: A Metabolic Driver in the Tumour Landscape
- (2018) Luigi Ippolito et al. TRENDS IN BIOCHEMICAL SCIENCES
- Stromal-epithelial lactate shuttle induced by tumor‑derived interleukin‑1β promotes cell proliferation in oral squamous cell carcinoma
- (2017) Jie Wu et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance
- (2017) Jorge Burns et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metabolic cooperation between co-cultured lung cancer cells and lung fibroblasts
- (2017) Michael I Koukourakis et al. LABORATORY INVESTIGATION
- Monocarboxylate transporter 1 is a key player in glioma-endothelial cell crosstalk
- (2017) Vera Miranda-Gonçalves et al. MOLECULAR CARCINOGENESIS
- Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells
- (2017) J Feng et al. ONCOGENE
- Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism
- (2017) Tao Shan et al. ONCOLOGY REPORTS
- Lactic Acid: No Longer an Inert and End-Product of Glycolysis
- (2017) Shiren Sun et al. PHYSIOLOGY
- Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis
- (2017) Peiwen Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Value of pH regulators in the diagnosis, prognosis and treatment of cancer
- (2017) Sara Granja et al. SEMINARS IN CANCER BIOLOGY
- Mitochondrial and glycolytic metabolic compartmentalization in diffuse large B-cell lymphoma
- (2017) Mahasweta Gooptu et al. SEMINARS IN ONCOLOGY
- Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop
- (2017) Sensen Lin et al. Oncotarget
- Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors
- (2017) Vincent F. Van Hée et al. Oncotarget
- The Glycolytic Switch in Tumors: How Many Players Are Involved?
- (2017) Li Yu et al. Journal of Cancer
- Lactate Shuttles in Neuroenergetics—Homeostasis, Allostasis and Beyond
- (2017) Shayne Mason Frontiers in Neuroscience
- Strategies to Improve the Efficacy of Dendritic Cell-Based Immunotherapy for Melanoma
- (2017) Kristian M. Hargadon Frontiers in Immunology
- Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment
- (2017) Kathrin Renner et al. Frontiers in Immunology
- Metabolic zonation of the liver: The oxygen gradient revisited
- (2017) Thomas Kietzmann Redox Biology
- Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis
- (2017) Tieying Dong et al. Scientific Reports
- Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect
- (2016) Iñigo San-Millán et al. CARCINOGENESIS
- Prognostic significance of monocarboxylate transporter expression in oral cavity tumors
- (2016) Susana Simões-Sousa et al. CELL CYCLE
- The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4
- (2016) Céline Pinheiro et al. CELL CYCLE
- In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons
- (2016) Philipp Mächler et al. Cell Metabolism
- Lactate at the crossroads of metabolism, inflammation, and autoimmunity
- (2016) Valentina Pucino et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Proteomics Unveils Fibroblast–Cardiomyocyte Lactate Shuttle and Hexokinase Paradox in Mouse Muscles
- (2016) Dariusz Rakus et al. JOURNAL OF PROTEOME RESEARCH
- Proteomic identification of the lactate dehydrogenase A in a radioresistant prostate cancer xenograft mouse model for improving radiotherapy
- (2016) Jingli Hao et al. Oncotarget
- G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion
- (2016) Yu Jin Lee et al. Oncotarget
- Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling
- (2016) Elizabeth Allen et al. Cell Reports
- Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
- (2016) Hongyun Zhao et al. eLife
- Prognostic Role of Lactate Dehydrogenase Expression in Urologic Cancers: A Systematic Review and Meta-Analysis
- (2016) Yong Zhang et al. Oncology Research and Treatment
- Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance
- (2016) Susana Romero-Garcia et al. Frontiers in Immunology
- Prognostic role of lactate dehydrogenase in solid tumors: A systematic review and meta-analysis of 76 studies
- (2015) Fausto Petrelli et al. ACTA ONCOLOGICA
- A Lactate-Induced Response to Hypoxia
- (2015) Dong Chul Lee et al. CELL
- L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation
- (2015) Waldemar Wagner et al. Cell Communication and Signaling
- Metabolic coupling in urothelial bladder cancer compartments and its correlation to tumor aggressiveness
- (2015) Julieta Afonso et al. CELL CYCLE
- Lactate promotes glutamine uptake and metabolism in oxidative cancer cells
- (2015) Jhudit Pérez-Escuredo et al. CELL CYCLE
- Expression of lactate/H+ symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses
- (2015) Younghye Kim et al. HUMAN PATHOLOGY
- Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners
- (2015) Takashi Muramatsu JOURNAL OF BIOCHEMISTRY
- Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy
- (2015) Ru-Juan Zuo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hyperpolarized 13C NMR observation of lactate kinetics in skeletal muscle
- (2015) J. M. Park et al. JOURNAL OF EXPERIMENTAL BIOLOGY
- Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
- (2015) Céline Pinheiro et al. Oncotarget
- Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread
- (2015) Elisa Giannoni et al. Oncotarget
- Bladder cancer cells re-educate TAMs through lactate shuttling in the microfluidic cancer microenvironment
- (2015) Yang Zhao et al. Oncotarget
- Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
- (2015) Robert Haas et al. PLOS BIOLOGY
- Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis
- (2015) Cory D. Bovenzi et al. Biomed Research International
- Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions
- (2015) Clovis S. Palmer et al. Frontiers in Immunology
- A Pilot Proteogenomic Study with Data Integration Identifies MCT1 and GLUT1 as Prognostic Markers in Lung Adenocarcinoma
- (2015) Paul A. Stewart et al. PLoS One
- Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status
- (2015) Sara Granja et al. Oncotarget
- Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome
- (2014) J. Doyen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer
- (2014) Nelma Pértega-Gomes et al. BMC CANCER
- Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival
- (2014) C. L. Roland et al. CANCER RESEARCH
- FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression
- (2014) J. Cui et al. CLINICAL CANCER RESEARCH
- Monocarboxylate transporter 4 predicts poor prognosis in hepatocellular carcinoma and is associated with cell proliferation and migration
- (2014) Heng-Jun Gao et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway
- (2014) H. Shime et al. JOURNAL OF IMMUNOLOGY
- CD147 and MCT1-potential partners in bladder cancer aggressiveness and cisplatin resistance
- (2014) Julieta Afonso et al. MOLECULAR CARCINOGENESIS
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- β2-Adrenergic receptors protect axons during energetic stress but do not influence basal glio-axonal lactate shuttling in mouse white matter
- (2014) G. Laureys et al. NEUROSCIENCE
- Synergistic Anti-Cancer Effect of Phenformin and Oxamate
- (2014) W. Keith Miskimins et al. PLoS One
- Monocarboxylate Transporters 1–4 in NSCLC: MCT1 Is an Independent Prognostic Marker for Survival
- (2014) Marte Eilertsen et al. PLoS One
- Prognostic Significance of Lactate/Proton Symporters MCT1, MCT4, and Their Chaperone CD147 Expressions in Urothelial Carcinoma of the Bladder
- (2014) Jung-Woo Choi et al. UROLOGY
- Characterization of monocarboxylate transporter activity in hepatocellular carcinoma
- (2014) Venâncio A Alves WORLD JOURNAL OF GASTROENTEROLOGY
- Acidity Generated by the Tumor Microenvironment Drives Local Invasion
- (2013) V. Estrella et al. CANCER RESEARCH
- Cancer metabolism, stemness and tumor recurrence
- (2013) Joseph M. Curry et al. CELL CYCLE
- Monocarboxylate Transporters 1 and 4 Are Associated with CD147 in Cervical Carcinoma
- (2013) Céline Pinheiro et al. DISEASE MARKERS
- Etiology and Therapeutic Approach to Elevated Lactate Levels
- (2013) Lars W. Andersen et al. MAYO CLINIC PROCEEDINGS
- The SLC16 gene family – Structure, role and regulation in health and disease
- (2013) Andrew P. Halestrap MOLECULAR ASPECTS OF MEDICINE
- Reverse Warburg Effect in a Patient With Aggressive B-Cell Lymphoma: Is Lactic Acidosis a Paraneoplastic Syndrome?
- (2013) Ubaldo E. Martinez-Outschoorn et al. SEMINARS IN ONCOLOGY
- Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells
- (2013) Yefei Rong et al. TUMOR BIOLOGY
- Importance of glycolysis and oxidative phosphorylation in advanced melanoma
- (2012) Jonhan Ho et al. Molecular Cancer
- Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets
- (2012) Vera Miranda-Gonçalves et al. NEURO-ONCOLOGY
- Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
- (2012) Pierre Sonveaux et al. PLoS One
- LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma
- (2012) Feng Yao et al. TUMOR BIOLOGY
- Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
- (2011) Sophia Y. Lunt et al. Annual Review of Cell and Developmental Biology
- Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer
- (2011) Nelma Pértega-Gomes et al. BMC CANCER
- Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis
- (2011) F. Vegran et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
- (2011) Stephanos Pavlides et al. CELL CYCLE
- Cellular expression of monocarboxylate transporters in the female reproductive organ of mice: implications for the genital lactate shuttle
- (2011) Takuya Kuchiiwa et al. HISTOCHEMISTRY AND CELL BIOLOGY
- Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation
- (2011) Anna N. Mendler et al. INTERNATIONAL JOURNAL OF CANCER
- Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release
- (2011) Kristina Goetze INTERNATIONAL JOURNAL OF ONCOLOGY
- Brain Lactate Metabolism: The Discoveries and the Controversies
- (2011) Gerald A Dienel JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Synthesis of cytochrome c oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death
- (2011) C Wanka et al. ONCOGENE
- Adipose Tissue Lipolysis Revisited (Again!): Lactate Involvement in Insulin Antilipolytic Action
- (2010) Dominique Langin Cell Metabolism
- Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression
- (2010) Hongmin Chen et al. CLINICAL & EXPERIMENTAL METASTASIS
- Lactate-Dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1
- (2010) Gian Kayser et al. Diagnostic Pathology
- Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma
- (2010) Céline Pinheiro et al. HISTOPATHOLOGY
- HIF-1: upstream and downstream of cancer metabolism
- (2009) Gregg L Semenza CURRENT OPINION IN GENETICS & DEVELOPMENT
- The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer
- (2009) Céline Pinheiro et al. EUROPEAN JOURNAL OF CANCER
- CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models
- (2009) W Schneiderhan et al. GUT
- Metabolic Enzymes as Oncogenes or Tumor Suppressors
- (2009) Craig B. Thompson NEW ENGLAND JOURNAL OF MEDICINE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse γ-Hydroxybutyric Acid
- (2008) Marilyn E. Morris et al. AAPS Journal
- Tumor Cell Metabolism: Cancer's Achilles' Heel
- (2008) Guido Kroemer et al. CANCER CELL
- Increasing Expression of Monocarboxylate Transporters 1 and 4 Along Progression to Invasive Cervical Carcinoma
- (2008) Céline Pinheiro et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
- Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81
- (2008) Changlu Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
- (2008) Pierre Sonveaux et al. JOURNAL OF CLINICAL INVESTIGATION
- Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas
- (2008) Céline Pinheiro et al. VIRCHOWS ARCHIV
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation