The redox requirements of proliferating mammalian cells

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes

(2017) Benjamin A. Olenchock et al.   IMMUNITY

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

(2017) Vinay Bulusu et al.   Cell Reports

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

(2016) Jonathan L. Coloff et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

The importance of serine metabolism in cancer

(2016) Katherine R. Mattaini et al.   JOURNAL OF CELL BIOLOGY

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage

(2016) Ling Liu et al.   Nature Chemical Biology

In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD+/NADH redox state

(2016) Yuzheng Zhao et al.   Nature Protocols

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

(2016) D. V. Titov et al.   SCIENCE

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

(2016) Xiaoyan Robert Bao et al.   eLife

Serine one-carbon catabolism with formate overflow

(2016) J. Meiser et al.   Science Advances

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Famine versus feast: understanding the metabolism of tumors in vivo

(2015) Jared R. Mayers et al.   TRENDS IN BIOCHEMICAL SCIENCES

Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides

(2015) Wei Liu et al.   Scientific Reports

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

(2014) Caroline A. Lewis et al.   MOLECULAR CELL

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

(2014) J. Ye et al.   Cancer Discovery

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

(2014) Christiaan F. Labuschagne et al.   Cell Reports

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

(2013) J. Fan et al.   Molecular Systems Biology

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids

(2013) Nousheen Zaidi et al.   PROGRESS IN LIPID RESEARCH

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

(2013) Sarah-Maria Fendt et al.   Nature Communications

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

(2013) Katherine M. Aird et al.   Cell Reports

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network

(2012) Guillaume Thibault et al.   MOLECULAR CELL

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

The Proline Regulatory Axis and Cancer

(2012) James Ming Phang et al.   Frontiers in Oncology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Organization and Lipid Rafts

(2011) K. Simons et al.   Cold Spring Harbor Perspectives in Biology

Modulation of human lymphocyte proliferation by amino acids

(2010) J. C. CHUANG et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Quiescent Fibroblasts Exhibit High Metabolic Activity

(2010) Johanna M. S. Lemons et al.   PLOS BIOLOGY

Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass Spectrometry

(2009) A. Hirayama et al.   CANCER RESEARCH

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL