Downstream processing for influenza vaccines and candidates: An update

Next-generation influenza vaccines: opportunities and challenges

(2020) Chih-Jen Wei et al.   NATURE REVIEWS DRUG DISCOVERY

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

(2020) Abishek Wadhwa et al.   Pharmaceutics

Polysaccharide-based chromatographic adsorbents for virus purification and viral clearance

(2020) Guy-Alain Junter et al.   Journal of Pharmaceutical Analysis

Next-Generation Influenza Vaccines

(2020) Masaru Kanekiyo et al.   Cold Spring Harbor Perspectives in Medicine

A Replication-Defective Influenza Virus Vaccine Confers Complete Protection against H7N9 Viral Infection in Mice

(2020) Shelby Landreth et al.   Vaccines

Engineered Nanoparticle Applications for Recombinant Influenza Vaccines

(2020) Zachary R Sia et al.   MOLECULAR PHARMACEUTICS

3D-printed ordered bed structures for chromatographic purification of enveloped and non-enveloped viral particles

(2020) Mafalda G. Moleirinho et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Novel Approaches for The Development of Live Attenuated Influenza Vaccines

(2019) Pilar Blanco-Lobo et al.   Viruses-Basel

Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections

(2019) Yung-Chieh Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane‐based approach for the downstream processing of influenza virus‐like particles

(2019) Sofia B. Carvalho et al.   Biotechnology Journal

Data-driven digital twin technology for optimized control in process systems

(2019) Rui He et al.   ISA TRANSACTIONS

Safety and immunogenicity of a replication-deficient H5N1 influenza virus vaccine lacking NS1

(2019) Christina Nicolodi et al.   VACCINE

mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials

(2019) Robert A. Feldman et al.   VACCINE

Efficient filtration strategies for the clarification of influenza virus-like particles derived from insect cells

(2019) Sofia B. Carvalho et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine

(2019) Kenta Matsuda et al.   Science Immunology

Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial

(2019) Cristina Carter et al.   PLoS One

Production and characterization of virus-like particles of grapevine fanleaf virus presenting L2 epitope of human papillomavirus minor capsid protein

(2019) Razieh Yazdani et al.   BMC BIOTECHNOLOGY

Current challenges in biotherapeutic particles manufacturing

(2019) Mafalda G. Moleirinho et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Live-attenuated H1N1 influenza vaccine candidate displays potent efficacy in mice and ferrets

(2019) Charles B. Stauft et al.   PLoS One

Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”

(2019) Felipe Tapia et al.   PLoS One

Exosome-based therapeutics: Purification using semi-continuous multi-column chromatography

(2019) Mafalda G. Moleirinho et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Development of Universal Influenza Vaccines Targeting Conserved Viral Proteins

(2019) Jazayeri et al.   Vaccines

Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives

(2019) Helena Bigares Grangeia et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Advances in influenza virus-like particles bioprocesses

(2019) Laurent Durous et al.   Expert Review of Vaccines

Nanoparticle vaccines against viral infections

(2018) Fernando B. Sulczewski et al.   ARCHIVES OF VIROLOGY

Induction of Cross-Clade Antibody and T-Cell Responses by a Modified Vaccinia Virus Ankara–Based Influenza A(H5N1) Vaccine in a Randomized Phase 1/2a Clinical Trial

(2018) Rory D de Vries et al.   JOURNAL OF INFECTIOUS DISEASES

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Improved Titers against Influenza Drift Variants with a Nanoparticle Vaccine

(2018) Vivek Shinde et al.   NEW ENGLAND JOURNAL OF MEDICINE

Broad cross-protective anti-hemagglutination responses elicited by influenza microconsensus DNA vaccine

(2018) Jian Yan et al.   VACCINE

Purification of cell culture-derived influenza A virus via continuous anion exchange chromatography on monoliths

(2018) Laura M. Fischer et al.   VACCINE

Combining stable insect cell lines with baculovirus-mediated expression for multi-HA influenza VLP production

(2018) Daniela P. Sequeira et al.   VACCINE

A fast and efficient purification platform for cell-based influenza viruses by flow-through chromatography

(2018) Yu-Fen Tseng et al.   VACCINE

Affinity chromatography for vaccines manufacturing: Finally ready for prime time?

(2018) Mochao Zhao et al.   VACCINE

Novel influenza vaccine M2SR protects against drifted H1N1 and H3N2 influenza virus challenge in ferrets with pre-existing immunity

(2018) Yasuko Hatta et al.   VACCINE

Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses

(2018) Lei Deng et al.   Nature Communications

A Review of DNA Vaccines Against Influenza

(2018) Leo Yi Yang Lee et al.   Frontiers in Immunology

Influenza

(2018) Florian Krammer et al.   Nature Reviews Disease Primers

Heterologous Two-Dose Vaccination with Simian Adenovirus and Poxvirus Vectors Elicits Long-Lasting Cellular Immunity to Influenza Virus A in Healthy Adults

(2018) L. Coughlan et al.   EBioMedicine

A Synthetic Micro-Consensus DNA Vaccine Generates Comprehensive Influenza A H3N2 Immunity and Protects Mice Against Lethal Challenge by Multiple H3N2 Viruses

(2018) Sarah T.C. Elliott et al.   HUMAN GENE THERAPY

3D-Printed Stationary Phases with Ordered Morphology: State of the Art and Future Development in Liquid Chromatography

(2018) Christopher Salmean et al.   CHROMATOGRAPHIA

Universal influenza vaccines: from viruses to nanoparticles

(2018) Ye Wang et al.   Expert Review of Vaccines

DNA vaccine priming for seasonal influenza vaccine in children and adolescents 6 to 17 years of age: A phase 1 randomized clinical trial

(2018) Katherine V. Houser et al.   PLoS One

Influenza vaccine: Where are we and where do we go?

(2018) Mohsen Keshavarz et al.   REVIEWS IN MEDICAL VIROLOGY

Optimization of cell culture-derived influenza A virus particles purification using sulfated cellulose membrane adsorbers

(2017) Ana Raquel Fortuna et al.   ENGINEERING IN LIFE SCIENCES

Purification of influenza virus-like particles using sulfated cellulose membrane adsorbers

(2017) Sofia B Carvalho et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Steric exclusion chromatography for purification of cell culture-derived influenza A virus using regenerated cellulose membranes and polyethylene glycol

(2017) Pavel Marichal-Gallardo et al.   JOURNAL OF CHROMATOGRAPHY A

Evaluating the immunogenicity and safety of a BiondVax-developed universal influenza vaccine (Multimeric-001) either as a standalone vaccine or as a primer to H5N1 influenza vaccine

(2017) Eva van Doorn et al.   MEDICINE

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

(2017) Kapil Bahl et al.   MOLECULAR THERAPY

Novel hemagglutinin nanoparticle influenza vaccine with Matrix-M™ adjuvant induces hemagglutination inhibition, neutralizing, and protective responses in ferrets against homologous and drifted A(H3N2) subtypes

(2017) Gale Smith et al.   VACCINE

Back to the future: Immunization with M-001 prior to trivalent influenza vaccine in 2011/12 enhanced protective immune responses against 2014/15 epidemic strain

(2017) George H. Lowell et al.   VACCINE

M2SR, a novel live influenza vaccine, protects mice and ferrets against highly pathogenic avian influenza

(2017) Yasuko Hatta et al.   VACCINE

High-Throughput Automation in Chemical Process Development

(2017) Joshua A. Selekman et al.   Annual Review of Chemical and Biomolecular Engineering

Universal label-free in-process quantification of influenza virus-like particles

(2017) Sofia B. Carvalho et al.   Biotechnology Journal

An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial

(2017) Adam D. DeZure et al.   npj Vaccines

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

(2017) Raffael Nachbagauer et al.   npj Vaccines

Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles

(2016) Sofia B. Carvalho et al.   BIOCONJUGATE CHEMISTRY

Clarification of vaccines: An overview of filter based technology trends and best practices

(2016) Lise Besnard et al.   BIOTECHNOLOGY ADVANCES

A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults

(2016) Stéphane Pillet et al.   CLINICAL IMMUNOLOGY

Progress in developing virus-like particle influenza vaccines

(2016) Fu-Shi Quan et al.   Expert Review of Vaccines

A membrane-based purification process for cell culture-derived influenza A virus

(2016) Thomas Weigel et al.   JOURNAL OF BIOTECHNOLOGY

Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge

(2016) Diletta Magini et al.   PLoS One

Activation of cross-reactive mucosal T and B cell responses in human nasopharynx-associated lymphoid tissue in vitro by Modified Vaccinia Ankara-vectored influenza vaccines

(2016) Jennifer Mullin et al.   VACCINE

M2SR, a novel live single replication influenza virus vaccine, provides effective heterosubtypic protection in mice

(2016) Sally Sarawar et al.   VACCINE

Novel universal influenza virus vaccine approaches

(2016) Florian Krammer   Current Opinion in Virology

Viral vector-based influenza vaccines

(2016) Rory D. de Vries et al.   Human Vaccines & Immunotherapeutics

Comparison of Membrane Chromatography and Monolith Chromatography for Lactoferrin and Bovine Serum Albumin Separation

(2016) Chalore Teepakorn et al.   Processes

Antibody Persistence in Adults Two Years after Vaccination with an H1N1 2009 Pandemic Influenza Virus-Like Particle Vaccine

(2016) Nuriban Valero-Pacheco et al.   PLoS One

Improved virus purification processes for vaccines and gene therapy

(2015) Piergiuseppe Nestola et al.   BIOTECHNOLOGY AND BIOENGINEERING

Next generation vaccines and vectors: Designing downstream processes for recombinant protein-based virus-like particles

(2015) Christopher Ladd Effio et al.   Biotechnology Journal

Critical assessment of influenza VLP production in Sf9 and HEK293 expression systems

(2015) Christine M Thompson et al.   BMC BIOTECHNOLOGY

A Synthetic Influenza Virus Vaccine Induces a Cellular Immune Response That Correlates with Reduction in Symptomatology and Virus Shedding in a Randomized Phase Ib Live-Virus Challenge in Humans

(2015) Olga Pleguezuelos et al.   Clinical and Vaccine Immunology

Phase I clinical evaluation of seasonal influenza hemagglutinin (HA) DNA vaccine prime followed by trivalent influenza inactivated vaccine (IIV3) boost

(2015) Julie E. Ledgerwood et al.   Contemporary Clinical Trials

Influenza Plasmid DNA Vaccines: Progress and Prospects

(2015) Diana Bicho et al.   CURRENT GENE THERAPY

Current and next generation influenza vaccines: Formulation and production strategies

(2015) Peter C. Soema et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Enveloped virus-like particle platforms: vaccines of the future?

(2015) Fabien Pitoiset et al.   Expert Review of Vaccines

Flucelvax (Optaflu) for seasonal influenza

(2015) Ilaria Manini et al.   Expert Review of Vaccines

Robust design of adenovirus purification by two-column, simulated moving-bed, size-exclusion chromatography

(2015) Piergiuseppe Nestola et al.   JOURNAL OF BIOTECHNOLOGY

Rational development of two flowthrough purification strategies for adenovirus type 5 and retro virus-like particles

(2015) Piergiuseppe Nestola et al.   JOURNAL OF CHROMATOGRAPHY A

Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin

(2015) Michela Brazzoli et al.   JOURNAL OF VIROLOGY

High titre neutralising antibodies to influenza after oral tablet immunisation: a phase 1, randomised, placebo-controlled trial

(2015) David Liebowitz et al.   LANCET INFECTIOUS DISEASES

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Phase 1 Study of Pandemic H1 DNA Vaccine in Healthy Adults

(2015) Michelle C. Crank et al.   PLoS One

DNA Priming for Seasonal Influenza Vaccine: A Phase 1b Double-Blind Randomized Clinical Trial

(2015) Julie E. Ledgerwood et al.   PLoS One

Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9) virus infection in ferrets

(2015) Ye V. Liu et al.   VACCINE

Inhibition of influenza H5N1 invasion by modified heparin derivatives

(2015) Mark A. Skidmore et al.   MedChemComm

Downstream processing and chromatography based analytical methods for production of vaccines, gene therapy vectors, and bacteriophages

(2015) Petra Kramberger et al.   Human Vaccines & Immunotherapeutics

Current and Emerging Cell Culture Manufacturing Technologies for Influenza Vaccines

(2015) Ernest Milián et al.   Biomed Research International

Next generation vaccines and vectors: Designing downstream processes for recombinant protein-based virus-like particles

(2015) Christopher Ladd Effio et al.   Biotechnology Journal

Dramatic Decline of Respiratory Illness Among US Military Recruits After the Renewed Use of Adenovirus Vaccines

(2014) J. M. Radin et al.   CLINICAL INFECTIOUS DISEASES

Production and purification of plasmid DNA vaccines: is there scope for further innovation?

(2014) Alex Xenopoulos et al.   Expert Review of Vaccines

Epitope-based approaches to a universal influenza vaccine

(2014) Tanya Gottlieb et al.   JOURNAL OF AUTOIMMUNITY

Adenovirus purification by two-column, size-exclusion, simulated countercurrent chromatography

(2014) Piergiuseppe Nestola et al.   JOURNAL OF CHROMATOGRAPHY A

3D printed porous media columns with fine control of column packing morphology

(2014) Conan Fee et al.   JOURNAL OF CHROMATOGRAPHY A

A flow-through chromatography process for influenza A and B virus purification

(2014) Thomas Weigel et al.   JOURNAL OF VIROLOGICAL METHODS

Safety and immunogenicity of a modified-vaccinia-virus-Ankara-based influenza A H5N1 vaccine: a randomised, double-blind phase 1/2a clinical trial

(2014) Joost H C M Kreijtz et al.   LANCET INFECTIOUS DISEASES

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

(2014) Joanna Kowalska et al.   NUCLEIC ACIDS RESEARCH

Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections

(2014) J.-R. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine

(2014) Jian Yan et al.   VACCINE

Purification of Vero cell derived live replication deficient influenza A and B virus by ion exchange monolith chromatography

(2014) Marko Banjac et al.   VACCINE

The Split Virus Influenza Vaccine rapidly activates immune cells through Fcγ receptors

(2014) William E. O’Gorman et al.   VACCINE

Priming by a novel universal influenza vaccine (Multimeric-001)—A gateway for improving immune response in the elderly population

(2014) Jacob Atsmon et al.   VACCINE

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: Results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers

(2014) Jenny G.H. Low et al.   VACCINE

Virus-Vectored Influenza Virus Vaccines

(2014) Ralph Tripp et al.   Viruses-Basel

Clarification of recombinant proteins from high cell density mammalian cell culture systems using new improved depth filters

(2013) Nripen Singh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Process cost and facility considerations in the selection of primary cell culture clarification technology

(2013) Michael Felo et al.   BIOTECHNOLOGY PROGRESS

Traditional and New Influenza Vaccines

(2013) S.-S. Wong et al.   CLINICAL MICROBIOLOGY REVIEWS

Continuous purification of influenza virus using simulated moving bed chromatography

(2013) T. Kröber et al.   JOURNAL OF CHROMATOGRAPHY A

Prime-Boost Interval Matters: A Randomized Phase 1 Study to Identify the Minimum Interval Necessary to Observe the H5 DNA Influenza Vaccine Priming Effect

(2013) Julie E. Ledgerwood, Kathryn Zephir, Zonghui Hu, Chih-Jen Wei, LeeJah Chang, Mary E. Enama, Cynthia S. Hendel, Sandra Sitar, Robert T. Bailer, Richard A. Koup, John R. Mascola, Gary J. Nabel, Barney S. Graham et al.   JOURNAL OF INFECTIOUS DISEASES

H3 Stalk-Based Chimeric Hemagglutinin Influenza Virus Constructs Protect Mice from H7N9 Challenge

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Safety and immunogenicity of an oral, replicating adenovirus serotype 4 vector vaccine for H5N1 influenza: a randomised, double-blind, placebo-controlled, phase 1 study

(2013) Marc Gurwith et al.   LANCET INFECTIOUS DISEASES

Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens

(2013) Richard D Antrobus et al.   MOLECULAR THERAPY

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

(2013) Masaru Kanekiyo et al.   NATURE

A Recombinant Viruslike Particle Influenza A (H7N9) Vaccine

(2013) Louis F. Fries et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice

(2013) Chen Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Generation of Influenza Vaccine Viruses for Rapid Response to Pandemics

(2013) P. R. Dormitzer et al.   Science Translational Medicine

RNA: The new revolution in nucleic acid vaccines

(2013) Andrew J. Geall et al.   SEMINARS IN IMMUNOLOGY

Virus-like particle-based human vaccines: quality assessment based on structural and functional properties

(2013) Qinjian Zhao et al.   TRENDS IN BIOTECHNOLOGY

Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-γ T cell responses in humans

(2013) Wendy Peters et al.   VACCINE

Phase I/II trial of a replication-deficient trivalent influenza virus vaccine lacking NS1

(2013) Christina Mössler et al.   VACCINE

Development of influenza H7N9 virus like particle (VLP) vaccine: Homologous A/Anhui/1/2013 (H7N9) protection and heterologous A/chicken/Jalisco/CPA1/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus

(2013) Gale E. Smith et al.   VACCINE

Analytical technologies for influenza virus-like particle candidate vaccines: challenges and emerging approaches

(2013) Christine M Thompson et al.   Virology Journal

Soft sensors in bioprocessing: A status report and recommendations

(2012) Reiner Luttmann et al.   Biotechnology Journal

Periodic counter-current chromatography - design and operational considerations for integrated and continuous purification of proteins

(2012) Rahul Godawat et al.   Biotechnology Journal

An Adenovirus-Based Vaccine with a Double-Stranded RNA Adjuvant Protects Mice and Ferrets against H5N1 Avian Influenza in Oral Delivery Models

(2012) Ciaran D. Scallan et al.   Clinical and Vaccine Immunology

Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans

(2012) Patrick J. Lillie et al.   CLINICAL INFECTIOUS DISEASES

Safety and Immunogenicity of Multimeric-001—a Novel Universal Influenza Vaccine

(2012) Jacob Atsmon et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Purification of human and avian influenza viruses using cellulose sulfate ester (Cellufine Sulfate) in the process of vaccine production

(2012) Yoshihiro Sakoda et al.   MICROBIOLOGY AND IMMUNOLOGY

Immunization with a Hemagglutinin-Derived Synthetic Peptide Formulated with a CpG-DNA-Liposome Complex Induced Protection against Lethal Influenza Virus Infection in Mice

(2012) Jae Won Rhee et al.   PLoS One

A T Cell-Inducing Influenza Vaccine for the Elderly: Safety and Immunogenicity of MVA-NP+M1 in Adults Aged over 50 Years

(2012) Richard D. Antrobus et al.   PLoS One

Synthetic Influenza vaccine (FLU-v) stimulates cell mediated immunity in a double-blind, randomised, placebo-controlled Phase I trial

(2012) Olga Pleguezuelos et al.   VACCINE

Downstream processing of cell culture-derived virus particles

(2011) Michael W Wolf et al.   Expert Review of Vaccines

ISCOM technology-based Matrix M™ adjuvant: success in future vaccines relies on formulation

(2011) Karin Lövgren Bengtsson et al.   Expert Review of Vaccines

A fast track influenza virus vaccine produced in insect cells

(2011) Manon M.J. Cox et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials

(2011) Julie E Ledgerwood et al.   LANCET INFECTIOUS DISEASES

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico

(2011) Constantino López-Macías et al.   VACCINE

Purification of cell culture-derived modified vaccinia ankara virus by pseudo-affinity membrane adsorbers and hydrophobic interaction chromatography

(2010) Michael W. Wolff et al.   BIOTECHNOLOGY AND BIOENGINEERING

Isoelectric points of viruses

(2010) B. Michen et al.   JOURNAL OF APPLIED MICROBIOLOGY

Live attenuated influenza virus vaccines by computer-aided rational design

(2010) Steffen Mueller et al.   NATURE BIOTECHNOLOGY

Phase 1 clinical trials of the safety and immunogenicity of adjuvanted plasmid DNA vaccines encoding influenza A virus H5 hemagglutinin

(2010) Larry R. Smith et al.   VACCINE

Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design

(2010) Emily M. Plummer et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Sulfated membrane adsorbers for economic pseudo-affinity capture of influenza virus particles

(2009) Lars Opitz et al.   BIOTECHNOLOGY AND BIOENGINEERING

Trivalent MDCK cell culture-derived influenza vaccine Optaflu®(Novartis Vaccines)

(2009) Alexander Doroshenko et al.   Expert Review of Vaccines

Preclinical Evaluation of a Replication-Deficient Intranasal ΔNS1 H5N1 Influenza Vaccine

(2009) Julia Romanova et al.   PLoS One

Glycans on influenza hemagglutinin affect receptor binding and immune response

(2009) C.-C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of pharmaceutical-grade plasmids at high concentration and high supercoiled percentage

(2009) Ying Cai et al.   VACCINE

Influenza vaccines based on virus-like particles

(2009) Sang-Moo Kang et al.   VIRUS RESEARCH

Downstream Processing: From Egg to Cell Culture-Derived Influenza Virus Particles

(2008) M. W. Wolff et al.   CHEMICAL ENGINEERING & TECHNOLOGY

FluBlok, a recombinant hemagglutinin influenza vaccine

(2008) Manon M.J. Cox et al.   Influenza and Other Respiratory Viruses

Simulated moving bed chromatography for the separation of enantiomers

(2008) Arvind Rajendran et al.   JOURNAL OF CHROMATOGRAPHY A

Tangential flow filtration for virus purification

(2008) David L. Grzenia et al.   JOURNAL OF MEMBRANE SCIENCE

Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies

(2008) Marina De Filette et al.   VACCINE