Advances in influenza virus-like particles bioprocesses

Towards a universal influenza vaccine: different approaches for one goal

(2018) Giuseppe A. Sautto et al.   Virology Journal

Universal Vaccines and Vaccine Platforms to Protect against Influenza Viruses in Humans and Agriculture

(2018) Daniela S. Rajão et al.   Frontiers in Microbiology

Separation of HIV-1 gag virus-like particles from vesicular particles impurities by hydroxyl-functionalized monoliths

(2017) Petra Steppert et al.   JOURNAL OF SEPARATION SCIENCE

Process intensification for high yield production of influenza H1N1 Gag virus-like particles using an inducible HEK-293 stable cell line

(2017) Alina Venereo-Sanchez et al.   VACCINE

Broadened immunity and protective responses with emulsion-adjuvanted H5 COBRA-VLP vaccines

(2017) James D. Allen et al.   VACCINE

Virus-like particles displaying H5, H7, H9 hemagglutinins and N1 neuraminidase elicit protective immunity to heterologous avian influenza viruses in chickens

(2017) Peter Pushko et al.   VIROLOGY

A novel H6N1 virus-like particle vaccine induces long-lasting cross-clade antibody immunity against human and avian H6N1 viruses

(2016) Ji-Rong Yang et al.   ANTIVIRAL RESEARCH

The role of host cell physiology in the productivity of the baculovirus-insect cell system: Fluxome analysis of Trichoplusia ni and Spodoptera frugiperda cell lines

(2016) Francisca Monteiro et al.   BIOTECHNOLOGY AND BIOENGINEERING

A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults

(2016) Stéphane Pillet et al.   CLINICAL IMMUNOLOGY

Progress in developing virus-like particle influenza vaccines

(2016) Fu-Shi Quan et al.   Expert Review of Vaccines

Targeted supplementation design for improved production and quality of enveloped viral particles in insect cell-baculovirus expression system

(2016) Francisca Monteiro et al.   JOURNAL OF BIOTECHNOLOGY

Modeling and simulation of anion-exchange membrane chromatography for purification of Sf9 insect cell-derived virus-like particles

(2016) Christopher Ladd Effio et al.   JOURNAL OF CHROMATOGRAPHY A

Purification of HIV-1 gag virus-like particles and separation of other extracellular particles

(2016) Petra Steppert et al.   JOURNAL OF CHROMATOGRAPHY A

Identification of Essential Genetic Baculoviral Elements for Recombinant Protein Expression by Transactivation in Sf21 Insect Cells

(2016) Maren Bleckmann et al.   PLoS One

Hemagglutinin and neuraminidase containing virus-like particles produced in HEK-293 suspension culture: An effective influenza vaccine candidate

(2016) Alina Venereo-Sanchez et al.   VACCINE

Preparation of quadri-subtype influenza virus-like particles using bovine immunodeficiency virus gag protein

(2016) Irina Tretyakova et al.   VIROLOGY

Intranasal Immunization with Influenza Virus-Like Particles Containing Membrane-Anchored Cholera Toxin B or Ricin Toxin B Enhances Adaptive Immune Responses and Protection against an Antigenically Distinct Virus

(2016) Xianliang Ji et al.   Viruses-Basel

Antibody Persistence in Adults Two Years after Vaccination with an H1N1 2009 Pandemic Influenza Virus-Like Particle Vaccine

(2016) Nuriban Valero-Pacheco et al.   PLoS One

Production of influenza virus-like particles from stably transfected Trichoplusia ni BT1 TN-5B1-4 cells

(2015) Geun Pyo Hong et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Modulating secretory pathway pH by proton channel co-expression can increase recombinant protein stability in plants

(2015) Philippe V. Jutras et al.   Biotechnology Journal

Next generation vaccines and vectors: Designing downstream processes for recombinant protein-based virus-like particles

(2015) Christopher Ladd Effio et al.   Biotechnology Journal

Critical assessment of influenza VLP production in Sf9 and HEK293 expression systems

(2015) Christine M Thompson et al.   BMC BIOTECHNOLOGY

A simple plasmid-based transient gene expression method using High Five cells

(2015) Xiao Shen et al.   JOURNAL OF BIOTECHNOLOGY

Structural Analysis of the Roles of Influenza A Virus Membrane-Associated Proteins in Assembly and Morphology

(2015) Petr Chlanda et al.   JOURNAL OF VIROLOGY

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Development of EV71 virus-like particle purification processes

(2015) Shih-Yeh Lin et al.   VACCINE

Influence of HEK293 metabolism on the production of viral vectors and vaccine

(2015) Emma Petiot et al.   VACCINE

Plant-derived H7 VLP vaccine elicits protective immune response against H7N9 influenza virus in mice and ferrets

(2015) S. Pillet et al.   VACCINE

Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9) virus infection in ferrets

(2015) Ye V. Liu et al.   VACCINE

H5N1 influenza virus-like particle vaccine protects mice from heterologous virus challenge better than whole inactivated virus

(2015) Zhiguang Ren et al.   VIRUS RESEARCH

Characterization of Humoral Responses Induced by an H7N9 Influenza Virus-Like Particle Vaccine in BALB/C Mice

(2015) Li Zhang et al.   Viruses-Basel

Modulating secretory pathway pH by proton channel co-expression can increase recombinant protein stability in plants

(2015) Philippe V. Jutras et al.   Biotechnology Journal

Next generation vaccines and vectors: Designing downstream processes for recombinant protein-based virus-like particles

(2015) Christopher Ladd Effio et al.   Biotechnology Journal

Effect of Osmotic Pressure on the Stability of Whole Inactivated Influenza Vaccine for Coating on Microneedles

(2015) Hyo-Jick Choi et al.   PLoS One

Vaccine instability in the cold chain: Mechanisms, analysis and formulation strategies

(2014) Ozan S. Kumru et al.   BIOLOGICALS

Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens

(2014) Nathalie Landry et al.   CLINICAL IMMUNOLOGY

Fully aseptic single-use cross flow filtration system for clarification and concentration of cytomegalovirus-like particles

(2014) Tiago Vicente et al.   ENGINEERING IN LIFE SCIENCES

Advances and challenges in the development and production of effective plant-based influenza vaccines

(2014) Vidadi Yusibov et al.   Expert Review of Vaccines

Update on baculovirus as an expression and/or delivery vehicle for vaccine antigens

(2014) Shih-Yeh Lin et al.   Expert Review of Vaccines

Biochemical composition of haemagglutinin-based influenza virus-like particle vaccine produced by transient expression in tobacco plants

(2014) François Le Mauff et al.   PLANT BIOTECHNOLOGY JOURNAL

Purification of Vero cell derived live replication deficient influenza A and B virus by ion exchange monolith chromatography

(2014) Marko Banjac et al.   VACCINE

Plant-based vaccines against viruses

(2014) Edward P Rybicki   Virology Journal

Conserved and host-specific features of influenza virion architecture

(2014) Edward C. Hutchinson et al.   Nature Communications

Recent advances in bioprocessing application of membrane chromatography

(2013) Valerie Orr et al.   BIOTECHNOLOGY ADVANCES

Bioengineering virus-like particles as vaccines

(2013) Linda H.L. Lua et al.   BIOTECHNOLOGY AND BIOENGINEERING

Tnao38, high five and Sf9—evaluation of host–virus interactions in three different insect cell lines: baculovirus production and recombinant protein expression

(2013) Monika Wilde et al.   BIOTECHNOLOGY LETTERS

Insect cells as a production platform of complex virus-like particles

(2013) Fabiana Fernandes et al.   Expert Review of Vaccines

Use of hollow fiber tangential flow filtration for the recovery and concentration of HIV virus-like particles produced in insect cells

(2013) Alejandro Negrete et al.   JOURNAL OF VIROLOGICAL METHODS

Virus-like particle-based human vaccines: quality assessment based on structural and functional properties

(2013) Qinjian Zhao et al.   TRENDS IN BIOTECHNOLOGY

Virus-like particle vaccine protects against H3N2 canine influenza virus in dog

(2013) Dong-Hun Lee et al.   VACCINE

Development of influenza H7N9 virus like particle (VLP) vaccine: Homologous A/Anhui/1/2013 (H7N9) protection and heterologous A/chicken/Jalisco/CPA1/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus

(2013) Gale E. Smith et al.   VACCINE

One-shot vaccination with an insect cell-derived low-dose influenza A H7 virus-like particle preparation protects mice against H7N9 challenge

(2013) Miriam Klausberger et al.   VACCINE

Mucosal Adjuvants for Influenza Virus-Like Particle Vaccine

(2013) Fu-Shi Quan et al.   VIRAL IMMUNOLOGY

Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses

(2013) Irina Tretyakova et al.   VIROLOGY

Co-expression vs. co-infection using baculovirus expression vectors in insect cell culture: Benefits and drawbacks

(2012) Stanislav Sokolenko et al.   BIOTECHNOLOGY ADVANCES

Protective efficacy of crude virus-like particle vaccine against HPAI H5N1 in chickens and its application on DIVA strategy

(2012) Jae-Keun Park et al.   Influenza and Other Respiratory Viruses

Transient Expression of Hemagglutinin Antigen from Low Pathogenic Avian Influenza A (H7N7) in Nicotiana benthamiana

(2012) Selvaraju Kanagarajan et al.   PLoS One

SweetBac: A New Approach for the Production of Mammalianised Glycoproteins in Insect Cells

(2012) Dieter Palmberger et al.   PLoS One

Residual Baculovirus in Insect Cell-Derived Influenza Virus-Like Particle Preparations Enhances Immunogenicity

(2012) Irina Margine et al.   PLoS One

Production and characterization of mammalian virus-like particles from modified vaccinia virus Ankara vectors expressing influenza H5N1 hemagglutinin and neuraminidase

(2012) Falko Schmeisser et al.   VACCINE

Global production capacity of seasonal influenza vaccine in 2011

(2012) Jeffrey Partridge et al.   VACCINE

Protective efficacy of baculovirus-derived influenza virus-like particles bearing H5 HA alone or in combination with M1 in chickens

(2012) Jun-Gu Choi et al.   VETERINARY MICROBIOLOGY

Influenza M1 VLPs containing neuraminidase induce heterosubtypic cross-protection

(2012) Fu-Shi Quan et al.   VIROLOGY

Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice

(2012) Judith D. Easterbrook et al.   VIROLOGY

Plant-derived virus-like particles as vaccines

(2012) Qiang Chen et al.   Human Vaccines & Immunotherapeutics

MultiBac turns sweet

(2012) Dieter Palmberger et al.   Bioengineered

Rational design and optimization of downstream processes of virus particles for biopharmaceutical applications: Current advances

(2011) Tiago Vicente et al.   BIOTECHNOLOGY ADVANCES

Baculovirus as a gene delivery vector: Recent understandings of molecular alterations in transduced cells and latest applications

(2011) Chi-Yuan Chen et al.   BIOTECHNOLOGY ADVANCES

Virus-Like Particle Vaccine Containing Hemagglutinin Confers Protection against 2009 H1N1 Pandemic Influenza

(2011) M. Jaber Hossain et al.   Clinical and Vaccine Immunology

Downstream processing of cell culture-derived virus particles

(2011) Michael W Wolf et al.   Expert Review of Vaccines

Ultracentrifugation deforms unfixed influenza A virions

(2011) Y. Sugita et al.   JOURNAL OF GENERAL VIROLOGY

Large-scale production and purification of VLP-based vaccines

(2011) Tiago Vicente et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

Proteomic Characterization of Influenza H5N1 Virus-like Particles and Their Protective Immunogenicity

(2011) Jae-Min Song et al.   JOURNAL OF PROTEOME RESEARCH

Production of immunogenic one-component avian H7-subtype influenza virus-like particles

(2011) Gary Ro-Lin Chang et al.   PROCESS BIOCHEMISTRY

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico

(2011) Constantino López-Macías et al.   VACCINE

Fabrication of influenza virus-like particles using M2 fusion proteins for imaging single viruses and designing vaccines

(2011) Hung-Ju Wei et al.   VACCINE

H9N2 avian influenza virus-like particle vaccine provides protective immunity and a strategy for the differentiation of infected from vaccinated animals

(2011) Dong-Hun Lee et al.   VACCINE

Influenza virus-like particle can accommodate multiple subtypes of hemagglutinin and protect from multiple influenza types and subtypes

(2011) Peter Pushko et al.   VACCINE

Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs

(2011) Hyun-Mi Pyo et al.   VACCINE

Baculovirus-Produced Influenza Virus-like Particles in Mammalian Cells Protect Mice from Lethal Influenza Challenge

(2011) Xian-Chun Tang et al.   VIRAL IMMUNOLOGY

Influenza virus assembly and budding

(2011) Jeremy S. Rossman et al.   VIROLOGY

Bioprocessing of Baculovirus Vectors: A Review

(2010) Marc G. Aucoin et al.   CURRENT GENE THERAPY

Virus-like particles in vaccine development

(2010) António Roldão et al.   Expert Review of Vaccines

The Lack of an Inherent Membrane Targeting Signal Is Responsible for the Failure of the Matrix (M1) Protein of Influenza A Virus To Bud into Virus-Like Particles

(2010) D. Wang et al.   JOURNAL OF VIROLOGY

Trichoplusia ni cells (High FiveTM) are highly efficient for the production of influenza A virus-like particles: a comparison of two insect cell lines as production platforms for influenza vaccines

(2010) Florian Krammer et al.   MOLECULAR BIOTECHNOLOGY

The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza

(2010) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Mammalian Expression of Virus-Like Particles for Advanced Mimicry of Authentic Influenza Virus

(2010) Chia-Ying Wu et al.   PLoS One

Virus-Like Particle Vaccine Protects against 2009 H1N1 Pandemic Influenza Virus in Mice

(2010) Fu-Shi Quan et al.   PLoS One

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Alternative influenza vaccines made by insect cells

(2010) Florian Krammer et al.   TRENDS IN MOLECULAR MEDICINE

Scalable production of influenza virus in HEK-293 cells for efficient vaccine manufacturing

(2010) Audrey Le Ru et al.   VACCINE

Recombinant H1N1 virus-like particle vaccine elicits protective immunity in ferrets against the 2009 pandemic H1N1 influenza virus

(2010) Peter Pushko et al.   VACCINE

Protective immunity against H5N1 influenza virus by a single dose vaccination with virus-like particles

(2010) Jae-Min Song et al.   VIROLOGY

Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge

(2009) Zhiyuan Wen et al.   ANTIVIRAL RESEARCH

Influenza virus-like particle vaccines

(2009) Joel R Haynes   Expert Review of Vaccines

Continuous cell lines as a production system for influenza vaccines

(2009) Yvonne Genzel et al.   Expert Review of Vaccines

Development of a scalable process for high-yield lentiviral vector production by transient transfection of HEK293 suspension cultures

(2009) Sven Ansorge et al.   JOURNAL OF GENE MEDICINE

DNA Vaccination with a Single‐Plasmid Construct Coding for Viruslike Particles Protects Mice against Infection with a Highly Pathogenic Avian Influenza A Virus

(2009) Judit Szécsi et al.   JOURNAL OF INFECTIOUS DISEASES

Induction of Long-Term Protective Immune Responses by Influenza H5N1 Virus-Like Particles

(2009) Sang-Moo Kang et al.   PLoS One

Virus-Like Particle Vaccine Comprised of the HA, NA, and M1 Proteins of an Avian Isolated H5N1 Influenza Virus Induces Protective Immunity Against Homologous and Heterologous Strains in Mice

(2009) Pan Tao et al.   VIRAL IMMUNOLOGY

Influenza vaccines based on virus-like particles

(2009) Sang-Moo Kang et al.   VIRUS RESEARCH

Influenza virus morphogenesis and budding

(2009) Debi P. Nayak et al.   VIRUS RESEARCH

Baculovirus production for gene therapy: the role of cell density, multiplicity of infection and medium exchange

(2008) Nuno Carinhas et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Baculovirus as an expression and/or delivery vehicle for vaccine antigens

(2008) Yu-Chen Hu et al.   Expert Review of Vaccines

Size-exclusion chromatography as a linear transfer system: Purification of human influenza virus as an example

(2008) Bernd Kalbfuss et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Discrimination between exosomes and HIV-1: Purification of both vesicles from cell-free supernatants

(2008) Réjean Cantin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Influenza virus-like particles produced by transient expression inNicotiana benthamianainduce a protective immune response against a lethal viral challenge in mice

(2008) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Cross-Clade Protective Immune Responses to Influenza Viruses with H5N1 HA and NA Elicited by an Influenza Virus-Like Particle

(2008) Rick A. Bright et al.   PLoS One

A bivalent influenza VLP vaccine confers complete inhibition of virus replication in lungs

(2008) Fu Shi Quan et al.   VACCINE

Influenza-pseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge

(2008) Joel R. Haynes et al.   VACCINE