Article
Immunology
Alissa Cait, Anna Mooney, Hazel Poyntz, Nick Shortt, Angela Jones, Aurelie Gestin, Katie Gell, Alix Grooby, David O'Sullivan, Jeffry S. Tang, Wayne Young, Darmiga Thayabaran, Jenny Sparks, Tess Ostapowicz, Audrey Tay, Sally D. Poppitt, Sarah Elliott, Georgia Wakefield, Amber Parry-Strong, Jacqui Ralston, Richard Beasley, Mark Weatherall, Irene Braithwaite, Elizabeth Forbes-Blom, Olivier Gasser
Summary: Research suggests that dietary fiber may have a significant impact on humoral vaccine responses, with fiber intake positively correlated with immune responses in vaccinees, while prior influenza vaccination negatively impacts immunogenicity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Elias Tjarnhage, Diamond Brown, Bjarne Bogen, Tor Kristian Andersen, Gunnveig Grodeland
Summary: This article introduces a viral subunit vaccine that maintains the trimeric form and targets antigen-presenting cells for increased immunogenicity. The vaccine induces strong immune responses and protects mice from lethal challenges with influenza viruses.
JOURNAL OF VIROLOGY
(2023)
Article
Cell Biology
Leoni Rolfes, Steffen Pfeuffer, Jelena Skuljec, Xia He, Chuanxin Su, Sinem-Hilal Oezalp, Marc Pawlitzki, Tobias Ruck, Melanie Korsen, Konstanze Kleinschnitz, Derya Aslan, Tim Hagenacker, Christoph Kleinschnitz, Sven G. Meuth, Refik Pul
Summary: Cladribine-treated MS patients can mount an adequate immune response to influenza independently of treatment duration and time interval to the last cladribine administration. The antibody response against influenza A was comparable between cladribine-treated patients and controls, while the response against influenza B was lower in the cladribine cohort. The increase in geometric mean titers was also lower in the cladribine group compared to controls, but titers increased in both groups for all strains.
Article
Immunology
Huy Quang Quach, Krista M. Goergen, Diane E. Grill, Iana H. Haralambieva, Inna G. Ovsyannikova, Gregory A. Poland, Richard B. Kennedy
Summary: This study identified shared gene expression pathways in response to influenza and vaccinia virus stimulation in different immune cells. The immune response signaling pathways identified can be targeted for the development of broad therapeutics and vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Tor Kristian Andersen, Johanna Bodin, Fredrik Oftung, Bjarne Bogen, Siri Mjaaland, Gunnveig Grodeland
Summary: The 2009 swine flu pandemic exposed the limitations of egg-based vaccines in terms of global supply, prompting the urgent need for efficient new vaccine platforms; DNA vaccines have since been developed as a temperature stable, cost-effective option for pandemic responses, capable of inducing rapid protective immune responses without the need for adjuvants.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hiroaki Kato, Takao Hozawa, Wakaba Fukushima, Eri Nobusawa, Yoshio Hirota
Summary: The Ministry of Health, Labour and Welfare in Japan designates specific virus strains for the seasonal influenza vaccine and domestic manufacturers produce vaccines with the same formulation. The focus has been on the antigenic match between the vaccine strains and epidemic viruses. However, in 2017, the selection system had issues with vaccine productivity, leading to reforms in 2018. A symposium was held to discuss vaccine virus selection, evaluation, and new formulation efforts in Japan.
Article
Multidisciplinary Sciences
Vijaykrishna Dhanasekaran, Sheena Sullivan, Kimberly M. Edwards, Ruopeng Xie, Arseniy Khvorov, Sophie A. Valkenburg, Benjamin J. Cowling, Ian G. Barr
Summary: Since the onset of the COVID-19 pandemic, public health measures and travel restrictions have heavily suppressed global influenza circulation. The genetic diversity of seasonal influenza viruses has significantly decreased, with the influenza B/Yamagata lineage not conclusively detected. Travel restrictions have confined the circulation of different influenza viruses to specific regions, leading to a continuous decline in global transmission of seasonal influenza, except in select hotspots that may seed future epidemics. Additionally, the selection of influenza vaccine strains and epidemic control face challenges due to waning population immunity and sporadic case detection.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Zhaozhen Liu, Can Pang, Yuchuan Deng, Caiping Guo, Jia Li, Yanping Li, Ruolei Xin, Xiyao Li, Conghui Xu, Chun Huang, Hongyan Lu, Jie Li
Summary: This study investigated the immunogenicity of the quadrivalent inactivated influenza vaccine in HIV-infected and uninfected individuals, and found that HIV-infected individuals had weaker immune responses, especially those with CD4+ T cell counts below 350 cells/mm3.
Review
Immunology
Brenda L. Coleman, Iris Gutmanis, Ian Mcgovern, Mendel Haag
Summary: Cell-based quadrivalent influenza vaccine (QIVc) shows higher effectiveness compared to egg-based options. The effectiveness of QIVc varies among different age groups in seasonal influenza vaccination.
Article
Pharmacology & Pharmacy
Mathilde Bausart, Kevin Vanvarenberg, Bernard Ucakar, Alessandra Lopes, Gaelle Vandermeulen, Alessio Malfanti, Veronique Preat
Summary: Combining DNA vaccines and dual immune checkpoint blockade can enhance the immune response in glioblastoma and improve the immune landscape in an unresectable GBM model. The combination therapy increases the ratio of effector T cells to Tregs in the spleens and the frequency of IFN-γ-secreting CD8 T cells in the brains.
Article
Immunology
Yan-Yang Tao, Jing-Xin Li, Yue-Mei Hu, Yuan-Sheng Hu, Gang Zeng, Feng-Cai Zhu
Summary: The Quadrivalent Influenza Vaccine containing two A and two B strains showed comparable immunogenicity and safety profiles to trivalent vaccines for shared strains. The addition of a second B strain to the trivalent vaccine could induce superior immune responses for the alternate B strain, making it a cost-effective strategy for global influenza prevention.
EXPERT REVIEW OF VACCINES
(2021)
Article
Immunology
Zhu Guo, Xiuhua Lu, Paul J. Carney, Jessie Chang, Wen-pin Tzeng, Ian A. York, Min Z. Levine, James Stevens
Summary: In this study, a biolayer interferometry (BLI)-based assay was used to determine the dominant binding epitopes of the globular head domain of influenza virus surface protein hemagglutinin (HA1) in antibody response to influenza vaccines. Results showed that several mutated HA1 exhibited more than 50% reduction in BLI binding compared to the wild type, and there was a strong correlation between dominant residues identified by the BLI and hemagglutination inhibition (HI) assays. This study provides a systematic method for analyzing antibody immunodominance in the humoral response to influenza vaccines.
Review
Immunology
Irina Isakova-Sivak, Ekaterina Stepanova, Daria Mezhenskaya, Victoria Matyushenko, Polina Prokopenko, Ivan Sychev, Pei-Fong Wong, Larisa Rudenko
Summary: Current research has focused on improving antibody responses to conserved B cell epitopes and inducing T cells recognizing highly conserved viral epitopes for universal influenza vaccines. The development of T cell-based universal influenza vaccines is challenging due to factors such as the diversity of MHCs in the population and the lack of adequate animal models. Vaccines that elicit significant levels of T cells recognizing conserved epitopes possess high cross-protective potential against circulating influenza viruses.
EXPERT REVIEW OF VACCINES
(2021)
Article
Immunology
Amnah Siddiqa, Yating Wang, Maheshwor Thapa, Dominique E. Martin, Andreia N. Cadar, Jenna M. Bartley, Shuzhao Li
Summary: Many human diseases, including metabolic diseases, have connections with the immune system. However, the understanding of how the human immune system interacts with pharmaceutical drugs is limited, and there is a lack of epidemiological studies in this area. With the advancement of metabolomics technology, it is now possible to measure drug metabolites and biological responses in the same global profiling data, offering a new opportunity to study drug-immune system interactions. This study demonstrates the use of metabolomics to investigate drug interaction with the immune response in human samples directly at the molecular level.
Article
Immunology
Malembe S. Ebama, Susan Y. Chu, Eduardo Azziz-Baumgartner, Kathryn E. Lafond, Margaret McCarron, Stephen C. Hadler, Rachael M. Porter, Mark McKinlay, Joseph Bresee
Summary: Implementing seasonal influenza vaccines not only reduces diseases but also improves attitudes towards vaccines among risk groups, increases demand, and enhances collaboration with other sectors and mass media. However, challenges such as sustaining investment, vaccine supply, and campaign management still exist.
Article
Immunology
Takuya Yamamoto, Yuji Masuta, Masatoshi Momota, Masaru Kanekiyo, Tomohiro Kanuma, Shoukichi Takahama, Eiko Moriishi, Yasuhiro Yasutomi, Takashi Saito, Barney S. Graham, Yoshimasa Takahashi, Ken J. Ishii
INTERNATIONAL IMMUNOLOGY
(2019)
Article
Immunology
Nicolas Cuburu, Rina Kim, Geoffrey C. Guittard, Cynthia D. Thompson, Patricia M. Day, David E. Hamm, Yuk-Ying S. Pang, Barney S. Graham, Douglas R. Lowy, John T. Schiller
JOURNAL OF IMMUNOLOGY
(2019)
Article
Virology
Hannah Kleine-Weber, Mahmoud Tarek Elzayat, Lingshu Wang, Barney S. Graham, Marcel A. Mueller, Christian Drosten, Stefan Poehlmann, Markus Hoffmann
JOURNAL OF VIROLOGY
(2019)
Article
Medicine, General & Internal
Martin R. Gaudinski, Emily E. Coates, Laura Novik, Alicia Widge, Katherine V. Houser, Eugeania Burch, LaSonji A. Holman, Ingelise J. Gordon, Grace L. Chen, Cristina Carter, Martha Nason, Sandra Sitar, Galina Yamshchikov, Nina Berkowitz, Charla Andrews, Sandra Vazquez, Carolyn Laurencot, John Misasi, Frank Arnold, Kevin Carlton, Heather Lawlor, Jason Gall, Robert T. Bailer, Adrian McDermott, Edmund Capparelli, Richard A. Koup, John R. Mascola, Barney S. Graham, Nancy J. Sullivan, Julie E. Ledgerwood
Article
Immunology
Masaru Kanekiyo, M. Gordon Joyce, Rebecca A. Gillespie, John R. Gallagher, Sarah F. Andrews, Hadi M. Yassine, Adam K. Wheatley, Brian E. Fisher, David R. Ambrozak, Adrian Creanga, Kwanyee Leung, Eun Sung Yang, Seyhan Boyoglu-Barnum, Ivelin S. Georgiev, Yaroslav Tsybovsky, Madhu S. Prabhakaran, Hanne Andersen, Wing-Pui Kong, Ulrich Baxa, Kathryn L. Zephir, Julie E. Ledgerwood, Richard A. Koup, Peter D. Kwong, Audray K. Harris, Adrian B. McDermott, John R. Mascola, Barney S. Graham
Article
Virology
Danielle R. Adney, Lingshu Wang, Neeltje van Doremalen, Wei Shi, Yi Zhang, Wing-Pui Kong, Megan R. Miller, Trenton Bushmaker, Dana Scott, Emmie de Wit, Kayvon Modjarrad, Nikolai Petrovsky, Barney S. Graham, Richard A. Bowen, Vincent J. Munster
Article
Microbiology
Kizzmekia S. Corbett, Syed M. Moin, Hadi M. Yassine, Alberto Cagigi, Masaru Kanekiyo, Seyhan Boyoglu-Barnum, Sky I. Myers, Yaroslav Tsybovsky, Adam K. Wheatley, Chaim A. Schramm, Rebecca A. Gillespie, Wei Shi, Lingshu Wang, Yi Zhang, Sarah F. Andrews, M. Gordon Joyce, Michelle C. Crank, Daniel C. Douek, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Jeffrey C. Boyington
Article
Biochemistry & Molecular Biology
Fabian Sesterhenn, Marie Galloux, Sabrina S. Vollers, Lucia Csepregi, Che Yang, Delphyne Descamps, Jaume Bonet, Simon Friedensohn, Pablo Gainza, Patricia Corthesy, Man Chen, Stephane Rosset, Marie-Anne Rameix-Welti, Jean-Francois Eleouet, Sai T. Reddy, Barney S. Graham, Sabine Riffault, Bruno E. Correia
Article
Immunology
Reham A. Al Kahlout, Gheyath K. Nasrallah, Elmoubasher A. Farag, Lingshu Wang, Erik Lattwein, Marcel A. Mueller, Mohamed E. El Zowalaty, Hamad E. Al Romaihi, Barney S. Graham, Asmaa A. Al Thani, Hadi M. Yassine
JOURNAL OF IMMUNOLOGY RESEARCH
(2019)
Article
Immunology
Sarah F. Andrews, Michael J. Chambers, Chaim A. Schramm, Jason Plyler, Julie E. Raab, Masaru Kanekiyo, Rebecca A. Gillespie, Amy Ransier, Sam Darko, Jianfei Hu, Xuejun Chen, Hadi M. Yassine, Jeffrey C. Boyington, Michelle C. Crank, Grace L. Chen, Emily Coates, John R. Mascola, Daniel C. Douek, Barney S. Graham, Julie E. Ledgerwood, Adrian B. McDermott
Article
Multidisciplinary Sciences
Michelle C. Crank, Tracy J. Ruckwardt, Man Chen, Kaitlyn M. Morabito, Emily Phung, Pamela J. Costner, LaSonji A. Holman, Somia P. Hickman, Nina M. Berkowitz, Ingelise J. Gordon, Galina V. Yamshchikov, Martin R. Gaudinski, Azad Kumar, Lauren A. Chang, Syed M. Moin, Juliane P. Hill, Anthony T. DiPiazza, Richard M. Schwartz, Lisa Kueltzo, Jonathan W. Cooper, Peifeng Chen, Judith A. Stein, Kevin Carlton, Jason G. Gall, Martha C. Nason, Peter D. Kwong, Grace L. Chen, John R. Mascola, Jason S. McLellan, Julie E. Ledgerwood, Barney S. Graham
Review
Immunology
Tracy J. Ruckwardt, Kaitlyn M. Morabito, Barney S. Graham
Article
Immunology
Martin R. Gaudinski, Katherine V. Houser, Nicole A. Doria-Rose, Grace L. Chen, Ro Shauna S. Rothwell, Nina Berkowitz, Pamela Costner, LaSonji A. Holman, Ingelise J. Gordon, Cynthia S. Hendel, Florence Kaltovich, Michelle Conan-Cibotti, Margarita Gomez Lorenzo, Cristina Carter, Sandra Sitar, Kevin Carlton, Jason Gall, Carolyn Laurencot, Bob C. Lin, Robert T. Bailer, Adrian B. McDermott, Sung-Youl Ko, Amarendra Pegu, Young D. Kwon, Peter D. Kwong, Aryan M. Namboodiri, Janardan P. Pandey, Richard Schwartz, Frank Arnold, Zonghui Hu, Lily Zhang, Yunda Huang, Richard A. Koup, Edmund V. Capparelli, Barney S. Graham, John R. Mascola, Julie E. Ledgerwood, Floreliz Mendoza, Laura Novik, Kathy Zephir, William Whalen, Brenda Larkin, Jamie Saunders, Jennifer Cunningham, Carol Levinson, Xiaolin Wang, Sarah Plummer, Milalynn Victorino, Abidemi Ola, Catina Boyd, Nilusha Jayasinghe, Preeti Apte, Cora Trelles Cartagena, Renunda Hicks, Pernell Williams, Olga Vasilenko, Galina Yamshchikov, Maria Burgos Florez, Iris Pittman, Lucio Gama, Joseph Casazza, Hope DeCederfelt, K. C. Cheng, Judy Stein
Meeting Abstract
Immunology
G. Chen, E. Coates, C. Fichtenbaum, S. Koletar, R. Landovitz, R. Presti, T. Overton, J. Santana, R. S. Rothwel, J. Roa, E. Donaghy, L. Holman, L. Novik, N. Berkowitz, B. Larkin, M. Conan-Cibotti, R. Tressler, J. Wang, Z. Hu, E. Capparelli, F. Arnold, R. Bailer, A. McDermott, L. Gama, B. Graham, R. Koup, J. Mascola, J. Ledgerwood, P. Tebas
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2019)
Article
Immunology
Emily Phung, Lauren A. Chang, Kaitlyn M. Morabito, Masaru Kanekiyo, Man Chen, Deepika Nair, Azad Kumar, Grace L. Chen, Julie E. Ledgerwood, Barney S. Graham, Tracy J. Ruckwardt
Article
Medicine, Research & Experimental
Hongjin Li, Judith M. Schlaeger, Crystal L. Patil, Oana Danciu, Zhengjia Chen, Natalie Lif, Shuang Gao, Ardith Z. Doorenbos
Summary: Nearly 94% of breast cancer survivors experience symptoms or side effects during or after endocrine therapy, and acupuncture offers a comprehensive solution to address these issues. However, medically underserved breast cancer survivors often lack access to acupuncture. To promote equal access and evidence-based treatment, a randomized controlled trial is being conducted to investigate the effectiveness of acupuncture for symptom management among this population.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
JoAnn M. Sperl-Hillen, Jacob L. Haapala, Steven P. Dehmer, Lilian N. Chumba, Heidi L. Ekstrom, Anjali R. Truitt, Stephen E. Asche, Ann M. Werner, Dan J. Rehrauer, Melissa A. Pankonin, Pamala A. Pawloski, Patrick J. O'Connor
Summary: This article describes the original and adapted protocols of a randomized trial to improve medication adherence for cardiometabolic conditions. Protocol adaptation became imperative in response to major implementation challenges.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
Connor Celum, Bethany Jablonski Horton, Mark Conaway
Summary: This paper proposes a phase-I clinical trial design that uses ordinal toxicity to locate group-specific doses. The proposed method avoids dose-reversals and is compared with two other methods through simulations.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
Tanya Knutzen, Eileen Bulger, Matt Iles-Shih, Alexandra Hernandez, Allison Engstrom, Lauren Whiteside, Navneet Birk, Khadija Abu, Jake Shoyer, Cristina Conde, Paige Ryan, Jin Wang, Joan Russo, Patrick Heagerty, Larry Palinkas, Douglas Zatzick
Summary: This study aims to investigate how trauma centers in the US can effectively conduct mental health screening, intervention, and referral services to help injured patients recover. The study will randomly assign patients to different intervention groups and compare the impact of different interventions on PTSD symptoms and emergency department/inpatient utilization.
CONTEMPORARY CLINICAL TRIALS
(2024)