Next generation vaccines and vectors: Designing downstream processes for recombinant protein-based virus-like particles

Capture and intermediate purification of recombinant antibodies with combined precipitation methods

(2015) Ralf Sommer et al.   BIOCHEMICAL ENGINEERING JOURNAL

Single stage aqueous two-phase extraction for monoclonal antibody purification from cell supernatant

(2015) Jan Muendges et al.   FLUID PHASE EQUILIBRIA

Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma

(2015) Monika Zochowska et al.   Nanomedicine-Nanotechnology Biology and Medicine

Robust mucosal-homing antibody-secreting B cell responses induced by intramuscular administration of adjuvanted bivalent human norovirus-like particle vaccine

(2015) Aarthi Sundararajan et al.   VACCINE

ACTIVE AB IMMUNOTHERAPY CAD106 PHASE II DOSE-ADJUVANT FINDING STUDY: IMMUNE RESPONSE

(2014) Marie-Emmanuelle Riviere et al.   Alzheimers & Dementia

ACTIVE AB IMMUNOTHERAPY CAD106 PHASE II DOSE-ADJUVANT FINDING STUDY: AMYLOID PET

(2014) Angelika Caputo et al.   Alzheimers & Dementia

Coxsackievirus B3 VLPs purified by ion exchange chromatography elicit strong immune responses in mice

(2014) Tiia Koho et al.   ANTIVIRAL RESEARCH

A tool for selective inline quantification of co-eluting proteins in chromatography using spectral analysis and partial least squares regression

(2014) Nina Brestrich et al.   BIOTECHNOLOGY AND BIOENGINEERING

Multi-Stage Aqueous Two-Phase Extraction for the Purification of Monoclonal Antibodies

(2014) Jan K. Eggersgluess et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Update on Vaccination Clinical Trials for HPV-Related Disease

(2014) Britt K. Erickson et al.   CLINICAL THERAPEUTICS

Adjoint-based estimation and optimization for column liquid chromatography models

(2014) Tobias Hahn et al.   COMPUTERS & CHEMICAL ENGINEERING

Fully aseptic single-use cross flow filtration system for clarification and concentration of cytomegalovirus-like particles

(2014) Tiago Vicente et al.   ENGINEERING IN LIFE SCIENCES

Adenovirus purification by two-column, size-exclusion, simulated countercurrent chromatography

(2014) Piergiuseppe Nestola et al.   JOURNAL OF CHROMATOGRAPHY A

International community ramps up Ebola vaccine effort

(2014) Dara Mohammadi   LANCET

Secreted production of assembled Norovirus virus-like particles from Pichia pastoris

(2014) Jaime Tomé-Amat et al.   Microbial Cell Factories

Enhanced Production of Chikungunya Virus-Like Particles Using a High-pH Adapted Spodoptera frugiperda Insect Cell Line

(2014) James M. Wagner et al.   PLoS One

Decreased Management of Genital Warts in Young Women in Australian General Practice Post Introduction of National HPV Vaccination Program: Results from a Nationally Representative Cross-Sectional General Practice Study

(2014) Christopher Harrison et al.   PLoS One

Model-based integrated optimization and evaluation of a multi-step ion exchange chromatography

(2014) Thiemo C. Huuk et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Efficacy of the HPV-16/18 vaccine: Final according to protocol results from the blinded phase of the randomized Costa Rica HPV-16/18 vaccine trial

(2014) Allan Hildesheim et al.   VACCINE

Immunogenicity and safety of the candidate RTS,S/AS01 vaccine in young Nigerian children: A randomized, double-blind, lot-to-lot consistency trial

(2014) Rich Umeh et al.   VACCINE

Robust manufacturing and comprehensive characterization of recombinant hepatitis E virus-like particles in Hecolin®

(2014) Xiao Zhang et al.   VACCINE

A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice

(2014) Zhiqiang Ku et al.   VACCINE

Aβ-HBc virus-like particles immunization without additional adjuvant ameliorates the learning and memory and reduces Aβ deposit in PDAPP mice

(2014) Hui Jin et al.   VACCINE

Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines

(2014) Brian J. Ward et al.   VACCINE

Improved characteristics and protective efficacy in an animal model of E. coli-derived recombinant double-layered rotavirus virus-like particles

(2014) Tingdong Li et al.   VACCINE

HPV vaccines to prevent cervical cancer and genital warts: an update

(2014) Carine Dochez et al.   VACCINE

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: Results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers

(2014) Jenny G.H. Low et al.   VACCINE

Quantitative real-time single particle analysis of virions

(2014) Susanne Heider et al.   VIROLOGY

Concentration and purification of enterovirus 71 using a weak anion-exchange monolithic column

(2014) Ashok Kattur Venkatachalam et al.   Virology Journal

Stimulating antitumor immunity with nanoparticles

(2014) Mee Rie Sheen et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Preclinical efficacy and safety of an anti-IL-1β vaccine for the treatment of type 2 diabetes

(2014) Gunther Spohn et al.   Molecular Therapy-Methods & Clinical Development

Recent advances in bioprocessing application of membrane chromatography

(2013) Valerie Orr et al.   BIOTECHNOLOGY ADVANCES

Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants

(2013) Yap P. Chuan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bioengineering virus-like particles as vaccines

(2013) Linda H.L. Lua et al.   BIOTECHNOLOGY AND BIOENGINEERING

Evaluation of PEG/phosphate aqueous two-phase systems for the purification of the chicken egg white protein avidin by using high-throughput techniques

(2013) Patrick Diederich et al.   CHEMICAL ENGINEERING SCIENCE

Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures

(2013) Peter Pushko et al.   INTERVIROLOGY

Alternative separation steps for monoclonal antibody purification: Combination of centrifugal partitioning chromatography and precipitation

(2013) Stefan A. Oelmeier et al.   JOURNAL OF CHROMATOGRAPHY A

Continuous purification of influenza virus using simulated moving bed chromatography

(2013) T. Kröber et al.   JOURNAL OF CHROMATOGRAPHY A

High productivity purification of immunoglobulin G monoclonal antibodies on starch-coated magnetic nanoparticles by steric exclusion of polyethylene glycol

(2013) Pete Gagnon et al.   JOURNAL OF CHROMATOGRAPHY A

Utilizing Dynamic Light Scattering as a Process Analytical Technology for Protein Folding and Aggregation Monitoring in Vaccine Manufacturing

(2013) Zhou Yu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations

(2013) Lin Zhang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Inequalities in Human Papillomavirus (HPV)–Associated Cancers: Implications for the Success of HPV Vaccination

(2013) Marc Brisson et al.   JNCI-Journal of the National Cancer Institute

An affinity chromatography method used to purify His-tag-displaying bio-nanocapsules

(2013) Yuya Nishimura et al.   JOURNAL OF VIROLOGICAL METHODS

Use of hollow fiber tangential flow filtration for the recovery and concentration of HIV virus-like particles produced in insect cells

(2013) Alejandro Negrete et al.   JOURNAL OF VIROLOGICAL METHODS

Virus-like particle formulation optimization by miniaturized high-throughput screening

(2013) Johannes Mohr et al.   METHODS

A Recombinant Viruslike Particle Influenza A (H7N9) Vaccine

(2013) Louis F. Fries et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chromatographically-purified capsid proteins of red-spotted grouper nervous necrosis virus expressed in Saccharomyces cerevisiae form virus-like particles

(2013) Yoo Ri Choi et al.   PROTEIN EXPRESSION AND PURIFICATION

Active immunotherapy for chronic diseases

(2013) Martin F. Bachmann et al.   VACCINE

Generation of a parvovirus B19 vaccine candidate

(2013) Sumana Chandramouli et al.   VACCINE

Chikungunya virus-like particles are more immunogenic in a lethal AG129 mouse model compared to glycoprotein E1 or E2 subunits

(2013) Stefan W. Metz et al.   VACCINE

Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells

(2013) Stefan W. Metz et al.   PLoS Neglected Tropical Diseases

Reactive diafiltration for assembly and formulation of virus-like particles

(2012) Mervyn W.O. Liew et al.   BIOCHEMICAL ENGINEERING JOURNAL

Immunogenicity of HIV Virus-Like Particles in Rhesus Macaques by Intranasal Administration

(2012) Luigi Buonaguro et al.   Clinical and Vaccine Immunology

High throughput screening based selection of phases for aqueous two-phase system-centrifugal partitioning chromatography of monoclonal antibodies

(2012) Stefan A. Oelmeier et al.   JOURNAL OF CHROMATOGRAPHY A

Principles and applications of steric exclusion chromatography

(2012) Jeremy Lee et al.   JOURNAL OF CHROMATOGRAPHY A

Design of a microfluidic platform for monoclonal antibody extraction using an aqueous two-phase system

(2012) D.F.C. Silva et al.   JOURNAL OF CHROMATOGRAPHY A

Innate Immunity Mediates Follicular Transport of Particulate but Not Soluble Protein Antigen

(2012) A. Link et al.   JOURNAL OF IMMUNOLOGY

High-throughput screening-based selection and scale-up of aqueous two-phase systems for pDNA purification

(2012) Matthias Wiendahl et al.   JOURNAL OF SEPARATION SCIENCE

Purification of norovirus-like particles (VLPs) by ion exchange chromatography

(2012) Tiia Koho et al.   JOURNAL OF VIROLOGICAL METHODS

Evaluation of four virus recovery methods for detecting noroviruses on fresh lettuce, sliced ham, and frozen raspberries

(2012) Maija Summa et al.   JOURNAL OF VIROLOGICAL METHODS

Rapid and simplified purification of recombinant adeno-associated virus

(2012) Ping Guo et al.   JOURNAL OF VIROLOGICAL METHODS

Construction and Characterization of Virus-Like Particles: A Review

(2012) Andris Zeltins   MOLECULAR BIOTECHNOLOGY

Disassembly and reassembly improves morphology and thermal stability of human papillomavirus type 16 virus-like particles

(2012) Qinjian Zhao et al.   Nanomedicine-Nanotechnology Biology and Medicine

Vaccine Efficacy against Malaria by the Combination of Porcine Parvovirus-Like Particles and Vaccinia Virus Vectors Expressing CS of Plasmodium

(2012) Dolores Rodríguez et al.   PLoS One

Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development

(2012) Natasha Kushnir et al.   VACCINE

Safety and immunogenicity of a Sf9 insect cell-derived respiratory syncytial virus fusion protein nanoparticle vaccine

(2012) Gregory M. Glenn et al.   VACCINE

Influenza M1 VLPs containing neuraminidase induce heterosubtypic cross-protection

(2012) Fu-Shi Quan et al.   VIROLOGY

Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like antibody reactivity

(2012) Qinjian Zhao et al.   Virology Journal

On the Effect of Thermodynamic Equilibrium on the Assembly Efficiency of Complex Multi-Layered Virus-Like Particles (VLP): the Case of Rotavirus VLP

(2012) António Roldão et al.   PLoS Computational Biology

Dynamic filtration with rotating disks, and rotating and vibrating membranes: an update

(2012) Michel Y Jaffrin   Current Opinion in Chemical Engineering

Human parvovirus B19 virus-like particles: In vitro assembly and stability

(2011) Sandra P. Sánchez-Rodríguez et al.   BIOCHIMIE

Highly Specific Auto-Antibodies against Claudin-18 Isoform 2 Induced by a Chimeric HBcAg Virus-Like Particle Vaccine Kill Tumor Cells and Inhibit the Growth of Lung Metastases

(2011) Thorsten Klamp et al.   CANCER RESEARCH

Recovery of B19 virus-like particles by aqueous two-phase systems

(2011) Frank Luechau et al.   FOOD AND BIOPRODUCTS PROCESSING

Efficient disulfide bond formation in virus-like particles

(2011) Bradley C. Bundy et al.   JOURNAL OF BIOTECHNOLOGY

Protein precipitation by polyethylene glycol: A generalized model based on hydrodynamic radius

(2011) Siow-Leng Sim et al.   JOURNAL OF BIOTECHNOLOGY

Reduced surface area chromatography for flow-through purification of viruses and virus like particles

(2011) Ganesh Iyer et al.   JOURNAL OF CHROMATOGRAPHY A

Purification of recombinant adenovirus type 3 dodecahedric virus-like particles for biomedical applications using short monolithic columns

(2011) Lidija Urbas et al.   JOURNAL OF CHROMATOGRAPHY A

Scale-up of protein purifications using aqueous two-phase systems: Comparing multilayer toroidal coil chromatography with centrifugal partition chromatography

(2011) Ian Sutherland et al.   JOURNAL OF CHROMATOGRAPHY A

Continuous aqueous two-phase extraction of human antibodies using a packed column

(2011) P.A.J. Rosa et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A monolith purification process for virus-like particles from yeast homogenate

(2011) Claire S. Burden et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Large-scale production and purification of VLP-based vaccines

(2011) Tiago Vicente et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

Purification and concentration of non-infectious West Nile virus-like particles and infectious virions using a pseudo-affinity Cellufine Sulfate column

(2011) Naohiro Ohtaki et al.   JOURNAL OF VIROLOGICAL METHODS

Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the Hepatitis B surface antigen

(2011) Heinrich Lünsdorf et al.   Microbial Cell Factories

Purification and immunogenicity study of human papillomavirus 58 virus-like particles expressed in Pichia pastoris

(2011) Zijun Jiang et al.   PROTEIN EXPRESSION AND PURIFICATION

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico

(2011) Constantino López-Macías et al.   VACCINE

Safety and immunogenicity of a candidate parvovirus B19 vaccine

(2011) David I. Bernstein et al.   VACCINE

Next generation dengue vaccines: A review of candidates in preclinical development

(2011) Julia Schmitz et al.   VACCINE

Modeling the competition between aggregation and self-assembly during virus-like particle processing

(2010) Yong Ding et al.   BIOTECHNOLOGY AND BIOENGINEERING

A single-use purification process for the production of a monoclonal antibody produced in a PER.C6 human cell line

(2010) Michael Kuczewski et al.   Biotechnology Journal

Structure of Hepatitis E Virion-sized Particle Reveals an RNA-dependent Viral Assembly Pathway

(2010) Li Xing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purification of His-tagged hepatitis B core antigen from unclarified bacterial homogenate using immobilized metal affinity-expanded bed adsorption chromatography

(2010) Wei Boon Yap et al.   JOURNAL OF CHROMATOGRAPHY A

COMMENTARY: Acceptable Levels of Endotoxin in Vaccine Formulations During Preclinical Research

(2010) Luis A. Brito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Adsorption of plasmid DNA on ceramic hydroxyapatite chromatographic materials

(2010) Elisabeth Schmoeger et al.   JOURNAL OF SEPARATION SCIENCE

Norwalk Virus Assembly and Stability Monitored by Mass Spectrometry

(2010) Glen K. Shoemaker et al.   MOLECULAR & CELLULAR PROTEOMICS

Interrogating viral capsid assembly with ion mobility–mass spectrometry

(2010) Charlotte Uetrecht et al.   Nature Chemistry

Enterovirus 71 virus-like particle vaccine: Improved production conditions for enhanced yield

(2010) Cheng-Yu Chung et al.   VACCINE

HPV Vaccines: Preclinical Development

(2009) Lutz Gissmann   ARCHIVES OF MEDICAL RESEARCH

High-throughput screening techniques for rapid PEG-based precipitation of IgG4 mAb from clarified cell culture supernatant

(2009) Carol Knevelman et al.   BIOTECHNOLOGY PROGRESS

A novel stationary phase derivatized from hydrophilic gigaporous polystyrene-based microspheres for high-speed protein chromatography

(2009) Jian-Bo Qu et al.   JOURNAL OF CHROMATOGRAPHY A

Affinity purification of viral protein having heterogeneous quaternary structure: Modeling the impact of soluble aggregates on chromatographic performance

(2009) Daniel I. Lipin et al.   JOURNAL OF CHROMATOGRAPHY A

Aqueous two-phase systems: A viable platform in the manufacturing of biopharmaceuticals

(2009) P.A.J. Rosa et al.   JOURNAL OF CHROMATOGRAPHY A

Depletion Theory and the Precipitation of Protein by Polymer†

(2009) Theo Odijk   JOURNAL OF PHYSICAL CHEMISTRY B

PEG enhances viral clearance on ceramic hydroxyapatite

(2009) Mark A. Snyder et al.   JOURNAL OF SEPARATION SCIENCE

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY

One-step chromatographic purification of human papillomavirus type 16 L1 protein from Saccharomyces cerevisiae

(2009) Hyoung Jin Kim et al.   PROTEIN EXPRESSION AND PURIFICATION

Development of the RTS,S/AS malaria candidate vaccine

(2009) Johan Vekemans et al.   VACCINE

Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy

(2008) Leonard F. Pease et al.   BIOTECHNOLOGY AND BIOENGINEERING

High Throughput Screening for the Design and Optimization of Chromatographic Processes – Miniaturization, Automation and Parallelization of Breakthrough and Elution Studies

(2008) M. Wiendahl et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Effect of different operating modes and biomass concentrations on the recovery of recombinant hepatitis B core antigen from thermal-treated unclarified Escherichia coli feedstock

(2008) Michelle Y.T. Ng et al.   JOURNAL OF BIOTECHNOLOGY

Critical evaluation and comparison of fluid distribution systems for industrial scale expanded bed adsorption chromatography columns

(2008) A. Arpanaei et al.   JOURNAL OF CHROMATOGRAPHY A

Polymethacrylate monoliths for preparative and industrial separation of biomolecular assemblies

(2008) Alois Jungbauer et al.   JOURNAL OF CHROMATOGRAPHY A

A Quantitative Description of In Vitro Assembly of Human Papillomavirus 16 Virus-Like Particles

(2008) Santanu Mukherjee et al.   JOURNAL OF MOLECULAR BIOLOGY

Liquid high concentration IgG1 antibody formulations by precipitation

(2008) Susanne Matheus et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Purification and analysis of polyhistidine-tagged human parvovirus B19 VP1 and VP2 expressed in insect cells

(2008) Patrik O. Michel et al.   JOURNAL OF VIROLOGICAL METHODS

Anion-exchange membrane chromatography for purification of rotavirus-like particles

(2007) Tiago Vicente et al.   JOURNAL OF MEMBRANE SCIENCE