Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases

The aspartyl asparaginyl beta-hydroxylase in carcinomas

(2015) Hui Yang   Frontiers in Bioscience-Landmark

Mutations in ASPH Cause Facial Dysmorphism, Lens Dislocation, Anterior-Segment Abnormalities, and Spontaneous Filtering Blebs, or Traboulsi Syndrome

(2014) Nisha Patel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structure and Functional Analysis of YcfD, a Novel 2-Oxoglutarate/Fe2+-Dependent Oxygenase Involved in Translational Regulation in Escherichia coli

(2014) Laura M. van Staalduinen et al.   JOURNAL OF MOLECULAR BIOLOGY

Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1

(2014) Tianshu Feng et al.   MOLECULAR CELL

Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine–serine-rich (RS) domains of SR- and SR-like proteins

(2014) Astrid Heim et al.   NUCLEIC ACIDS RESEARCH

Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth

(2014) M. J. Katz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

(2014) John S. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

(2014) R. S. Singleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

(2014) C. Loenarz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is JmjC Oxygenase Catalysis Limited to Demethylation?

(2013) Richard J. Hopkinson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Substrate Selectivity Analyses of Factor Inhibiting Hypoxia-Inducible Factor

(2013) Ming Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization

(2013) Alexander Wolf et al.   BIOCHEMICAL JOURNAL

Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release

(2013) Wen Liu et al.   CELL

Lysyl 5-Hydroxylation, a Novel Histone Modification, by Jumonji Domain Containing 6 (JMJD6)

(2013) Motoko Unoki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of human histone and nucleic acid demethylases

(2012) Louise J Walport et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

(2012) WeiShen Aik et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

(2012) Wei Ge et al.   Nature Chemical Biology

Lys34 of translation elongation factor EF-P is hydroxylated by YfcM

(2012) Lauri Peil et al.   Nature Chemical Biology

Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes

(2012) Brian W. Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lysine methylation: beyond histones

(2011) Xi Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The 2-Oxoglutarate-Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S-Hydroxylysine Residues

(2011) Monica Mantri et al.   CHEMBIOCHEM

Inhibition of 2-oxoglutarate dependent oxygenases

(2011) Nathan R. Rose et al.   CHEMICAL SOCIETY REVIEWS

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

(2011) Ming Yang et al.   FEBS Journal

Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation

(2011) Rachelle S. Singleton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

(2011) Ya-Min Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1

(2011) J.-N. Boeckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6

(2011) Monica Mantri et al.   MedChemComm

The AlkB Domain of Mammalian ABH8 Catalyzes Hydroxylation of 5-Methoxycarbonylmethyluridine at the Wobble Position of tRNA

(2010) Ye Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model

(2010) Bernhard Schmierer et al.   BMC Systems Biology

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

(2010) Lin Yan et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

(2010) Emily Flashman et al.   FEBS Journal

Prolyl 3-Hydroxylase 1 Null Mice Display Abnormalities in Fibrillar Collagen-rich Tissues Such as Tendons, Skin, and Bones

(2010) Janice A. Vranka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expanding Role of the Jumonji C Domain as an RNA Hydroxylase

(2010) Akiko Noma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor

(2010) Ming Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of JMJD6 with single-stranded RNA

(2010) X. Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

(2010) Christoph Loenarz et al.   TRENDS IN BIOCHEMICAL SCIENCES

FIH-Dependent Asparaginyl Hydroxylation of Ankyrin Repeat Domain-Containing Proteins

(2009) Matthew E. Cockman et al.   Annals of the New York Academy of Sciences

A cytoplasmic prolyl hydroxylation and glycosylation pathway modifies Skp1 and regulates O2-dependent development in Dictyostelium

(2009) Christopher M. West et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase

(2009) Krishna M Sinha et al.   EMBO JOURNAL

Differences in hydroxylation and binding of Notch and HIF-1α demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1)

(2009) Sarah E. Wilkins et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Location of 3-Hydroxyproline Residues in Collagen Types I, II, III, and V/XI Implies a Role in Fibril Supramolecular Assembly

(2009) Mary Ann Weis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asparaginyl β-Hydroxylation of Proteins Containing Ankyrin Repeat Domains Influences Their Stability and Function

(2009) Adam P. Hardy et al.   JOURNAL OF MOLECULAR BIOLOGY

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

(2009) John R Horton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Sulfilimine Bond Identified in Collagen IV

(2009) R. Vanacore et al.   SCIENCE

Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

(2009) Celia J. Webby et al.   SCIENCE

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

(2009) Rasheduzzaman Chowdhury et al.   STRUCTURE

Oxygen homeostasis

(2009) Gregg L. Semenza   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL