Analytical technologies for influenza virus-like particle candidate vaccines: challenges and emerging approaches

A VLP Vaccine Induces Broad-Spectrum Cross-Protective Antibody Immunity against H5N1 and H1N1 Subtypes of Influenza A Virus

(2012) Chia-Ying Wu et al.   PLoS One

Residual Baculovirus in Insect Cell-Derived Influenza Virus-Like Particle Preparations Enhances Immunogenicity

(2012) Irina Margine et al.   PLoS One

Production and characterization of mammalian virus-like particles from modified vaccinia virus Ankara vectors expressing influenza H5N1 hemagglutinin and neuraminidase

(2012) Falko Schmeisser et al.   VACCINE

Simultaneous quantification of the viral antigens hemagglutinin and neuraminidase in influenza vaccines by LC–MSE

(2012) Marybeth C. Creskey et al.   VACCINE

One-step assay for detecting influenza virus using dynamic light scattering and gold nanoparticles

(2011) Jeremy D. Driskell et al.   ANALYST

Metabolic and Kinetic analyses of influenza production in perfusion HEK293 cell culture

(2011) Emma Petiot et al.   BMC BIOTECHNOLOGY

A Contributing Role for Anti-Neuraminidase Antibodies on Immunity to Pandemic H1N1 2009 Influenza A Virus

(2011) Glendie Marcelin et al.   PLoS One

Physical analysis of virus particles using electrospray differential mobility analysis

(2011) Leonard F. Pease   TRENDS IN BIOTECHNOLOGY

Optimization and qualification of a quantitative reversed-phase HPLC method for hemagglutinin in influenza preparations and its comparative evaluation with biochemical assays

(2011) Barry Lorbetskie et al.   VACCINE

Influenza virus-like particle can accommodate multiple subtypes of hemagglutinin and protect from multiple influenza types and subtypes

(2011) Peter Pushko et al.   VACCINE

Baculovirus-Produced Influenza Virus-like Particles in Mammalian Cells Protect Mice from Lethal Influenza Challenge

(2011) Xian-Chun Tang et al.   VIRAL IMMUNOLOGY

Improved particle counting and size distribution determination of aggregated virus populations by asymmetric flow field-flow fractionation and multiangle light scattering techniques

(2010) Matt McEvoy et al.   BIOTECHNOLOGY PROGRESS

Trichoplusia ni cells (High FiveTM) are highly efficient for the production of influenza A virus-like particles: a comparison of two insect cell lines as production platforms for influenza vaccines

(2010) Florian Krammer et al.   MOLECULAR BIOTECHNOLOGY

The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza

(2010) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Mammalian Expression of Virus-Like Particles for Advanced Mimicry of Authentic Influenza Virus

(2010) Chia-Ying Wu et al.   PLoS One

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Hemagglutinin Displayed Baculovirus Protects Against Highly Pathogenic Influenza

(2010) Xian-Chun Tang et al.   VACCINE

Qualitative and quantitative analyses of virtually all subtypes of influenza A and B viral neuraminidases using antibodies targeting the universally conserved sequences

(2010) Caroline Gravel et al.   VACCINE

Dynamic Light Scattering as a Powerful Tool for Gold Nanoparticle Bioconjugation and Biomolecular Binding Studies

(2009) Hilde Jans et al.   ANALYTICAL CHEMISTRY

Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge

(2009) Zhiyuan Wen et al.   ANTIVIRAL RESEARCH

Swine-origin pandemic H1N1 influenza virus-like particles produced in insect cells induce hemagglutination inhibiting antibodies in BALB/c mice

(2009) Florian Krammer et al.   Biotechnology Journal

DNA Vaccination with a Single‐Plasmid Construct Coding for Viruslike Particles Protects Mice against Infection with a Highly Pathogenic Avian Influenza A Virus

(2009) Judit Szécsi et al.   JOURNAL OF INFECTIOUS DISEASES

Novel swine-origin influenza A virus in humans: another pandemic knocking at the door

(2009) Martin Michaelis et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

A simple slot blot for the detection of virtually all subtypes of the influenza A viral hemagglutinins using universal antibodies targeting the fusion peptide

(2009) Changgui Li et al.   Nature Protocols

Induction of Long-Term Protective Immune Responses by Influenza H5N1 Virus-Like Particles

(2009) Sang-Moo Kang et al.   PLoS One

Out of Mexico? Scientists Ponder Swine Flu's Origins

(2009) J. Cohen   SCIENCE

A novel assay for influenza virus quantification using surface plasmon resonance

(2009) C. Estmer Nilsson et al.   VACCINE

Influenza vaccines based on virus-like particles

(2009) Sang-Moo Kang et al.   VIRUS RESEARCH

Monitoring of influenza virus hemagglutinin in process samples using weak affinity ligands and surface plasmon resonance

(2008) Carl-Fredrik Mandenius et al.   ANALYTICA CHIMICA ACTA

Characterization of virus-like particle assembly for DNA delivery using asymmetrical flow field-flow fractionation and light scattering

(2008) Andrzej Citkowicz et al.   ANALYTICAL BIOCHEMISTRY

Gold Nanoparticle-Based Colorimetric Assay for the Direct Detection of Cancerous Cells

(2008) Colin D. Medley et al.   ANALYTICAL CHEMISTRY

Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy

(2008) Leonard F. Pease et al.   BIOTECHNOLOGY AND BIOENGINEERING

Influenza virus-like particles produced by transient expression inNicotiana benthamianainduce a protective immune response against a lethal viral challenge in mice

(2008) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins

(2008) Stella Chun et al.   VACCINE

H5N1 VLP vaccine induced protection in ferrets against lethal challenge with highly pathogenic H5N1 influenza viruses

(2008) Kutubuddin Mahmood et al.   VACCINE

A bivalent influenza VLP vaccine confers complete inhibition of virus replication in lungs

(2008) Fu Shi Quan et al.   VACCINE

Quantification of influenza virus hemagglutinins in complex mixtures using isotope dilution tandem mass spectrometry

(2008) Tracie L. Williams et al.   VACCINE

HPLC-based quantification of haemagglutinin in the production of egg- and MDCK cell-derived influenza virus seasonal and pandemic vaccines

(2008) J.C. Kapteyn et al.   VACCINE

Monitoring influenza virus content in vaccine production: Precise assays for the quantitation of hemagglutination and neuraminidase activity

(2007) Bernd Kalbfuss et al.   BIOLOGICALS