Potential Role of Antioxidant and Anti-Inflammatory Therapies to Prevent Severe SARS-Cov-2 Complications

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

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Emerging coronaviruses: Genome structure, replication, and pathogenesis

(2020) Yu Chen et al.   JOURNAL OF MEDICAL VIROLOGY

Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer

(2020) Sufang Tian et al.   Journal of Thoracic Oncology

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus

(2020) Mark F. McCarty et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

COVID-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome

(2020) Luciano Gattinoni et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection

(2020) Livan Delgado-Roche et al.   ARCHIVES OF MEDICAL RESEARCH

Nervous system involvement after infection with COVID-19 and other coronaviruses

(2020) Yeshun Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province

(2020) Kui Liu et al.   CHINESE MEDICAL JOURNAL

Angiotensin Converting Enzyme 2: A Double-Edged Sword

(2020) Kaiming Wang et al.   CIRCULATION

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Prominent changes in blood coagulation of patients with SARS-CoV-2 infection

(2020) Huan Han et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

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Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy

(2020) Graziano Onder et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China

(2020) Huan Han et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine “storm” and risk factor for damage of hematopoietic stem cells

(2020) Mariusz Z. Ratajczak et al.   LEUKEMIA

Liver impairment in COVID‐19 patients: A retrospective analysis of 115 cases from a single centre in Wuhan city, China

(2020) Yafei Zhang et al.   LIVER INTERNATIONAL

Clinical characteristics of non‐ICU hospitalized patients with coronavirus disease 2019 and liver injury: A retrospective study

(2020) Hansheng Xie et al.   LIVER INTERNATIONAL

N-Acetylcysteine: a potential therapeutic agent for SARS-CoV-2

(2020) Francis L. Poe et al.   MEDICAL HYPOTHESES

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses

(2020) Shibo Jiang et al.   TRENDS IN IMMUNOLOGY

Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

(2020) Changhai Lei et al.   Nature Communications

Covid-19: ibuprofen should not be used for managing symptoms, say doctors and scientists

(2020) Michael Day   BMJ-British Medical Journal

Non-steroidal anti-inflammatory drugs and covid-19

(2020) Paul Little   BMJ-British Medical Journal

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

(2020) Sharon E Fox et al.   Lancet Respiratory Medicine

Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19

(2020) Adnan Shah   Frontiers in Immunology

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants

(2020) Muhammad Tahir ul Qamar et al.   Journal of Pharmaceutical Analysis

Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases

(2020) Dalifer D Freites Nuñez et al.   ANNALS OF THE RHEUMATIC DISEASES

Non‐steroidal anti‐inflammatory drugs, prostaglandins and COVID‐19

(2020) Calum T. Robb et al.   BRITISH JOURNAL OF PHARMACOLOGY

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

(2020) He-wei Jiang et al.   Cellular & Molecular Immunology

What is the role of supplementation with ascorbic acid, zinc, vitamin D, or N-acetylcysteine for prevention or treatment of COVID-19?

(2020) Seth R. Bauer et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

The use of IV vitamin C for patients with COVID-19: a case series

(2020) Raul Hiedra et al.   Expert Review of Anti-Infective Therapy

Rationale for the use of N -acetylcysteine in both prevention and adjuvant therapy of COVID-19

(2020) Silvio De Flora et al.   FASEB JOURNAL

N-acetylcysteine as a potential treatment for novel coronavirus disease 2019

(2020) Rangel-Méndez Jorge-Aarón et al.   Future Microbiology

Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?

(2020) Marvin Edeas et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Redox-Modulating Agents in the Treatment of Viral Infections

(2020) Paola Checconi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID‐19 patients in Michigan, United States

(2020) Z. Imam et al.   JOURNAL OF INTERNAL MEDICINE

The protein expression profile of ACE2 in human tissues

(2020) Feria Hikmet et al.   Molecular Systems Biology

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

(2020) Yanwei Li et al.   PHARMACOLOGICAL RESEARCH

Severe COVID-19: NLRP3 Inflammasome Dysregulated

(2020) Daan F. van den Berg et al.   Frontiers in Immunology

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19

(2020) Joe M. McCord et al.   Antioxidants

The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19

(2020) Francesca Silvagno et al.   Antioxidants

Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections

(2020) Frank A. D. T. G. Wagener et al.   Antioxidants

Impact of Thiol–Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin-Converting Enzyme 2 Receptor

(2020) Sanchita Hati et al.   ACS Omega

New insights into the cell- and tissue-specificity of glucocorticoid actions

(2020) Linda Quatrini et al.   Cellular & Molecular Immunology

COVID-19 is, in the end, an endothelial disease

(2020) Peter Libby et al.   EUROPEAN HEART JOURNAL

MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale

(2020) Paul E. Marik et al.   Expert Review of Anti-Infective Therapy

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

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Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19

(2020) Coraline Radermecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

(2020) Rubens Cecchini et al.   MEDICAL HYPOTHESES

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Can Activation of NRF2 Be a Strategy against COVID-19?

(2020) Antonio Cuadrado et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

(2020) David Olagnier et al.   Nature Communications

Human recombinant soluble ACE2 in severe COVID-19

(2020) Alexander Zoufaly et al.   Lancet Respiratory Medicine

Immune-Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19

(2020) M. Mrityunjaya et al.   Frontiers in Immunology

Nox2 activation in Covid-19

(2020) Francesco Violi et al.   Redox Biology

Sex Hormones and Hormone Therapy during COVID-19 Pandemic: Implications for Patients with Cancer

(2020) Carlo Cattrini et al.   Cancers

Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

(2020) Natalia de las Heras et al.   Antioxidants

Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial

(2020) Khalil Ansarin et al.   BioImpacts

SARS-CoV-2 and Other Respiratory Viruses: What Does Oxidative Stress Have to Do with It?

(2020) Iara Grigoletto Fernandes et al.   Oxidative Medicine and Cellular Longevity

SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?

(2020) Ming Yang et al.   Cell Death Discovery

Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea

(2020) Kyungmin Huh et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux

(2019) Leandro Silva da Costa et al.   Cell Death & Disease

Protective effects of ambroxol in psoriasis like skin inflammation: Exploration of possible mechanisms

(2019) Shruthi Sunkari et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of N-acetyl-cysteine and β-mercaptoethylamine

(2019) Rita Crinelli et al.   Nutrients

Platelet Oxidative Stress and its Relationship with Cardiovascular Diseases in Type 2 Diabetes Mellitus Patients

(2019) Mohammed El Haouari   CURRENT MEDICINAL CHEMISTRY

Collateral Damage: Necroptosis in the Development of Lung Injury

(2019) Hilary Faust et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells

(2019) Yang Long et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program

(2019) Emanuel Wyler et al.   Nature Communications

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca 2+ Transfer

(2018) Riccardo Filadi et al.   CURRENT BIOLOGY

Recent advances in inflammasome biology

(2018) David E Place et al.   CURRENT OPINION IN IMMUNOLOGY

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

Vitamin C for the treatment of sepsis: The scientific rationale

(2018) Paul E. Marik   PHARMACOLOGY & THERAPEUTICS

Measuring and interpreting platelet-leukocyte aggregates

(2018) Michaela Finsterbusch et al.   PLATELETS

Impaired resolution of DSS-induced colitis in mice lacking the glucocorticoid receptor in myeloid cells

(2018) Garrit K. Meers et al.   PLoS One

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

Redox Biology of Respiratory Viral Infections

(2018) Olga Khomich et al.   Viruses-Basel

Cell Death in the Lung: The Apoptosis–Necroptosis Axis

(2018) Maor Sauler et al.   Annual Review of Physiology

Dimethyl fumarate treatment in multiple sclerosis: Recent advances in clinical and immunological studies

(2018) Gwendoline Montes Diaz et al.   AUTOIMMUNITY REVIEWS

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

(2017) Yuan Yuan et al.   Nature Communications

Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?

(2016) Mark C. Chappell   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mefenamic acid in combination with ribavirin shows significant effects in reducing chikungunya virus infection in vitro and in vivo

(2016) Hussin A. Rothan et al.   ANTIVIRAL RESEARCH

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ambroxol inhalation ameliorates LPS-induced airway inflammation and mucus secretion through the extracellular signal-regulated kinase 1/2 signaling pathway

(2016) Shui-juan Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis

(2016) Alaa Badawi et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation

(2016) Eric Metzger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation

(2016) Frantzeska Frantzeskaki et al.   RESPIRATION

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation

(2016) Eric Metzger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endothelial Response to Glucocorticoids in Inflammatory Diseases

(2016) Karolina A. Zielińska et al.   Frontiers in Immunology

The Emerging Role of NETs in Venous Thrombosis and Immunothrombosis

(2016) Andrew S. Kimball et al.   Frontiers in Immunology

Platelets in the pathogenesis of acute respiratory distress syndrome

(2015) Hemang Yadav et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

The Angiotensin-Converting Enzyme 2/Angiotensin (1–7)/Mas Axis Protects Against Lung Fibroblast Migration and Lung Fibrosis by Inhibiting the NOX4-Derived ROS-Mediated RhoA/Rho Kinase Pathway

(2015) Ying Meng et al.   ANTIOXIDANTS & REDOX SIGNALING

NLRP3 inflammasome expression is driven by NF-κB in cultured hepatocytes

(2015) Sorina Georgiana Boaru et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation

(2015) Meike Dittmann et al.   CELL

The Acute Respiratory Distress Syndrome: From Mechanism to Translation

(2015) SeungHye Han et al.   JOURNAL OF IMMUNOLOGY

Diagnostic and prognostic utility of tissue factor for severe sepsis and sepsis-induced acute lung injury

(2015) Mingming Xue et al.   Journal of Translational Medicine

Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease

(2015) Ioannis Mitroulis et al.   PHARMACOLOGY & THERAPEUTICS

Colchicine—Update on mechanisms of action and therapeutic uses

(2015) Ying Ying Leung et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Oligomerized, filamentous surface presentation of RANTES/CCL5 on vascular endothelial cells

(2015) Inger Øynebråten et al.   Scientific Reports

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

Androgen Receptor CAG Repeat Polymorphism and Risk of TMPRSS2:ERG-Positive Prostate Cancer

(2014) S. Yoo et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome

(2014) Chong-Shan Shi et al.   JOURNAL OF IMMUNOLOGY

Neutrophils scan for activated platelets to initiate inflammation

(2014) Vinatha Sreeramkumar et al.   SCIENCE

Biological basis and pathological relevance of microvascular thrombosis

(2014) Susanne Pfeiler et al.   THROMBOSIS RESEARCH

The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis

(2014) J. M. Lucas et al.   Cancer Discovery

Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis

(2013) Isabel Lastres-Becker et al.   BRAIN

Adjunctive therapies and immunomodulating agents for severe influenza

(2013) David S. C. Hui et al.   Influenza and Other Respiratory Viruses

Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS

(2013) Vaibhav B. Patel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore

(2013) John M. Busillo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Vitamin C: A Novel Regulator of Neutrophil Extracellular Trap Formation

(2013) Bassem Mohammed et al.   Nutrients

Angiotensin II and Oxidative Stress in the Failing Heart

(2012) Daniela Zablocki et al.   ANTIOXIDANTS & REDOX SIGNALING

Angiotensin II-Induced Production of Mitochondrial Reactive Oxygen Species: Potential Mechanisms and Relevance for Cardiovascular Disease

(2012) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages

(2012) Yu Qiao et al.   FEBS LETTERS

Mitochondrial redox signalling at a glance

(2012) Yvonne Collins et al.   JOURNAL OF CELL SCIENCE

Monocyte tissue factor–dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

(2012) A. Phillip Owens et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus Pathogenesis

(2012) Ruth McBride et al.   Viruses-Basel

N-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary disease

(2012) Anna M. Sadowska   Therapeutic Advances in Respiratory Disease

Redox Regulation of the Influenza Hemagglutinin Maturation Process: A New Cell-Mediated Strategy for Anti-Influenza Therapy

(2011) Rossella Sgarbanti et al.   ANTIOXIDANTS & REDOX SIGNALING

N-acetyl-l-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)

(2011) Manuel Mata et al.   BIOCHEMICAL PHARMACOLOGY

NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease

(2011) A. Boutten et al.   TRENDS IN MOLECULAR MEDICINE

Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of viral control over the cellular survival pathway

(2011) U C Halder et al.   Cell Death & Disease

Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity

(2010) F. Vallelian et al.   BLOOD

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Activation of TACE-Mediated Ectodomain Shedding by p38 MAP Kinase Regulates EGF Receptor-Dependent Cell Proliferation

(2010) Pinglong Xu et al.   MOLECULAR CELL

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cytokine production by islets in health and diabetes: cellular origin, regulation and function

(2010) Marc Y. Donath et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

N-acetyl-l-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus

(2009) Janina Geiler et al.   BIOCHEMICAL PHARMACOLOGY

Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury

(2009) Anil Sapru et al.   INTENSIVE CARE MEDICINE

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Androgen receptor and androgen-dependent gene expression in lung

(2009) Laura Mikkonen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-κB pathway in human monocyte macrophages in vitro

(2009) Susan F. Dosch et al.   VIRUS RESEARCH

Oxidative Stress and Platelets

(2008) Jane E. Freedman   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Glucocorticoid-induced leucine zipper (GILZ) mediates glucocorticoid action and inhibits inflammatory cytokine-induced COX-2 expression

(2007) Nianlan Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY