Universal influenza vaccines: from viruses to nanoparticles

Preparation and immunological evaluation of inactivated avian influenza virus vaccine encapsulated in chitosan nanoparticles

(2018) Samah H. Mohamed et al.   BIOLOGICALS

Intranasal Nanovaccine Confers Homo- and Hetero-Subtypic Influenza Protection

(2018) Mi Qi et al.   Small

Towards a universal influenza vaccine: different approaches for one goal

(2018) Giuseppe A. Sautto et al.   Virology Journal

Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses

(2018) Lei Deng et al.   Nature Communications

Mucosal Immunity and Protective Efficacy of Intranasal Inactivated Influenza Vaccine Is Improved by Chitosan Nanoparticle Delivery in Pigs

(2018) Santosh Dhakal et al.   Frontiers in Immunology

Update: Influenza Activity — United States, October 1, 2017–February 3, 2018

(2018) Alicia P. Budd et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice

(2018) Lei Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus

(2017) Nicholas C. Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection

(2017) D G Eliasson et al.   Mucosal Immunology

Vaccination with self-adjuvanted protein nanoparticles provides protection against lethal influenza challenge

(2017) Christopher P. Karch et al.   Nanomedicine-Nanotechnology Biology and Medicine

Coated protein nanoclusters from influenza H7N9 HA are highly immunogenic and induce robust protective immunity

(2017) Li Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Broadened immunity and protective responses with emulsion-adjuvanted H5 COBRA-VLP vaccines

(2017) James D. Allen et al.   VACCINE

A single dose and long lasting vaccine against pandemic influenza through the controlled release of a heterospecies tandem M2 sequence embedded within detoxified bacterial outer membrane vesicles

(2017) Hannah C. Watkins et al.   VACCINE

Mucosal vaccination of conserved sM2, HA2 and cholera toxin subunit A1 (CTA1) fusion protein with poly gamma-glutamate/chitosan nanoparticles (PC NPs) induces protection against divergent influenza subtypes

(2017) Mohammed Y.E. Chowdhury et al.   VETERINARY MICROBIOLOGY

Protein nanoparticle vaccine based on flagellin carrier fused to influenza conserved epitopes confers full protection against influenza A virus challenge

(2017) Lei Deng et al.   VIROLOGY

Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing

(2017) Timothy Z. Chang et al.   Biomaterials Science

Comparison of the Protective Efficacy of Neutralizing Epitopes of 2009 Pandemic H1N1 Influenza Hemagglutinin

(2017) Bo Peng et al.   Frontiers in Immunology

Cross-Protective Efficacy of Influenza Virus M2e Containing Virus-Like Particles Is Superior to Hemagglutinin Vaccines and Variable Depending on the Genetic Backgrounds of Mice

(2017) Yu-Jin Kim et al.   Frontiers in Immunology

Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection

(2017) Kristien Van Reeth et al.   npj Vaccines

Chimeric virus-like particles containing influenza HA antigen and GPI-CCL28 induce long-lasting mucosal immunity against H3N2 viruses

(2017) Teena Mohan et al.   Scientific Reports

Multi-subtype influenza virus-like particles incorporated with flagellin and granulocyte-macrophage colony-stimulating factor for vaccine design

(2016) Wen-Chun Liu et al.   ANTIVIRAL RESEARCH

Natural supramolecular protein assemblies

(2016) Bas J. G. E. Pieters et al.   CHEMICAL SOCIETY REVIEWS

Optimisation of one-step desolvation and scale-up of gelatine nanoparticle production

(2016) Katharina J. Geh et al.   JOURNAL OF MICROENCAPSULATION

Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza Viruses

(2016) Donald M. Carter et al.   JOURNAL OF VIROLOGY

Effects of modification of the HIV-1 Env cytoplasmic tail on immunogenicity of VLP vaccines

(2016) Andrei N. Vzorov et al.   VIROLOGY

Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model

(2016) Matthew J. Memoli et al.   mBio

Self-assembling protein nanoparticles in the design of vaccines

(2016) Jacinto López-Sagaseta et al.   Computational and Structural Biotechnology Journal

Entrapment of H1N1 Influenza Virus Derived Conserved Peptides in PLGA Nanoparticles Enhances T Cell Response and Vaccine Efficacy in Pigs

(2016) Jagadish Hiremath et al.   PLoS One

Microneedle patch delivery to the skin of virus-like particles containing heterologous M2e extracellular domains of influenza virus induces broad heterosubtypic cross-protection

(2015) Min-Chul Kim et al.   JOURNAL OF CONTROLLED RELEASE

Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease

(2015) Valerie L. Herrmann et al.   JOURNAL OF CONTROLLED RELEASE

Dissolving Microneedle Delivery of Nanoparticle-Encapsulated Antigen Elicits Efficient Cross-Priming and Th1 Immune Responses by Murine Langerhans Cells

(2015) Marija Zaric et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

Virus-specific T cells as correlate of (cross-)protective immunity against influenza

(2015) Arwen F. Altenburg et al.   VACCINE

Peptide/protein vaccine delivery system based on PLGA particles

(2015) Mojgan Allahyari et al.   Human Vaccines & Immunotherapeutics

Cocktail of H5N1 COBRA HA vaccines elicit protective antibodies against H5N1 viruses from multiple clades

(2015) Corey J Crevar et al.   Human Vaccines & Immunotherapeutics

Safety and Biocompatibility of Carbohydrate-Functionalized Polyanhydride Nanoparticles

(2014) Julia E. Vela-Ramirez et al.   AAPS Journal

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

(2014) Fatemeh Sadat Tabatabaei Mirakabad et al.   Asian Pacific Journal of Cancer Prevention

Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection

(2014) V. V. A. Mallajosyula et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza M2 virus-like particles confer a broader range of cross protection to the strain-specific pre-existing immunity

(2014) Min-Chul Kim et al.   VACCINE

Universal Influenza Vaccines, a Dream to Be Realized Soon

(2014) Han Zhang et al.   Viruses-Basel

Multiple heterologous M2 extracellular domains presented on virus-like particles confer broader and stronger M2 immunity than live influenza A virus infection

(2013) Min-Chul Kim et al.   ANTIVIRAL RESEARCH

Universal anti-neuraminidase antibody inhibiting all influenza A subtypes

(2013) Tracey M. Doyle et al.   ANTIVIRAL RESEARCH

Long-Term Protective Immunity from an Influenza Virus-Like Particle Vaccine Administered with a Microneedle Patch

(2013) Fu-Shi Quan et al.   Clinical and Vaccine Immunology

Microarrays and microneedle arrays for delivery of peptides, proteins, vaccines and other applications

(2013) Saradha Chandrasekhar et al.   Expert Opinion on Drug Delivery

Virus-like particles produced in plants as potential vaccines

(2013) Nunzia Scotti et al.   Expert Review of Vaccines

Insect cells as a production platform of complex virus-like particles

(2013) Fabiana Fernandes et al.   Expert Review of Vaccines

Development of universal influenza vaccines based on influenza virus M and NP genes

(2013) M. Zheng et al.   INFECTION

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Coadministration of Seasonal Influenza Vaccine and MVA-NP+M1 Simultaneously Achieves Potent Humoral and Cell-Mediated Responses

(2013) Richard D Antrobus et al.   MOLECULAR THERAPY

Nanoclusters self-assembled from conformation-stabilized influenza M2e as broadly cross-protective influenza vaccines

(2013) Li Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

(2013) Masaru Kanekiyo et al.   NATURE

The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells

(2013) William R Heath et al.   NATURE IMMUNOLOGY

Cellular immune correlates of protection against symptomatic pandemic influenza

(2013) Saranya Sridhar et al.   NATURE MEDICINE

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Self-Assembling Cages from Coiled-Coil Peptide Modules

(2013) J. M. Fletcher et al.   SCIENCE

Enhanced Influenza Virus-Like Particle Vaccines Containing the Extracellular Domain of Matrix Protein 2 and a Toll-Like Receptor Ligand

(2012) Bao-Zhong Wang et al.   Clinical and Vaccine Immunology

Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans

(2012) Patrick J. Lillie et al.   CLINICAL INFECTIOUS DISEASES

Virus-like particles as universal influenza vaccines

(2012) Sang-Moo Kang et al.   Expert Review of Vaccines

Virus-like Particles Containing Multiple M2 Extracellular Domains Confer Improved Cross-protection Against Various Subtypes of Influenza Virus

(2012) Min-Chul Kim et al.   MOLECULAR THERAPY

Development of a nanoparticle-based influenza vaccine using the PRINT® technology

(2012) Ashley L. Galloway et al.   Nanomedicine-Nanotechnology Biology and Medicine

A T Cell-Inducing Influenza Vaccine for the Elderly: Safety and Immunogenicity of MVA-NP+M1 in Adults Aged over 50 Years

(2012) Richard D. Antrobus et al.   PLoS One

Eccrine angiomatous hamartoma causing walking difficulties

(2011) Shuang Chen et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

Safety and immunogenicity of a recombinant M2e–flagellin influenza vaccine (STF2.4xM2e) in healthy adults

(2011) Christine B. Turley et al.   VACCINE

Antibodies against conserved antigens provide opportunities for reform in influenza vaccine design

(2011) Denise A. Kaminski   Frontiers in Immunology

A simple method for the preparation of monodisperse protein-loaded microspheres with high encapsulation efficiencies

(2010) Xinjian Cheng et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Egg-independent vaccine strategies for highly pathogenic H5N1 influenza viruses

(2010) Aseem Pandey et al.   Human vaccines & immunotherapeutics

Intradermal Vaccination with Influenza Virus-Like Particles by Using Microneedles Induces Protection Superior to That with Intramuscular Immunization

(2010) F.-S. Quan et al.   JOURNAL OF VIROLOGY

Microneedles in Clinical Practice–An Exploratory Study Into the Opinions of Healthcare Professionals and the Public

(2010) James C. Birchall et al.   PHARMACEUTICAL RESEARCH

Single-Dose Mucosal Immunization with a Candidate Universal Influenza Vaccine Provides Rapid Protection from Virulent H5N1, H3N2 and H1N1 Viruses

(2010) Graeme E. Price et al.   PLoS One

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Correlation of Cellular Immune Responses with Protection against Culture-Confirmed Influenza Virus in Young Children

(2008) B. D. Forrest et al.   Clinical and Vaccine Immunology

Effect of Microneedle Design on Pain in Human Volunteers

(2008) Harvinder S. Gill et al.   CLINICAL JOURNAL OF PAIN

Preparing polymer-based sustained-release systems without exposing proteins to water–oil or water–air interfaces and cross-linking reagents

(2008) Tuo Jin et al.   JOURNAL OF CONTROLLED RELEASE

Incorporation of Membrane-Anchored Flagellin into Influenza Virus-Like Particles Enhances the Breadth of Immune Responses

(2008) B.-Z. Wang et al.   JOURNAL OF VIROLOGY

Vaccination and antigenic drift in influenza

(2008) Maciej F. Boni   VACCINE